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- W4214541295 abstract "Ependymoma is the third most common pediatric tumor with posterior fossa group A (PFA) being its most aggressive subtype. Ependymomas are generally refractory to chemotherapies and thus lack any effective treatment. Here, we report that elevated expression of CXorf67 (chromosome X open reading frame 67), which frequently occurs in PFA ependymomas, suppresses homologous recombination (HR)-mediated DNA repair. Mechanistically, CXorf67 interacts with PALB2 and inhibits PALB2-BRCA2 interaction, thereby inhibiting HR repair. Concordantly, tumor cells with high CXorf67 expression levels show increased sensitivity to poly(ADP-ribose) polymerase (PARP) inhibitors, especially when combined with radiotherapy. Thus, our findings have revealed a role of CXorf67 in HR repair and suggest that combination of PARP inhibitors with radiotherapy could be an effective treatment option for PFA ependymomas.Copyright © 2020 Elsevier Inc. All rights reserved. PMID: 33186520" @default.
- W4214541295 created "2022-03-02" @default.
- W4214541295 creator A5035184461 @default.
- W4214541295 creator A5048423328 @default.
- W4214541295 date "2021-01-25" @default.
- W4214541295 modified "2023-10-18" @default.
- W4214541295 title "Faculty Opinions recommendation of Elevated cxorf67 expression in PFA ependymomas suppresses DNA repair and sensitizes to PARP inhibitors." @default.
- W4214541295 doi "https://doi.org/10.3410/f.739027809.793582192" @default.
- W4214541295 hasPublicationYear "2021" @default.
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