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- W4214514103 abstract "Abstract Modern humans exhibit phenotypic traits that are shared across independent domestication events, suggesting the human self-domestication hypothesis. Epigenetic changes may facilitate early self-domestication in humans, since they can be the first layer of response to a novel environment. Here, we argue that fish provide model systems to study epigenetic drivers in human self-domestication. To do this, we compare genes that carry epigenetic changes in early domesticates of European sea bass with 1) anatomically modern humans and 2) neurodevelopmental cognitive disorders with abnormal self-domestication traits, i.e., schizophrenia, Williams syndrome and autism spectrum disorders. We found that genes with epigenetic changes in fish and in modern vs ancient humans were shared and were involved in processes like limb morphogenesis and phenotypes like abnormal snout morphology and hypopigmentation. Moreover, early domestication in fish and neurodevelopmental cognitive impairment in humans affected paralogue genes involved in processes such as neural crest differentiation and ectoderm differentiation. We conclude that parallel epigenetic changes may occur at the initial steps of domestication in absence of deliberate selection in phylogenetically distant vertebrates. These findings pave the way for future studies using fish as models to investigate epigenetic changes as drivers of human-self domestication and as triggers of cognitive disorders." @default.
- W4214514103 created "2022-03-02" @default.
- W4214514103 creator A5005189798 @default.
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- W4214514103 date "2022-02-28" @default.
- W4214514103 modified "2023-10-03" @default.
- W4214514103 title "Fish as model systems to study epigenetic drivers in human self-domestication and neurodevelopmental cognitive disorders" @default.
- W4214514103 cites W1436366957 @default.
- W4214514103 cites W1560020441 @default.
- W4214514103 cites W1848963797 @default.
- W4214514103 cites W1965780520 @default.
- W4214514103 cites W1966481901 @default.
- W4214514103 cites W1969353942 @default.
- W4214514103 cites W1974621279 @default.
- W4214514103 cites W1978265777 @default.
- W4214514103 cites W1981239255 @default.
- W4214514103 cites W1981454034 @default.
- W4214514103 cites W1998984510 @default.
- W4214514103 cites W2005943678 @default.
- W4214514103 cites W2015788844 @default.
- W4214514103 cites W2029409259 @default.
- W4214514103 cites W2063260002 @default.
- W4214514103 cites W2063913677 @default.
- W4214514103 cites W2069681519 @default.
- W4214514103 cites W2070050178 @default.
- W4214514103 cites W2094740113 @default.
- W4214514103 cites W2108885487 @default.
- W4214514103 cites W2119126951 @default.
- W4214514103 cites W2119978637 @default.
- W4214514103 cites W2129100031 @default.
- W4214514103 cites W2131870855 @default.
- W4214514103 cites W2132261072 @default.
- W4214514103 cites W2137719562 @default.
- W4214514103 cites W2162082393 @default.
- W4214514103 cites W2165155571 @default.
- W4214514103 cites W2263792923 @default.
- W4214514103 cites W2276437132 @default.
- W4214514103 cites W2306540176 @default.
- W4214514103 cites W2311093911 @default.
- W4214514103 cites W2323853575 @default.
- W4214514103 cites W2345356016 @default.
- W4214514103 cites W2397412877 @default.
- W4214514103 cites W2417477986 @default.
- W4214514103 cites W2531505017 @default.
- W4214514103 cites W2585464000 @default.
- W4214514103 cites W2587774385 @default.
- W4214514103 cites W2602459412 @default.
- W4214514103 cites W2611538397 @default.
- W4214514103 cites W2746542734 @default.
- W4214514103 cites W2757758004 @default.
- W4214514103 cites W2765578131 @default.
- W4214514103 cites W2803356437 @default.
- W4214514103 cites W2803750243 @default.
- W4214514103 cites W2806382960 @default.
- W4214514103 cites W2888972763 @default.
- W4214514103 cites W2893251498 @default.
- W4214514103 cites W2894989282 @default.
- W4214514103 cites W2916147005 @default.
- W4214514103 cites W2935111667 @default.
- W4214514103 cites W2952558632 @default.
- W4214514103 cites W2952836451 @default.
- W4214514103 cites W2952879013 @default.
- W4214514103 cites W2956251012 @default.
- W4214514103 cites W2975934912 @default.
- W4214514103 cites W2984778902 @default.
- W4214514103 cites W2993685839 @default.
- W4214514103 cites W3004091824 @default.
- W4214514103 cites W3005559939 @default.
- W4214514103 cites W3009791849 @default.
- W4214514103 cites W3015047534 @default.
- W4214514103 cites W3015140931 @default.
- W4214514103 cites W3017265939 @default.
- W4214514103 cites W3017308777 @default.
- W4214514103 cites W3029432838 @default.
- W4214514103 cites W3044017704 @default.
- W4214514103 cites W3081982717 @default.
- W4214514103 cites W3082269943 @default.
- W4214514103 cites W3087223592 @default.
- W4214514103 cites W3102961683 @default.
- W4214514103 cites W3110196022 @default.
- W4214514103 cites W3116614405 @default.
- W4214514103 cites W3118572197 @default.
- W4214514103 cites W3123319022 @default.
- W4214514103 cites W3128587369 @default.
- W4214514103 cites W3135237636 @default.
- W4214514103 cites W3135280042 @default.
- W4214514103 cites W3137920644 @default.
- W4214514103 cites W3145969289 @default.
- W4214514103 cites W3148216521 @default.
- W4214514103 cites W3165248043 @default.
- W4214514103 cites W3174371718 @default.
- W4214514103 cites W3178862625 @default.
- W4214514103 cites W3185319771 @default.
- W4214514103 cites W3198450109 @default.
- W4214514103 cites W3201771779 @default.
- W4214514103 cites W3205025027 @default.
- W4214514103 cites W3208007559 @default.
- W4214514103 cites W3213391974 @default.