FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4214572067> ?p ?o ?g. }

• W4214572067 endingPage "533" @default.
• W4214572067 startingPage "533" @default.
• W4214572067 abstract "In this study, we examined the anti-tumor effects of heat-killed Bifidobacterium and Lactobacillus strains on human colorectal carcinoma RKO cells in in vitro and in vivo xenograft models. First, the cytotoxic and apoptotic effects of 11 different strains were examined using an MTT assay and flow cytometry, respectively. Then, xenograft BALB/c nude mice were implanted with RKO cells and orally administered with single or mixed heat-killed bacterial strains to examine their inhibitory effects on tumor growth. Additionally, the levels of cleaved caspase-9, -3, and -7 and PARP in tumor tissues were analyzed using Western blotting or immunohistochemistry staining. The results showed that RKO cells were highly susceptible to heat-killed B. bifidum MG731 and L. reuteri MG5346 and that L. casei MG4584 induced apoptosis to a greater extent than other strains. The oral administration of individual MG731, MG5346, or MG4584 significantly delayed tumor growth, and mixtures of MG5346 and MG4584 or MG731, MG5346, and MG4584 synergistically inhibited the tumor growth in the xenograft model. The expression of cleaved caspase-3, -7, and -9 and PARP in the tumor tissues was increased in Western blotting, and the expression of cleaved caspase-3 and PARP in immunohistochemistry staining was also increased. Therefore, we suggest that the use of the combination of MG5346 and MG4584 as parabiotics could effectively inhibit the growth of colorectal cancer." @default.
• W4214572067 created "2022-03-02" @default.
• W4214572067 creator A5001100010 @default.
• W4214572067 creator A5010214504 @default.
• W4214572067 creator A5083651391 @default.
• W4214572067 creator A5089053629 @default.
• W4214572067 date "2022-02-28" @default.
• W4214572067 modified "2023-10-16" @default.
• W4214572067 title "Anti-Tumor Effects of Heat-Killed L. reuteri MG5346 and L. casei MG4584 against Human Colorectal Carcinoma through Caspase-9-Dependent Apoptosis in Xenograft Model" @default.
• W4214572067 cites W1984143791 @default.
• W4214572067 cites W1995437219 @default.
• W4214572067 cites W2024211659 @default.
• W4214572067 cites W2037545733 @default.
• W4214572067 cites W2037613441 @default.
• W4214572067 cites W2095625773 @default.
• W4214572067 cites W2119304949 @default.
• W4214572067 cites W2138466194 @default.
• W4214572067 cites W2171843410 @default.
• W4214572067 cites W2227234059 @default.
• W4214572067 cites W2339460657 @default.
• W4214572067 cites W2417756147 @default.
• W4214572067 cites W2491844534 @default.
• W4214572067 cites W2586778891 @default.
• W4214572067 cites W2605731956 @default.
• W4214572067 cites W2762997972 @default.
• W4214572067 cites W2790256881 @default.
• W4214572067 cites W2923287877 @default.
• W4214572067 cites W2938357920 @default.
• W4214572067 cites W2946487898 @default.
• W4214572067 cites W2948210547 @default.
• W4214572067 cites W2955577995 @default.
• W4214572067 cites W2962206784 @default.
• W4214572067 cites W2971713670 @default.
• W4214572067 cites W2974408176 @default.
• W4214572067 cites W2987088324 @default.
• W4214572067 cites W3000057015 @default.
• W4214572067 cites W3014462210 @default.
• W4214572067 cites W3024495812 @default.
• W4214572067 cites W3035559061 @default.
• W4214572067 cites W3059301501 @default.
• W4214572067 cites W3119409060 @default.
• W4214572067 cites W3127045384 @default.
• W4214572067 cites W4200065008 @default.
• W4214572067 doi "https://doi.org/10.3390/microorganisms10030533" @default.
• W4214572067 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35336106" @default.
• W4214572067 hasPublicationYear "2022" @default.
• W4214572067 type Work @default.
• W4214572067 citedByCount "13" @default.
• W4214572067 countsByYear W42145720672022 @default.
• W4214572067 countsByYear W42145720672023 @default.
• W4214572067 crossrefType "journal-article" @default.
• W4214572067 hasAuthorship W4214572067A5001100010 @default.
• W4214572067 hasAuthorship W4214572067A5010214504 @default.
• W4214572067 hasAuthorship W4214572067A5083651391 @default.
• W4214572067 hasAuthorship W4214572067A5089053629 @default.
• W4214572067 hasBestOaLocation W42145720671 @default.
• W4214572067 hasConcept C100544194 @default.
• W4214572067 hasConcept C104317684 @default.
• W4214572067 hasConcept C121608353 @default.
• W4214572067 hasConcept C126322002 @default.
• W4214572067 hasConcept C150903083 @default.
• W4214572067 hasConcept C153911025 @default.
• W4214572067 hasConcept C185592680 @default.
• W4214572067 hasConcept C190283241 @default.
• W4214572067 hasConcept C203014093 @default.
• W4214572067 hasConcept C204232928 @default.
• W4214572067 hasConcept C207001950 @default.
• W4214572067 hasConcept C2776662696 @default.
• W4214572067 hasConcept C2780783641 @default.
• W4214572067 hasConcept C34688535 @default.
• W4214572067 hasConcept C502942594 @default.
• W4214572067 hasConcept C526805850 @default.
• W4214572067 hasConcept C553184892 @default.
• W4214572067 hasConcept C55493867 @default.
• W4214572067 hasConcept C71924100 @default.
• W4214572067 hasConcept C85265743 @default.
• W4214572067 hasConcept C86803240 @default.
• W4214572067 hasConceptScore W4214572067C100544194 @default.
• W4214572067 hasConceptScore W4214572067C104317684 @default.
• W4214572067 hasConceptScore W4214572067C121608353 @default.
• W4214572067 hasConceptScore W4214572067C126322002 @default.
• W4214572067 hasConceptScore W4214572067C150903083 @default.
• W4214572067 hasConceptScore W4214572067C153911025 @default.
• W4214572067 hasConceptScore W4214572067C185592680 @default.
• W4214572067 hasConceptScore W4214572067C190283241 @default.
• W4214572067 hasConceptScore W4214572067C203014093 @default.
• W4214572067 hasConceptScore W4214572067C204232928 @default.
• W4214572067 hasConceptScore W4214572067C207001950 @default.
• W4214572067 hasConceptScore W4214572067C2776662696 @default.
• W4214572067 hasConceptScore W4214572067C2780783641 @default.
• W4214572067 hasConceptScore W4214572067C34688535 @default.
• W4214572067 hasConceptScore W4214572067C502942594 @default.
• W4214572067 hasConceptScore W4214572067C526805850 @default.
• W4214572067 hasConceptScore W4214572067C553184892 @default.
• W4214572067 hasConceptScore W4214572067C55493867 @default.
• W4214572067 hasConceptScore W4214572067C71924100 @default.
• W4214572067 hasConceptScore W4214572067C85265743 @default.
• W4214572067 hasConceptScore W4214572067C86803240 @default.

• next