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- W4214568462 abstract "Biological systems tailor their properties and behavior to their size throughout development and in numerous aspects of physiology. However, such size scaling remains poorly understood as it applies to cell mechanics and mechanosensing. By examining how the Drosophila pupal dorsal thorax epithelium responds to morphogenetic forces, we found that the number of apical stress fibers (aSFs) anchored to adherens junctions scales with cell apical area to limit larger cell elongation under mechanical stress. aSFs cluster Hippo pathway components, thereby scaling Hippo signaling and proliferation with area. This scaling is promoted by tricellular junctions mediating an increase in aSF nucleation rate and lifetime in larger cells. Development, homeostasis, and repair entail epithelial cell size changes driven by mechanical forces; our work highlights how, in turn, mechanosensitivity scales with cell size.Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. PMID: 33060329" @default.
- W4214568462 created "2022-03-02" @default.
- W4214568462 creator A5026415994 @default.
- W4214568462 date "2020-10-29" @default.
- W4214568462 modified "2023-09-27" @default.
- W4214568462 title "Faculty Opinions recommendation of Apical stress fibers enable a scaling between cell mechanical response and area in epithelial tissue." @default.
- W4214568462 doi "https://doi.org/10.3410/f.738843868.793579781" @default.
- W4214568462 hasPublicationYear "2020" @default.
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