Matches in SemOpenAlex for { <https://semopenalex.org/work/W4214484815> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W4214484815 abstract "Abstract It remains an open question when and why psychiatric and other disease evolved in human evolutionary history. We harness large genome-wide association studies and recent studies that have identified human-gained epigenetic marks, selective sweeps, archaic introgression, and accelerated evolution to help tackle this question by assessing the enrichment of heritability in these sequence elements for 41 complex traits. We find that human-gained epigenetic elements in the fetal brain harbor variants affecting skeletal, dermatological, and respiratory traits early and psychiatric traits later in development, that genomic sequences under selection since our divergence with Neanderthals are enriched in heritability for autism, and that regions depleted in ancestry from other hominids contribute more to heritability for psychiatric than other traits. Psychiatric disease may be a concomitant outcome of the evolutionary processes that made us uniquely human. One-Sentence Summary Variants that cause autism and other psychiatric disease today co-locate with sequence elements that have been important during human evolution." @default.
- W4214484815 created "2022-03-02" @default.
- W4214484815 creator A5077936005 @default.
- W4214484815 date "2022-03-01" @default.
- W4214484815 modified "2023-10-03" @default.
- W4214484815 title "Investigating relative contributions to psychiatric disease architecture from sequence elements originating across multiple evolutionary time-scales" @default.
- W4214484815 cites W1681270005 @default.
- W4214484815 cites W169361512 @default.
- W4214484815 cites W1844405070 @default.
- W4214484815 cites W1970304238 @default.
- W4214484815 cites W1977489472 @default.
- W4214484815 cites W1986803878 @default.
- W4214484815 cites W2001610569 @default.
- W4214484815 cites W2053433605 @default.
- W4214484815 cites W2054254341 @default.
- W4214484815 cites W2073357777 @default.
- W4214484815 cites W2076154138 @default.
- W4214484815 cites W2104549677 @default.
- W4214484815 cites W2107916366 @default.
- W4214484815 cites W2133663604 @default.
- W4214484815 cites W2156003764 @default.
- W4214484815 cites W2164996823 @default.
- W4214484815 cites W2176749178 @default.
- W4214484815 cites W2256694280 @default.
- W4214484815 cites W2279984879 @default.
- W4214484815 cites W2337955410 @default.
- W4214484815 cites W2522953732 @default.
- W4214484815 cites W2586586494 @default.
- W4214484815 cites W2739359488 @default.
- W4214484815 cites W2750693584 @default.
- W4214484815 cites W2789000322 @default.
- W4214484815 cites W2794087945 @default.
- W4214484815 cites W2951099441 @default.
- W4214484815 cites W2952656771 @default.
- W4214484815 cites W2952882474 @default.
- W4214484815 cites W2969996045 @default.
- W4214484815 cites W2971473882 @default.
- W4214484815 cites W3110863572 @default.
- W4214484815 cites W3118572197 @default.
- W4214484815 cites W3120392574 @default.
- W4214484815 doi "https://doi.org/10.1101/2022.02.28.482389" @default.
- W4214484815 hasPublicationYear "2022" @default.
- W4214484815 type Work @default.
- W4214484815 citedByCount "3" @default.
- W4214484815 countsByYear W42144848152022 @default.
- W4214484815 countsByYear W42144848152023 @default.
- W4214484815 crossrefType "posted-content" @default.
- W4214484815 hasAuthorship W4214484815A5077936005 @default.
- W4214484815 hasBestOaLocation W42144848151 @default.
- W4214484815 hasConcept C104317684 @default.
- W4214484815 hasConcept C118552586 @default.
- W4214484815 hasConcept C142724271 @default.
- W4214484815 hasConcept C15744967 @default.
- W4214484815 hasConcept C161890455 @default.
- W4214484815 hasConcept C185554395 @default.
- W4214484815 hasConcept C205778803 @default.
- W4214484815 hasConcept C2779134260 @default.
- W4214484815 hasConcept C41091548 @default.
- W4214484815 hasConcept C54355233 @default.
- W4214484815 hasConcept C71924100 @default.
- W4214484815 hasConcept C78458016 @default.
- W4214484815 hasConcept C8182607 @default.
- W4214484815 hasConcept C81941488 @default.
- W4214484815 hasConcept C86803240 @default.
- W4214484815 hasConcept C9287583 @default.
- W4214484815 hasConceptScore W4214484815C104317684 @default.
- W4214484815 hasConceptScore W4214484815C118552586 @default.
- W4214484815 hasConceptScore W4214484815C142724271 @default.
- W4214484815 hasConceptScore W4214484815C15744967 @default.
- W4214484815 hasConceptScore W4214484815C161890455 @default.
- W4214484815 hasConceptScore W4214484815C185554395 @default.
- W4214484815 hasConceptScore W4214484815C205778803 @default.
- W4214484815 hasConceptScore W4214484815C2779134260 @default.
- W4214484815 hasConceptScore W4214484815C41091548 @default.
- W4214484815 hasConceptScore W4214484815C54355233 @default.
- W4214484815 hasConceptScore W4214484815C71924100 @default.
- W4214484815 hasConceptScore W4214484815C78458016 @default.
- W4214484815 hasConceptScore W4214484815C8182607 @default.
- W4214484815 hasConceptScore W4214484815C81941488 @default.
- W4214484815 hasConceptScore W4214484815C86803240 @default.
- W4214484815 hasConceptScore W4214484815C9287583 @default.
- W4214484815 hasLocation W42144848151 @default.
- W4214484815 hasOpenAccess W4214484815 @default.
- W4214484815 hasPrimaryLocation W42144848151 @default.
- W4214484815 hasRelatedWork W1911362654 @default.
- W4214484815 hasRelatedWork W2033021653 @default.
- W4214484815 hasRelatedWork W2112660632 @default.
- W4214484815 hasRelatedWork W2864687363 @default.
- W4214484815 hasRelatedWork W3118933652 @default.
- W4214484815 hasRelatedWork W3133151252 @default.
- W4214484815 hasRelatedWork W3154562748 @default.
- W4214484815 hasRelatedWork W4229066186 @default.
- W4214484815 hasRelatedWork W4247931753 @default.
- W4214484815 hasRelatedWork W4250154048 @default.
- W4214484815 isParatext "false" @default.
- W4214484815 isRetracted "false" @default.
- W4214484815 workType "article" @default.