Matches in SemOpenAlex for { <https://semopenalex.org/work/W4214518311> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W4214518311 abstract "The need for reliable, sensitive (developmental) neurotoxicity testing of chemicals has steadily increased. Given the limited capacities for routine testing according to accepted regulatory guidelines, there is potential risk to human health and the environment. Most toxicity studies are based on mammalian test systems, which have been questioned for low sensitivity, limited relevance for humans, and animal welfare considerations. This increased the need for alternative models, one of which is the zebrafish (Danio rerio) embryo. This study assessed selected neonicotinoids at sub-lethal concentrations for their effects on embryonic development and behavior. The fish embryo acute toxicity test (OECD TG 236) determined the lowest observable effective concentrations, which were used as the highest test concentrations in subsequent behavioral assays. In the FET test, no severe compound-induced sublethal effects were seen at < 100 µM. In the coiling assay, exposure to ≥ 1.25 µM nicotine (positive control) affected both the burst duration and burst count per minute, whereas ≥ 50 µM thiacloprid affected the mean burst duration. Exposure to ≥ 50 µM acetamiprid and imidacloprid induced significant alterations in both mean burst duration and burst count per minute. In the swimming assay, 100 µM acetamiprid induced alterations in the frequency and extent of movements, whilst nicotine exposure only induced non-significant changes. All behavioral changes could be correlated to findings in mammalian studies. Given the quest for alternative test methods of (developmental) neurotoxicity, zebrafish embryo behavior testing could be integrated into a future tiered testing scheme." @default.
- W4214518311 created "2022-03-02" @default.
- W4214518311 creator A5036081621 @default.
- W4214518311 creator A5042450452 @default.
- W4214518311 creator A5050757664 @default.
- W4214518311 creator A5052054400 @default.
- W4214518311 creator A5060184761 @default.
- W4214518311 creator A5061191979 @default.
- W4214518311 creator A5070794803 @default.
- W4214518311 creator A5074620462 @default.
- W4214518311 creator A5082731232 @default.
- W4214518311 date "2022-01-01" @default.
- W4214518311 modified "2023-10-05" @default.
- W4214518311 title "Zebrafish embryo neonicotinoid developmental neurotoxicity in the FET test and behavioral assays" @default.
- W4214518311 doi "https://doi.org/10.14573/altex.2111021" @default.
- W4214518311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35229877" @default.
- W4214518311 hasPublicationYear "2022" @default.
- W4214518311 type Work @default.
- W4214518311 citedByCount "1" @default.
- W4214518311 countsByYear W42145183112023 @default.
- W4214518311 crossrefType "journal-article" @default.
- W4214518311 hasAuthorship W4214518311A5036081621 @default.
- W4214518311 hasAuthorship W4214518311A5042450452 @default.
- W4214518311 hasAuthorship W4214518311A5050757664 @default.
- W4214518311 hasAuthorship W4214518311A5052054400 @default.
- W4214518311 hasAuthorship W4214518311A5060184761 @default.
- W4214518311 hasAuthorship W4214518311A5061191979 @default.
- W4214518311 hasAuthorship W4214518311A5070794803 @default.
- W4214518311 hasAuthorship W4214518311A5074620462 @default.
- W4214518311 hasAuthorship W4214518311A5082731232 @default.
- W4214518311 hasBestOaLocation W42145183111 @default.
- W4214518311 hasConcept C104317684 @default.
- W4214518311 hasConcept C126322002 @default.
- W4214518311 hasConcept C161176658 @default.
- W4214518311 hasConcept C169760540 @default.
- W4214518311 hasConcept C179335377 @default.
- W4214518311 hasConcept C18903297 @default.
- W4214518311 hasConcept C196843134 @default.
- W4214518311 hasConcept C2776077829 @default.
- W4214518311 hasConcept C2776784398 @default.
- W4214518311 hasConcept C2776878037 @default.
- W4214518311 hasConcept C2777500947 @default.
- W4214518311 hasConcept C2779234561 @default.
- W4214518311 hasConcept C2779491297 @default.
- W4214518311 hasConcept C2779547902 @default.
- W4214518311 hasConcept C2780384893 @default.
- W4214518311 hasConcept C29730261 @default.
- W4214518311 hasConcept C33070731 @default.
- W4214518311 hasConcept C46973012 @default.
- W4214518311 hasConcept C54355233 @default.
- W4214518311 hasConcept C71924100 @default.
- W4214518311 hasConcept C86803240 @default.
- W4214518311 hasConcept C98274493 @default.
- W4214518311 hasConceptScore W4214518311C104317684 @default.
- W4214518311 hasConceptScore W4214518311C126322002 @default.
- W4214518311 hasConceptScore W4214518311C161176658 @default.
- W4214518311 hasConceptScore W4214518311C169760540 @default.
- W4214518311 hasConceptScore W4214518311C179335377 @default.
- W4214518311 hasConceptScore W4214518311C18903297 @default.
- W4214518311 hasConceptScore W4214518311C196843134 @default.
- W4214518311 hasConceptScore W4214518311C2776077829 @default.
- W4214518311 hasConceptScore W4214518311C2776784398 @default.
- W4214518311 hasConceptScore W4214518311C2776878037 @default.
- W4214518311 hasConceptScore W4214518311C2777500947 @default.
- W4214518311 hasConceptScore W4214518311C2779234561 @default.
- W4214518311 hasConceptScore W4214518311C2779491297 @default.
- W4214518311 hasConceptScore W4214518311C2779547902 @default.
- W4214518311 hasConceptScore W4214518311C2780384893 @default.
- W4214518311 hasConceptScore W4214518311C29730261 @default.
- W4214518311 hasConceptScore W4214518311C33070731 @default.
- W4214518311 hasConceptScore W4214518311C46973012 @default.
- W4214518311 hasConceptScore W4214518311C54355233 @default.
- W4214518311 hasConceptScore W4214518311C71924100 @default.
- W4214518311 hasConceptScore W4214518311C86803240 @default.
- W4214518311 hasConceptScore W4214518311C98274493 @default.
- W4214518311 hasLocation W42145183111 @default.
- W4214518311 hasLocation W42145183112 @default.
- W4214518311 hasLocation W42145183113 @default.
- W4214518311 hasLocation W42145183114 @default.
- W4214518311 hasLocation W42145183115 @default.
- W4214518311 hasOpenAccess W4214518311 @default.
- W4214518311 hasPrimaryLocation W42145183111 @default.
- W4214518311 hasRelatedWork W1994410010 @default.
- W4214518311 hasRelatedWork W2046981883 @default.
- W4214518311 hasRelatedWork W2176913018 @default.
- W4214518311 hasRelatedWork W2373398108 @default.
- W4214518311 hasRelatedWork W2793891586 @default.
- W4214518311 hasRelatedWork W3046025531 @default.
- W4214518311 hasRelatedWork W4221066729 @default.
- W4214518311 hasRelatedWork W4230730570 @default.
- W4214518311 hasRelatedWork W4252413640 @default.
- W4214518311 hasRelatedWork W4362677256 @default.
- W4214518311 isParatext "false" @default.
- W4214518311 isRetracted "false" @default.
- W4214518311 workType "article" @default.