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• W4214509917 abstract "Microplitis bicoloratus bracovirus (MbBV) induces apoptosis in hemocytes of the host (Spodoptera litura) via the cyclophilin A (CypA)-mediated signaling pathway. However, the mechanisms underlying CypA-mediated signaling during apoptosis remain largely unknown. Therefore, in this study, we investigated how CypA and apoptosis-inducing factor (AIF) interact during MbBV-mediated apoptosis. Our findings showed that MbBV induces apoptosis through the CypA-AIF axis of insect immune suppression. In MbBV-infected Spli221 cells, both the expression of the cypa gene and the release of AIF from the mitochondria increased the number of apoptotic cells. CypA and AIF underwent concurrent cytoplasm-nuclear translocation. Conversely, blocking of AIF release from mitochondria not only inhibited the CypA-AIF interaction but also inhibited the cytoplasmic-nuclear translocation of AIF and CypA. Importantly, the survival of the apoptotic phenotype was significantly rescued in MbBV-infected Spli221 cells. In addition, we found that the cyclosporine A-mediated inhibition of CypA did not prevent the formation of the CypA and AIF complex; rather, this only suppressed genomic DNA fragmentation. In vitro experiments revealed direct molecular interactions between recombinant CypA and AIF. Taken together, our results demonstrate that the CypA-AIF interaction plays an important role in MbBV-induced innate immune suppression. This study will help to clarify aspects of insect immunological mechanisms and will be relevant to biological pest control." @default.
• W4214509917 created "2022-03-02" @default.
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• W4214509917 date "2022-02-25" @default.
• W4214509917 modified "2023-10-17" @default.
• W4214509917 title "<i>Microplitis bicoloratus</i> bracovirus regulates cyclophilin A‐apoptosis‐inducing factor interaction to induce cell apoptosis in the insect immunosuppressive process" @default.
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• W4214509917 doi "https://doi.org/10.1002/arch.21877" @default.
• W4214509917 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35218062" @default.
• W4214509917 hasPublicationYear "2022" @default.
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