Matches in SemOpenAlex for { <https://semopenalex.org/work/W4214567718> ?p ?o ?g. }
- W4214567718 abstract "Abstract Rod bipolar cells (rBCs) represent a promising target for vision restoration as they relay information to the major image processing pathways in the retina. However, the diversity of the retinal output and the resolution obtained by optogenetic actuation of rBCs is unclear. Herein, the photostimulation of rBCs expressing channelrhodopsin‐2 is studied in a transgenic, photoreceptor‐degeneration mouse (rd10) while simultaneously recording the retinal output using a high‐density microelectrode array. After analyzing several hundred retinal output neurons, both optogenetic ON and OFF type responses are identified at similar ratio at stimulation thresholds well below photodamage intensity. The temporal latency of both response types is in the same range ( 50 ms) as reported for healthy mouse retinal ganglion cells. The spatial resolution ranges between 0.1 and 0.2 cycles deg ‐1 , which is close to that found in healthy mice. Photostimulation over an extended area (29 deg) but not localized stimuli induces strong bursting activity, which may originate from large‐scale activation of a coupled network of retinal cells. The distinct ON and OFF optogenetically induced activity patterns in retinal ganglion cells and the high temporal and spatial resolution demonstrate that near‐physiological vision restoration may be achieved under optimal conditions in late stage retinal degeneration." @default.
- W4214567718 created "2022-03-02" @default.
- W4214567718 creator A5013070983 @default.
- W4214567718 creator A5074252745 @default.
- W4214567718 creator A5080445092 @default.
- W4214567718 date "2022-02-27" @default.
- W4214567718 modified "2023-10-16" @default.
- W4214567718 title "Expression of Channelrhodopsin‐2 in Rod Bipolar Cells Restores ON and OFF Responses at High Spatial Resolution in Blind Mouse Retina" @default.
- W4214567718 cites W1531428978 @default.
- W4214567718 cites W1536858825 @default.
- W4214567718 cites W1544975792 @default.
- W4214567718 cites W1561688810 @default.
- W4214567718 cites W1564717701 @default.
- W4214567718 cites W1602094372 @default.
- W4214567718 cites W1939828159 @default.
- W4214567718 cites W1969161729 @default.
- W4214567718 cites W1973887584 @default.
- W4214567718 cites W1974565469 @default.
- W4214567718 cites W1979802895 @default.
- W4214567718 cites W1985304131 @default.
- W4214567718 cites W1991693279 @default.
- W4214567718 cites W1997384917 @default.
- W4214567718 cites W1998765922 @default.
- W4214567718 cites W1999311112 @default.
- W4214567718 cites W2003965293 @default.
- W4214567718 cites W2006028506 @default.
- W4214567718 cites W2012271461 @default.
- W4214567718 cites W2025153330 @default.
- W4214567718 cites W2029912485 @default.
- W4214567718 cites W2032000491 @default.
- W4214567718 cites W2037084455 @default.
- W4214567718 cites W2041457575 @default.
- W4214567718 cites W2047141148 @default.
- W4214567718 cites W2048044998 @default.
- W4214567718 cites W2062620004 @default.
- W4214567718 cites W2070162220 @default.
- W4214567718 cites W2074147019 @default.
- W4214567718 cites W2079319133 @default.
- W4214567718 cites W2086705852 @default.
- W4214567718 cites W2090651497 @default.
- W4214567718 cites W2092857340 @default.
- W4214567718 cites W2093109528 @default.
- W4214567718 cites W2094975664 @default.
- W4214567718 cites W2099153171 @default.
- W4214567718 cites W2100612658 @default.
- W4214567718 cites W2123215356 @default.
- W4214567718 cites W2140320479 @default.
- W4214567718 cites W2150645972 @default.
- W4214567718 cites W2158310183 @default.
- W4214567718 cites W2159198041 @default.
- W4214567718 cites W2159423248 @default.
- W4214567718 cites W2167392460 @default.
- W4214567718 cites W2201974140 @default.
- W4214567718 cites W2261405855 @default.
- W4214567718 cites W2277500787 @default.
- W4214567718 cites W2301247560 @default.
- W4214567718 cites W2468280347 @default.
- W4214567718 cites W2495196232 @default.
- W4214567718 cites W2509583655 @default.
- W4214567718 cites W2534549821 @default.
- W4214567718 cites W2613695739 @default.
- W4214567718 cites W2753853310 @default.
- W4214567718 cites W2766951147 @default.
- W4214567718 cites W2767768843 @default.
- W4214567718 cites W2801908338 @default.
- W4214567718 cites W2807168810 @default.
- W4214567718 cites W2901008034 @default.
- W4214567718 cites W3011950580 @default.
- W4214567718 cites W3024345744 @default.
- W4214567718 cites W3027866089 @default.
- W4214567718 cites W3087663490 @default.
- W4214567718 cites W3094320875 @default.
- W4214567718 cites W3122468798 @default.
- W4214567718 cites W3125280579 @default.
- W4214567718 cites W3128332752 @default.
- W4214567718 cites W4245474015 @default.
- W4214567718 cites W836249930 @default.
- W4214567718 doi "https://doi.org/10.1002/adtp.202100164" @default.
- W4214567718 hasPublicationYear "2022" @default.
- W4214567718 type Work @default.
- W4214567718 citedByCount "2" @default.
- W4214567718 countsByYear W42145677182022 @default.
- W4214567718 crossrefType "journal-article" @default.
- W4214567718 hasAuthorship W4214567718A5013070983 @default.
- W4214567718 hasAuthorship W4214567718A5074252745 @default.
- W4214567718 hasAuthorship W4214567718A5080445092 @default.
- W4214567718 hasConcept C111670793 @default.
- W4214567718 hasConcept C12554922 @default.
- W4214567718 hasConcept C147789679 @default.
- W4214567718 hasConcept C169760540 @default.
- W4214567718 hasConcept C17525397 @default.
- W4214567718 hasConcept C185592680 @default.
- W4214567718 hasConcept C202033177 @default.
- W4214567718 hasConcept C24998067 @default.
- W4214567718 hasConcept C2777093970 @default.
- W4214567718 hasConcept C2777624874 @default.
- W4214567718 hasConcept C2780827179 @default.
- W4214567718 hasConcept C2781040256 @default.
- W4214567718 hasConcept C2781151714 @default.
- W4214567718 hasConcept C30028475 @default.