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- W4214522046 endingPage "2581" @default.
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- W4214522046 abstract "Galectins are soluble β-D-galactoside-binding proteins whose implication in cancer progression and disease outcome makes them prominent targets for therapeutic intervention. In this frame, the development of small inhibitors that block selectively the activity of galectins represents an important strategy for cancer therapy which is, however, still relatively underdeveloped. To this end, we designed here a rationally and efficiently novel diglycosylated compound, characterized by a selenoglycoside bond and the presence of a lipophilic benzyl group at both saccharide residues. The relatively high binding affinity of the new compound to the carbohydrate recognition domain of two galectins, galectin 3 and galectin 9, its good antiproliferative and anti-migration activity towards melanoma cells, as well as its anti-angiogenesis properties, pave the way for its further development as an anticancer agent." @default.
- W4214522046 created "2022-03-02" @default.
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- W4214522046 date "2022-02-25" @default.
- W4214522046 modified "2023-09-25" @default.
- W4214522046 title "Design, Synthesis, and Anticancer Activity of a Selenium-Containing Galectin-3 and Galectin-9N Inhibitor" @default.
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- W4214522046 doi "https://doi.org/10.3390/ijms23052581" @default.
- W4214522046 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35269724" @default.
- W4214522046 hasPublicationYear "2022" @default.
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