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- W4214515580 endingPage "159139" @default.
- W4214515580 startingPage "159139" @default.
- W4214515580 abstract "Pulmonary surfactant is a mixture of lipids and proteins, consisting of 90% phospholipid, and 10% protein by weight, found predominantly in pulmonary alveoli of vertebrate lungs. Two minor components of pulmonary surfactant phospholipids, phosphatidylglycerol (PG) and phosphatidylinositol (PI), are present within the alveoli at very high concentrations, and exert anti-inflammatory effects by regulating multiple Toll like receptors (TLR2/1, TLR4, and TLR2/6) by antagonizing cognate ligand-dependent activation. POPG also attenuates LPS-induced lung injury in vivo. In addition, these lipids bind directly to RSV and influenza A viruses (IAVs) and block interaction between host cells and virions, and thereby prevent viral replication in vitro. POPG and PI also inhibit RSV and IAV infection in vivo, in mice and ferrets. The lipids markedly inhibit SARS-CoV-2 infection in vitro. These findings suggest that both POPG and PI have strong potential to be applied as both prophylaxis and post-infection treatments for problematic respiratory viral infections." @default.
- W4214515580 created "2022-03-02" @default.
- W4214515580 creator A5018027361 @default.
- W4214515580 creator A5044700206 @default.
- W4214515580 date "2022-06-01" @default.
- W4214515580 modified "2023-10-01" @default.
- W4214515580 title "Anti-inflammatory and anti-viral actions of anionic pulmonary surfactant phospholipids" @default.
- W4214515580 cites W1492593302 @default.
- W4214515580 cites W1499978168 @default.
- W4214515580 cites W1526266927 @default.
- W4214515580 cites W1545754268 @default.
- W4214515580 cites W1911996414 @default.
- W4214515580 cites W1930598094 @default.
- W4214515580 cites W1966610693 @default.
- W4214515580 cites W1978032578 @default.
- W4214515580 cites W1989501142 @default.
- W4214515580 cites W1993750390 @default.
- W4214515580 cites W1994942139 @default.
- W4214515580 cites W1998100955 @default.
- W4214515580 cites W2004773897 @default.
- W4214515580 cites W2008308371 @default.
- W4214515580 cites W2008670641 @default.
- W4214515580 cites W2009453329 @default.
- W4214515580 cites W2010890442 @default.
- W4214515580 cites W2013145676 @default.
- W4214515580 cites W2017218161 @default.
- W4214515580 cites W2025648442 @default.
- W4214515580 cites W2034705390 @default.
- W4214515580 cites W2037894162 @default.
- W4214515580 cites W2040739057 @default.
- W4214515580 cites W2047473309 @default.
- W4214515580 cites W2052739225 @default.
- W4214515580 cites W2060945789 @default.
- W4214515580 cites W2063793648 @default.
- W4214515580 cites W2068854215 @default.
- W4214515580 cites W2069157544 @default.
- W4214515580 cites W2071229169 @default.
- W4214515580 cites W2072398160 @default.
- W4214515580 cites W2080967898 @default.
- W4214515580 cites W2084584261 @default.
- W4214515580 cites W2086271810 @default.
- W4214515580 cites W2093440835 @default.
- W4214515580 cites W2094503159 @default.
- W4214515580 cites W2095169941 @default.
- W4214515580 cites W2097120859 @default.
- W4214515580 cites W2104397822 @default.
- W4214515580 cites W2104927376 @default.
- W4214515580 cites W2111011531 @default.
- W4214515580 cites W2119394949 @default.
- W4214515580 cites W2130734541 @default.
- W4214515580 cites W2130936338 @default.
- W4214515580 cites W2131135326 @default.
- W4214515580 cites W2133935205 @default.
- W4214515580 cites W2136490336 @default.
- W4214515580 cites W2137264828 @default.
- W4214515580 cites W2142973230 @default.
- W4214515580 cites W2143127434 @default.
- W4214515580 cites W2143188326 @default.
- W4214515580 cites W2144110806 @default.
- W4214515580 cites W2147414431 @default.
- W4214515580 cites W2148134519 @default.
- W4214515580 cites W2150367730 @default.
- W4214515580 cites W2151574600 @default.
- W4214515580 cites W2156207672 @default.
- W4214515580 cites W2156613610 @default.
- W4214515580 cites W2157177671 @default.
- W4214515580 cites W2164104779 @default.
- W4214515580 cites W2165893661 @default.
- W4214515580 cites W2166661291 @default.
- W4214515580 cites W2170152481 @default.
- W4214515580 cites W2170431469 @default.
- W4214515580 cites W2258703222 @default.
- W4214515580 cites W2312463092 @default.
- W4214515580 cites W2322441340 @default.
- W4214515580 cites W2336892430 @default.
- W4214515580 cites W2394980164 @default.
- W4214515580 cites W2418647617 @default.
- W4214515580 cites W2465592042 @default.
- W4214515580 cites W2558274900 @default.
- W4214515580 cites W2562335987 @default.
- W4214515580 cites W2620241325 @default.
- W4214515580 cites W2792748704 @default.
- W4214515580 cites W2806041611 @default.
- W4214515580 cites W2892275685 @default.
- W4214515580 cites W2894576954 @default.
- W4214515580 cites W2911963184 @default.
- W4214515580 cites W2997386740 @default.
- W4214515580 cites W3009584253 @default.
- W4214515580 cites W3010514783 @default.
- W4214515580 cites W3026109743 @default.
- W4214515580 cites W3046024889 @default.
- W4214515580 cites W3080149483 @default.
- W4214515580 cites W3092455678 @default.
- W4214515580 cites W3111255098 @default.
- W4214515580 cites W3111431752 @default.
- W4214515580 cites W3112902030 @default.
- W4214515580 cites W3124901567 @default.
- W4214515580 cites W3162962542 @default.