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- W4214525262 abstract "Abstract Lactate is a glycolytic product and a significant energy source. Moreover, it regulates gene transcription via lactylation of histones and non-histone proteins, i.e., a novel posttranslational modification. This review summarizes recent advances related to lactylation in lactate metabolism and diseases. Notably, lactylation plays a vital role in cancer, inflammation, and regeneration; however, the specific mechanism remains unclear. Histone lactylation regulates oncogenic processes by targeting gene transcription and inflammation via macrophage activation. Eventually, we identified research gaps and recommended several primary directions for further studies." @default.
- W4214525262 created "2022-03-02" @default.
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- W4214525262 date "2022-02-27" @default.
- W4214525262 modified "2023-10-16" @default.
- W4214525262 title "Lactylation: a Passing Fad or the Future of Posttranslational Modification" @default.
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- W4214525262 doi "https://doi.org/10.1007/s10753-022-01637-w" @default.
- W4214525262 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35224683" @default.
- W4214525262 hasPublicationYear "2022" @default.
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