FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4214492028> ?p ?o ?g. }

• W4214492028 endingPage "3502" @default.
• W4214492028 startingPage "3492" @default.
• W4214492028 abstract "Limited information is available on the relevant prognostic variables after surgery for patients with pancreatic ductal adenocarcinoma (PDAC) subjected to neoadjuvant chemotherapy (NACT). NACT is known to induce a spectrum of histological changes in PDAC. Different grading regression systems are currently available; unfortunately, they lack precision and accuracy. We aimed to identify a new quantitative prognostic index based on tumor morphology.The study population was composed of 69 patients with resectable or borderline resectable PDAC treated with preoperative NACT (neoadjuvant group) and 36 patients submitted to upfront surgery (upfront-surgery group). A comprehensive histological assessment on hematoxylin and eosin (H&E) stained sections evaluated 20 morphological parameters. The association between patient survival and morphological variables was evaluated to generate a prognostic index.The distribution of morphological parameters evaluated was significantly different between upfront-surgery and neoadjuvant groups, demonstrating the effect of NACT on tumor morphology. On multivariate analysis for patients that received NACT, the predictors of shorter overall survival (OS) and disease-free survival (DFS) were perineural invasion and lymph node ratio. Conversely, high stroma to neoplasia ratio predicted longer OS and DFS. These variables were combined to generate a semiquantitative prognostic index based on both OS and DFS, which significantly distinguished patients with poor outcomes from those with a good outcome. Bootstrap analysis confirmed the reproducibility of the model.The pathologic prognostic index proposed is mostly quantitative in nature, easy to use, and may represent a reliable tumor regression grading system to predict patient outcomes after NACT followed by surgery for PDAC." @default.
• W4214492028 created "2022-03-02" @default.
• W4214492028 creator A5000713680 @default.
• W4214492028 creator A5033134171 @default.
• W4214492028 creator A5038760660 @default.
• W4214492028 creator A5046880314 @default.
• W4214492028 creator A5047380313 @default.
• W4214492028 creator A5052627162 @default.
• W4214492028 creator A5057380925 @default.
• W4214492028 creator A5070770739 @default.
• W4214492028 creator A5076163246 @default.
• W4214492028 creator A5082791089 @default.
• W4214492028 creator A5085112023 @default.
• W4214492028 date "2022-03-01" @default.
• W4214492028 modified "2023-09-26" @default.
• W4214492028 title "Proposal for a New Pathologic Prognostic Index After Neoadjuvant Chemotherapy in Pancreatic Ductal Adenocarcinoma (PINC)" @default.
• W4214492028 cites W1972465871 @default.
• W4214492028 cites W1977468182 @default.
• W4214492028 cites W1998805086 @default.
• W4214492028 cites W2042280230 @default.
• W4214492028 cites W2068504442 @default.
• W4214492028 cites W2077003423 @default.
• W4214492028 cites W2089348717 @default.
• W4214492028 cites W2107236131 @default.
• W4214492028 cites W2110401386 @default.
• W4214492028 cites W2152387274 @default.
• W4214492028 cites W2230446461 @default.
• W4214492028 cites W2297864834 @default.
• W4214492028 cites W2408827639 @default.
• W4214492028 cites W2431396139 @default.
• W4214492028 cites W2465630774 @default.
• W4214492028 cites W2519690159 @default.
• W4214492028 cites W2549218823 @default.
• W4214492028 cites W2597657200 @default.
• W4214492028 cites W2743061229 @default.
• W4214492028 cites W2796434454 @default.
• W4214492028 cites W2888094806 @default.
• W4214492028 cites W2889646458 @default.
• W4214492028 cites W2894271155 @default.
• W4214492028 cites W2908229190 @default.
• W4214492028 cites W2946893672 @default.
• W4214492028 cites W2948066892 @default.
• W4214492028 cites W3092103339 @default.
• W4214492028 cites W3094306249 @default.
• W4214492028 cites W3128594599 @default.
• W4214492028 cites W3138238630 @default.
• W4214492028 cites W4249522930 @default.
• W4214492028 doi "https://doi.org/10.1245/s10434-022-11413-7" @default.
• W4214492028 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35230580" @default.
• W4214492028 hasPublicationYear "2022" @default.
• W4214492028 type Work @default.
• W4214492028 citedByCount "4" @default.
• W4214492028 countsByYear W42144920282022 @default.
• W4214492028 countsByYear W42144920282023 @default.
• W4214492028 crossrefType "journal-article" @default.
• W4214492028 hasAuthorship W4214492028A5000713680 @default.
• W4214492028 hasAuthorship W4214492028A5033134171 @default.
• W4214492028 hasAuthorship W4214492028A5038760660 @default.
• W4214492028 hasAuthorship W4214492028A5046880314 @default.
• W4214492028 hasAuthorship W4214492028A5047380313 @default.
• W4214492028 hasAuthorship W4214492028A5052627162 @default.
• W4214492028 hasAuthorship W4214492028A5057380925 @default.
• W4214492028 hasAuthorship W4214492028A5070770739 @default.
• W4214492028 hasAuthorship W4214492028A5076163246 @default.
• W4214492028 hasAuthorship W4214492028A5082791089 @default.
• W4214492028 hasAuthorship W4214492028A5085112023 @default.
• W4214492028 hasBestOaLocation W42144920281 @default.
• W4214492028 hasConcept C121608353 @default.
• W4214492028 hasConcept C126322002 @default.
• W4214492028 hasConcept C126838900 @default.
• W4214492028 hasConcept C127413603 @default.
• W4214492028 hasConcept C142724271 @default.
• W4214492028 hasConcept C143998085 @default.
• W4214492028 hasConcept C147176958 @default.
• W4214492028 hasConcept C2777154038 @default.
• W4214492028 hasConcept C2777286243 @default.
• W4214492028 hasConcept C2778292576 @default.
• W4214492028 hasConcept C2780140570 @default.
• W4214492028 hasConcept C2780210213 @default.
• W4214492028 hasConcept C2780849966 @default.
• W4214492028 hasConcept C2781182431 @default.
• W4214492028 hasConcept C2908647359 @default.
• W4214492028 hasConcept C2992026798 @default.
• W4214492028 hasConcept C38180746 @default.
• W4214492028 hasConcept C530470458 @default.
• W4214492028 hasConcept C71924100 @default.
• W4214492028 hasConcept C99454951 @default.
• W4214492028 hasConceptScore W4214492028C121608353 @default.
• W4214492028 hasConceptScore W4214492028C126322002 @default.
• W4214492028 hasConceptScore W4214492028C126838900 @default.
• W4214492028 hasConceptScore W4214492028C127413603 @default.
• W4214492028 hasConceptScore W4214492028C142724271 @default.
• W4214492028 hasConceptScore W4214492028C143998085 @default.
• W4214492028 hasConceptScore W4214492028C147176958 @default.
• W4214492028 hasConceptScore W4214492028C2777154038 @default.
• W4214492028 hasConceptScore W4214492028C2777286243 @default.
• W4214492028 hasConceptScore W4214492028C2778292576 @default.
• W4214492028 hasConceptScore W4214492028C2780140570 @default.

• next