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- W4214531400 abstract "The medicinally important species of the Solanaceae family belong to genera viz., Solanum, Atropa, Datura, Hyoscyamus, Nicotiana, etc. The active phytoalkaloids which are present in them are tropane, pyrrolidine–pyridine, and steroid alkaloids. Some of the pharmacologically potent alkaloids are scopolamine, atropine, hyoscyamine, nicotine, cocaine, solanidine, and solasodine. Tropane alkaloids, their semisynthetic, and synthetic derivatives are used as antispasmodic, antiemetic, mydriatic, and bronchodilator because of anticholinergic actions. Compounds with tropane nuclei bearing diester group on their structure without quaternary ammonium have shown local anesthetic and CNS stimulant actions. Nicotine is a pyrrolidine–pyridine alkaloid that acts on nicotinic receptors. Steroidal alkaloids like solasodine are poisonous and serve as starting material for the synthesis of steroidal hormones. This chapter describes general methods of extraction and isolation of alkaloids. The sources, classification, pharmacological actions, and structure–activity relationship of tropane alkaloids are illustrated with a special emphasis on chemical structure elucidation of atropine." @default.
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- W4214531400 date "2022-01-01" @default.
- W4214531400 modified "2023-10-12" @default.
- W4214531400 title "Isolation, elucidation, and structure–activity relationships of phytoalkaloids from Solanaceae" @default.
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- W4214531400 doi "https://doi.org/10.1016/b978-0-12-823944-5.00007-7" @default.
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