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- W4214572941 abstract "This chapter summarizes basic membrane properties of thalamic and cortical neurons, starting with a consideration of current flow within these cells based on modeling of the somadendritic tree as a series of branched cables with leaky membranes. This assumes passive membrane properties and provides some useful first approximations of neuronal functioning, but these neurons have a number of active ionic conductances that are also described and play important roles in neuronal activity. These involve various ligand-, voltage-, and time-dependent ion channels. The ubiquitous voltage- and time-dependent Na<sup>+</sup> channel underlying the action potential is the best known example of such channels, and these are found virtually in all thalamic and cortical neurons. Another important voltage- and time-dependent channel is the T-type Ca<sup>2+</sup> channel, and thalamic neurons are relatively unique in having these channels distributed so densely in their somadendritic membranes that, when evoked, they can produce all-or-none Ca<sup>2+</sup> spikes that propagate through the soma and dendrites; these spikes, in turn, evoke a burst of conventional action potentials. Some cortical cells show similar burst firing based on a different voltage- and time-dependent Ca<sup>2+</sup> channel. Details of these processes and speculation of their functional significance are discussed." @default.
- W4214572941 created "2022-03-02" @default.
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- W4214572941 date "2021-09-01" @default.
- W4214572941 modified "2023-09-26" @default.
- W4214572941 title "Intrinsic Membrane Properties" @default.
- W4214572941 doi "https://doi.org/10.1093/med/9780197503874.003.0003" @default.
- W4214572941 hasPublicationYear "2021" @default.
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