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- W4213456241 abstract "Paclitaxel resistance is a challenging factor in chemotherapy resulting in poor prognosis and cancer recurrence. Signal transducer and activator of transcription factor 3 (STAT3), a key transcription factor, performs a critical role in cancer development, cell survival and chemoresistance, while its inactivation overwhelms drug resistance in numerous cancer types including lung cancer. Additionally, the fucosyltransferase 4 (FUT4) is a crucial enzyme in post-translational modification of cell-surface proteins involved in various pathological conditions such as tumor multidrug resistance (MDR). The P-glycoprotein (P-GP) is the well-known ABC transporter member that imparts drug resistance in different cancer types, most notably paclitaxel resistance in lung cancer cells. LncRNA-MALAT1 exerts a functional role in the cancer development as well as the drug resistance and is linked with STAT3 activation and activity of FUT4. Moreover, STAT3-mediated induction of P-GP is well-documented. Natural compounds of Sesquiterpene Lactone (SL) family are well-known for their anticancer properties with particular emphasis over STAT3 inhibitory capabilities. In this study, we explored the positive correlation of MALAT1 with STAT3 and FUT4 activity in paclitaxel resistant A549 (A549/T) lung cancer cells. Additionally, we investigated the anticancer activity of two well-known members of SLs, alantolactone (ALT) and Brevilin A (Brv-A), in A549/T lung cancer cells. ALT and Brv-A induced apoptosis in A549/T cells. Furthermore, these two natural SLs suppressed MALAT1 expression, STAT3 activation, and FUT4 and P-GP expression which are the hallmarks for paclitaxel resistance in A549 lung cancer cells. The inhibition of MALAT1 enhanced the competence of these SLs members significantly, which accounted for the growth inhibition as well as anti-migratory and anti-invasive effects of ALT and Brv-A. These findings suggest SLs to be the promising agents for overcoming paclitaxel resistance in A549 lung cancer cells." @default.
- W4213456241 created "2022-02-25" @default.
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- W4213456241 date "2022-02-24" @default.
- W4213456241 modified "2023-10-14" @default.
- W4213456241 title "Sesquiterpene Lactones Attenuate Paclitaxel Resistance Via Inhibiting MALAT1/STAT3/ FUT4 Axis and P-Glycoprotein Transporters in Lung Cancer Cells" @default.
- W4213456241 cites W1545911557 @default.
- W4213456241 cites W1887624773 @default.
- W4213456241 cites W1942602300 @default.
- W4213456241 cites W1946213204 @default.
- W4213456241 cites W1983011271 @default.
- W4213456241 cites W1993757260 @default.
- W4213456241 cites W1994947876 @default.
- W4213456241 cites W2005994399 @default.
- W4213456241 cites W2007015770 @default.
- W4213456241 cites W2012929068 @default.
- W4213456241 cites W2015561372 @default.
- W4213456241 cites W2035390577 @default.
- W4213456241 cites W2038693071 @default.
- W4213456241 cites W2059084991 @default.
- W4213456241 cites W2096765666 @default.
- W4213456241 cites W2104916446 @default.
- W4213456241 cites W2105598216 @default.
- W4213456241 cites W2115009923 @default.
- W4213456241 cites W2126373871 @default.
- W4213456241 cites W2126717546 @default.
- W4213456241 cites W2127307810 @default.
- W4213456241 cites W2128619556 @default.
- W4213456241 cites W2132629607 @default.
- W4213456241 cites W2138193535 @default.
- W4213456241 cites W2142868310 @default.
- W4213456241 cites W2149170646 @default.
- W4213456241 cites W2154915448 @default.
- W4213456241 cites W2158217645 @default.
- W4213456241 cites W2163802438 @default.
- W4213456241 cites W2167122624 @default.
- W4213456241 cites W2262355153 @default.
- W4213456241 cites W2294054163 @default.
- W4213456241 cites W2339703473 @default.
- W4213456241 cites W2342038157 @default.
- W4213456241 cites W2347003476 @default.
- W4213456241 cites W2412403360 @default.
- W4213456241 cites W241310830 @default.
- W4213456241 cites W2463639643 @default.
- W4213456241 cites W2511229996 @default.
- W4213456241 cites W2534390269 @default.
- W4213456241 cites W2570618306 @default.
- W4213456241 cites W2612443381 @default.
- W4213456241 cites W2737560814 @default.
- W4213456241 cites W2745118608 @default.
- W4213456241 cites W2766117110 @default.
- W4213456241 cites W2770249785 @default.
- W4213456241 cites W2780193133 @default.
- W4213456241 cites W2783056471 @default.
- W4213456241 cites W2789246863 @default.
- W4213456241 cites W2805913079 @default.
- W4213456241 cites W2806118255 @default.
- W4213456241 cites W2808862148 @default.
- W4213456241 cites W2809447839 @default.
- W4213456241 cites W2887172059 @default.
- W4213456241 cites W2900593311 @default.
- W4213456241 cites W2900767822 @default.
- W4213456241 cites W2917889191 @default.
- W4213456241 cites W2937019863 @default.
- W4213456241 cites W2967666742 @default.
- W4213456241 cites W2991057166 @default.
- W4213456241 cites W2999308880 @default.
- W4213456241 cites W3010696851 @default.
- W4213456241 cites W3012294701 @default.
- W4213456241 cites W3012774707 @default.
- W4213456241 cites W3012955228 @default.
- W4213456241 cites W3015412873 @default.
- W4213456241 cites W3020914566 @default.
- W4213456241 cites W3042358368 @default.
- W4213456241 cites W3088389433 @default.
- W4213456241 cites W3096514992 @default.
- W4213456241 cites W3154854350 @default.
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- W4213456241 doi "https://doi.org/10.3389/fphar.2022.795613" @default.
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- W4213456241 hasPublicationYear "2022" @default.
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