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- W4214523238 endingPage "100071" @default.
- W4214523238 startingPage "100071" @default.
- W4214523238 abstract "Immune checkpoint blockade (ICB) unleashes immune cells to attack tumors, thereby inducing durable clinical responses in many cancer types. The number of patients responding to ICB is modest, however, and combination treatments are likely needed to overcome the multifaceted suppressive pathways active in the tumor microenvironment (TME). The development of precision immuno-oncology (IO) strategies allowing to identify the optimal treatment of each patient upfront is therefore a pivotal question in the field of cancer immunotherapy. Although single-parameter biomarkers can enrich for response to ICB, their predictive capacity is far from perfect and their clinical utility is complicated by their continuous nature and the difficulty to determine cut-offs that reliably distinguish responding patients from those without clinical benefit. The antitumor immune response that is induced or reinvigorated by immunotherapy is a complex cascade of events requiring the interplay of multiple cell types. To move towards precision IO, it is therefore essential to understand for each individual patient at which level(s) the antitumor immune response failed and how it can be therapeutically restored. Holistic approaches to profile human tumor microenvironments and treatment-induced responses may help to identify critical rate-limiting factors of antitumor immunity. These factors need to be translated into clinically applicable multimodal predictors that allow for the selection of the best IO treatment. This review discusses strategies to (i) create such holistic views of antitumor immunity, (ii) identify measurable parameters capturing the complexity of a patient's immune status, and (iii) facilitate the incorporation of precision IO research in the clinic." @default.
- W4214523238 created "2022-03-02" @default.
- W4214523238 creator A5030512619 @default.
- W4214523238 creator A5061228349 @default.
- W4214523238 creator A5090385789 @default.
- W4214523238 date "2022-06-01" @default.
- W4214523238 modified "2023-10-09" @default.
- W4214523238 title "Multimodal predictors for precision immunotherapy" @default.
- W4214523238 cites W1483496013 @default.
- W4214523238 cites W1741548448 @default.
- W4214523238 cites W1940241680 @default.
- W4214523238 cites W1967954493 @default.
- W4214523238 cites W1994993231 @default.
- W4214523238 cites W2002513358 @default.
- W4214523238 cites W2007987850 @default.
- W4214523238 cites W2039123767 @default.
- W4214523238 cites W2044835625 @default.
- W4214523238 cites W2049553585 @default.
- W4214523238 cites W2053129129 @default.
- W4214523238 cites W2066671159 @default.
- W4214523238 cites W2074175804 @default.
- W4214523238 cites W2097855813 @default.
- W4214523238 cites W2104885590 @default.
- W4214523238 cites W2107429737 @default.
- W4214523238 cites W2124427232 @default.
- W4214523238 cites W2125616358 @default.
- W4214523238 cites W2152897456 @default.
- W4214523238 cites W2157824068 @default.
- W4214523238 cites W2160834915 @default.
- W4214523238 cites W2169071929 @default.
- W4214523238 cites W2170137783 @default.
- W4214523238 cites W2198641185 @default.
- W4214523238 cites W2290349987 @default.
- W4214523238 cites W2299181842 @default.
- W4214523238 cites W2337659275 @default.
- W4214523238 cites W2346108121 @default.
- W4214523238 cites W2473498748 @default.
- W4214523238 cites W2504623699 @default.
- W4214523238 cites W2521690972 @default.
- W4214523238 cites W2524881570 @default.
- W4214523238 cites W2528849844 @default.
- W4214523238 cites W2529896336 @default.
- W4214523238 cites W2560367415 @default.
- W4214523238 cites W2578528809 @default.
- W4214523238 cites W2582362986 @default.
- W4214523238 cites W2605630275 @default.
- W4214523238 cites W2622499649 @default.
- W4214523238 cites W2655262992 @default.
- W4214523238 cites W2747774814 @default.
- W4214523238 cites W2759958021 @default.
- W4214523238 cites W2761575992 @default.
- W4214523238 cites W2766123339 @default.
- W4214523238 cites W2766985996 @default.
- W4214523238 cites W2773981699 @default.
- W4214523238 cites W2779221466 @default.
- W4214523238 cites W2788735115 @default.
- W4214523238 cites W2790574591 @default.
- W4214523238 cites W2800047488 @default.
- W4214523238 cites W2802206159 @default.
- W4214523238 cites W2804073610 @default.
- W4214523238 cites W2807534769 @default.
- W4214523238 cites W2885650843 @default.
- W4214523238 cites W2886498337 @default.
- W4214523238 cites W2887187316 @default.
- W4214523238 cites W2889555301 @default.
- W4214523238 cites W2890156321 @default.
- W4214523238 cites W2894796660 @default.
- W4214523238 cites W2896450660 @default.
- W4214523238 cites W2898830231 @default.
- W4214523238 cites W2899145148 @default.
- W4214523238 cites W2901850955 @default.
- W4214523238 cites W2905447079 @default.
- W4214523238 cites W2907549567 @default.
- W4214523238 cites W2908581980 @default.
- W4214523238 cites W2909486828 @default.
- W4214523238 cites W2910806811 @default.
- W4214523238 cites W2913558101 @default.
- W4214523238 cites W2914458127 @default.
- W4214523238 cites W2916647762 @default.
- W4214523238 cites W2922154162 @default.
- W4214523238 cites W2939543377 @default.
- W4214523238 cites W2947862269 @default.
- W4214523238 cites W2947923969 @default.
- W4214523238 cites W2949238013 @default.
- W4214523238 cites W2957195898 @default.
- W4214523238 cites W2961686530 @default.
- W4214523238 cites W2966465234 @default.
- W4214523238 cites W2976525441 @default.
- W4214523238 cites W2977392388 @default.
- W4214523238 cites W2980113327 @default.
- W4214523238 cites W2980909418 @default.
- W4214523238 cites W2983182405 @default.
- W4214523238 cites W2997277554 @default.
- W4214523238 cites W2998795792 @default.
- W4214523238 cites W3000282923 @default.
- W4214523238 cites W3000311037 @default.
- W4214523238 cites W3005326482 @default.
- W4214523238 cites W3009070575 @default.