FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4214507887> ?p ?o ?g. }

• W4214507887 endingPage "1477" @default.
• W4214507887 startingPage "1457" @default.
• W4214507887 abstract "Alzheimer’s disease (AD) is the most common form of dementia. Despite enormous efforts around the world, there remains no effective cure for AD. This study was performed to investigate the effects of long-term exercise pretreatment on the typical pathology of AD in a novel transgenic AD rat model. Male 2-month-old animals were divided into the following groups: wild-type (WT) rats, AD rats, and AD rats with treadmill exercise pretreatment (AD-Exe). After exercise pretreatment, the Barnes maze task, passive avoidance task, and cued fear conditioning test were performed to test learning and memory function. The elevated plus maze, open field test, sucrose preference test, and forced swim test were conducted to measure anxious-depressive–like behavior. Immunofluorescence staining, Golgi staining, transmission electron microscopy, Western blot analysis, F-Jade C staining, TUNEL staining, and related assay kits were conducted to measure Aβ plaques, tau hyperphosphorylation, neuronal damage, neuronal degeneration, dendritic spine density, synapses, synaptic vesicles, mitochondrial morphology, mitochondrial dynamic, oxidative stress, and neuroinflammation. Behavioral tests revealed that long-term exercise pretreatment significantly alleviated learning and memory dysfunction and anxious-depressive–like behaviors in AD animals. In addition, exercise pretreatment attenuated amyloid-β deposition and tau hyperphosphorylation and preserved spine density, synapses, and presynaptic vesicles. Exercise also inhibited neuronal damage, neuronal apoptosis, and neuronal degeneration. Additional studies revealed the imbalance of mitochondrial dynamics was significantly inhibited by exercise pretreatment accompanied by a remarkable suppression of oxidative stress and neuroinflammation. Our findings suggest that long-term exercise pretreatment alleviated behavioral deficits and typical pathologies of the AD rat model, supporting long-term exercise pretreatment as a potential approach to delay the progression of AD." @default.
• W4214507887 created "2022-03-02" @default.
• W4214507887 creator A5007165393 @default.
• W4214507887 creator A5012235549 @default.
• W4214507887 creator A5014569865 @default.
• W4214507887 creator A5034887182 @default.
• W4214507887 creator A5040130754 @default.
• W4214507887 creator A5045022912 @default.
• W4214507887 creator A5059729786 @default.
• W4214507887 creator A5077875358 @default.
• W4214507887 creator A5089194546 @default.
• W4214507887 date "2022-02-28" @default.
• W4214507887 modified "2023-10-18" @default.
• W4214507887 title "Long-term exercise pre-training attenuates Alzheimer’s disease–related pathology in a transgenic rat model of Alzheimer’s disease" @default.
• W4214507887 cites W147870220 @default.
• W4214507887 cites W1516122098 @default.
• W4214507887 cites W1566857126 @default.
• W4214507887 cites W1618134065 @default.
• W4214507887 cites W1940759671 @default.
• W4214507887 cites W1964160578 @default.
• W4214507887 cites W1968362444 @default.
• W4214507887 cites W1976778744 @default.
• W4214507887 cites W1990393276 @default.
• W4214507887 cites W1993249718 @default.
• W4214507887 cites W1998411467 @default.
• W4214507887 cites W2025563134 @default.
• W4214507887 cites W2040268226 @default.
• W4214507887 cites W2042487795 @default.
• W4214507887 cites W2044987522 @default.
• W4214507887 cites W2087243986 @default.
• W4214507887 cites W2089135389 @default.
• W4214507887 cites W2099751992 @default.
• W4214507887 cites W2118867129 @default.
• W4214507887 cites W2141789735 @default.
• W4214507887 cites W2145260966 @default.
• W4214507887 cites W2156326104 @default.
• W4214507887 cites W2166578434 @default.
• W4214507887 cites W2500200225 @default.
• W4214507887 cites W2510053021 @default.
• W4214507887 cites W2524512063 @default.
• W4214507887 cites W2563078526 @default.
• W4214507887 cites W2585086069 @default.
• W4214507887 cites W2727735765 @default.
• W4214507887 cites W2765463414 @default.
• W4214507887 cites W2771880634 @default.
• W4214507887 cites W2789018622 @default.
• W4214507887 cites W2790798430 @default.
• W4214507887 cites W2790992274 @default.
• W4214507887 cites W2791214008 @default.
• W4214507887 cites W2806300791 @default.
• W4214507887 cites W2884398671 @default.
• W4214507887 cites W2889787710 @default.
• W4214507887 cites W2889808182 @default.
• W4214507887 cites W2899289666 @default.
• W4214507887 cites W2904244708 @default.
• W4214507887 cites W2911115742 @default.
• W4214507887 cites W2913440408 @default.
• W4214507887 cites W2918016998 @default.
• W4214507887 cites W2921833512 @default.
• W4214507887 cites W2941749695 @default.
• W4214507887 cites W2967881301 @default.
• W4214507887 cites W2972382635 @default.
• W4214507887 cites W2973473061 @default.
• W4214507887 cites W2984986547 @default.
• W4214507887 cites W2997708235 @default.
• W4214507887 cites W3004354477 @default.
• W4214507887 cites W3005128382 @default.
• W4214507887 cites W3008202901 @default.
• W4214507887 cites W3016073931 @default.
• W4214507887 cites W3029234273 @default.
• W4214507887 cites W3032085306 @default.
• W4214507887 cites W3112997587 @default.
• W4214507887 cites W3123303506 @default.
• W4214507887 cites W622376569 @default.
• W4214507887 doi "https://doi.org/10.1007/s11357-022-00534-2" @default.
• W4214507887 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35229257" @default.
• W4214507887 hasPublicationYear "2022" @default.
• W4214507887 type Work @default.
• W4214507887 citedByCount "17" @default.
• W4214507887 countsByYear W42145078872022 @default.
• W4214507887 countsByYear W42145078872023 @default.
• W4214507887 crossrefType "journal-article" @default.
• W4214507887 hasAuthorship W4214507887A5007165393 @default.
• W4214507887 hasAuthorship W4214507887A5012235549 @default.
• W4214507887 hasAuthorship W4214507887A5014569865 @default.
• W4214507887 hasAuthorship W4214507887A5034887182 @default.
• W4214507887 hasAuthorship W4214507887A5040130754 @default.
• W4214507887 hasAuthorship W4214507887A5045022912 @default.
• W4214507887 hasAuthorship W4214507887A5059729786 @default.
• W4214507887 hasAuthorship W4214507887A5077875358 @default.
• W4214507887 hasAuthorship W4214507887A5089194546 @default.
• W4214507887 hasBestOaLocation W42145078872 @default.
• W4214507887 hasConcept C126322002 @default.
• W4214507887 hasConcept C134018914 @default.
• W4214507887 hasConcept C136569192 @default.
• W4214507887 hasConcept C142724271 @default.
• W4214507887 hasConcept C148762608 @default.
• W4214507887 hasConcept C15744967 @default.

• next