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- W4214534900 endingPage "136560" @default.
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- W4214534900 abstract "The estrogen (17β-estradiol, E2) level in the hippocampus is higher and more stable in male rats than female rats. Both stress and estrogen affect spine plasticity, and many studies have demonstrated that peripheral estrogen treatment can prevent stress-induced spine loss in both males and females. Some in vitro studies have indicated that neural estrogen (nE2) participates in the modulation of spine plasticity in cultured neurons. However, whether nE2 regulates spine density in vivo in males is not clear, and the specific role of nE2 in stress-induced depression-like behaviors of male rats remains unknown. We delivered letrozole (a selective aromatase inhibitor that blocks the conversion of testosterone to estradiol) and estrogen into the hippocampus of rats and found that letrozole treatment induced the same depression-like behaviors in control rats as observed in chronic unpredictable mild stress (CUMS) rats. Estrogen treatment reversed/or alleviated depression-like behaviors induced by CUMS or letrozole infusion and elevated Kalirin-7 expression in hippocampus. Estrogen treatment also rescued letrozole-induced spine loss. Expression of GluN1 and PSD-95 also changed with Kalirin-7 and spine density. All these proteins were decreased in CUMS rats and letrozole infusion rats but increased in rats treated with estrogen. In conclusion, nE2 in the hippocampus plays an important role in CUMS-induced depression-like behaviors in male rats and Kalirin-7 is involved in this process. GluN1 and PSD-95 possibly mediate the regulation of Kalirin-7 by nE2, which ultimately leads to changes in spine density and depression-like behaviors." @default.
- W4214534900 created "2022-03-02" @default.
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- W4214534900 date "2022-08-01" @default.
- W4214534900 modified "2023-10-16" @default.
- W4214534900 title "Endogenous hippocampal estrogen is involved in stress-induced depression-like behaviors and spine plasticity in male rats" @default.
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- W4214534900 doi "https://doi.org/10.1016/j.neulet.2022.136560" @default.
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