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- W4214558102 abstract "Protein secretion is a common property of pathogenic microbes. Gram-negative bacterial pathogens use at least 6 distinct extracellular protein secretion systems to export proteins through their multilayered cell envelope and in some cases into host cells. Among the most widespread is the newly recognized Type VI secretion system (T6SS) which is composed of 15-20 proteins whose biochemical functions are not well understood. Using crystallographic, biochemical, and bioinformatic analyses, we identified 3 T6SS components, which are homologous to bacteriophage tail proteins. These include the tail tube protein; the membrane-penetrating needle, situated at the distal end of the tube; and another protein associated with the needle and tube. We propose that T6SS is a multicomponent structure whose extracellular part resembles both structurally and functionally a bacteriophage tail, an efficient machine that translocates proteins and DNA across lipid membranes into cells. PMID: 19251641 Funding information This work was supported by: NIAID NIH HHS, United States Grant ID: AI-18045 NIAID NIH HHS, United States Grant ID: AI-26289 NIAID NIH HHS, United States Grant ID: R01 AI018045 NIGMS NIH HHS, United States Grant ID: U54 GM074945 NIAID NIH HHS, United States Grant ID: R37 AI018045 NIAID NIH HHS, United States Grant ID: R01 AI026289 More Less keyboard_arrow_down" @default.
- W4214558102 created "2022-03-02" @default.
- W4214558102 creator A5031492621 @default.
- W4214558102 date "2013-11-20" @default.
- W4214558102 modified "2023-09-23" @default.
- W4214558102 title "Faculty Opinions recommendation of Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin." @default.
- W4214558102 doi "https://doi.org/10.3410/f.1158739.793487059" @default.
- W4214558102 hasPublicationYear "2013" @default.
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