Matches in SemOpenAlex for { <https://semopenalex.org/work/W4214575800> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W4214575800 abstract "Background and Purpose: Obesity and Type 2 Diabetes are major causes of morbidity-mortality characterized by mitochondrial dysfunction and oxidative-nitrosative stress. Despite intensive research, the events that cause the onset and progression of these diseases are not completely understood. Herein, we investigated if dysregulation of mitochondrial dynamics and biogenesis is involved in an animal model of obesity and diabetes. Experimental Approach: Mitochondrial dynamics and biogenesis were evaluated in epididymal white adipose tissue and adipocytes from ob/ob mice, an animal model of obesity and diabetes, pharmacological treatment with mdvi-1, a selective inhibitor of Drp1 and leptin. Key Results: A decrease of Mfn2 and OPA-1 protein expression and an increase in Drp1- protein levels were observed with enhanced and sustained mitochondrial fragmentation in ob/ob mice compared to wt C57BL/6 animals. The content of mitochondrial DNA and mRNA expression of PGC-1α, both parameters of mitochondrial biogenesis, were reduced in ob/ob mice. The treatment with leptin or mdvi-1 (Drp1 inhibitor) significantly increased abnormal biogenesis, improved fusion-to-fission balance and attenuated mitochondrial dysfunction, and adipogenesis, thus inducing white-to-beige adipocyte transdifferentiation. Measurements of glucose and lipid oxidation in adipocytes revealed that both leptin and mdvi-1 increase substrates oxidation while in vivo determination of blood glucose showed decreased blood glucose concentration by 50 % in ob/ob mice, almost to the wt level. Conclusion and Implications: In light of these results, pharmacological targeting of Drp1 may be a potential novel therapeutic tool for obesity and diabetes." @default.
- W4214575800 created "2022-03-02" @default.
- W4214575800 creator A5001727798 @default.
- W4214575800 creator A5008353232 @default.
- W4214575800 creator A5012281106 @default.
- W4214575800 creator A5013264736 @default.
- W4214575800 creator A5016524012 @default.
- W4214575800 creator A5026011199 @default.
- W4214575800 creator A5032148720 @default.
- W4214575800 creator A5045024628 @default.
- W4214575800 creator A5066080665 @default.
- W4214575800 creator A5085658697 @default.
- W4214575800 creator A5087738712 @default.
- W4214575800 date "2020-07-27" @default.
- W4214575800 modified "2023-09-26" @default.
- W4214575800 title "Inhibition of Mitochondrial Fission by Drp-1 Blockade Improves White Adipose Tissue Abnormalities in Obesity and Diabetes" @default.
- W4214575800 doi "https://doi.org/10.22541/au.159586069.98939770" @default.
- W4214575800 hasPublicationYear "2020" @default.
- W4214575800 type Work @default.
- W4214575800 citedByCount "0" @default.
- W4214575800 crossrefType "posted-content" @default.
- W4214575800 hasAuthorship W4214575800A5001727798 @default.
- W4214575800 hasAuthorship W4214575800A5008353232 @default.
- W4214575800 hasAuthorship W4214575800A5012281106 @default.
- W4214575800 hasAuthorship W4214575800A5013264736 @default.
- W4214575800 hasAuthorship W4214575800A5016524012 @default.
- W4214575800 hasAuthorship W4214575800A5026011199 @default.
- W4214575800 hasAuthorship W4214575800A5032148720 @default.
- W4214575800 hasAuthorship W4214575800A5045024628 @default.
- W4214575800 hasAuthorship W4214575800A5066080665 @default.
- W4214575800 hasAuthorship W4214575800A5085658697 @default.
- W4214575800 hasAuthorship W4214575800A5087738712 @default.
- W4214575800 hasBestOaLocation W42145758001 @default.
- W4214575800 hasConcept C104317684 @default.
- W4214575800 hasConcept C122927707 @default.
- W4214575800 hasConcept C126322002 @default.
- W4214575800 hasConcept C134018914 @default.
- W4214575800 hasConcept C151955695 @default.
- W4214575800 hasConcept C163950672 @default.
- W4214575800 hasConcept C171089720 @default.
- W4214575800 hasConcept C17619807 @default.
- W4214575800 hasConcept C24586158 @default.
- W4214575800 hasConcept C2776782570 @default.
- W4214575800 hasConcept C2777092462 @default.
- W4214575800 hasConcept C2777180221 @default.
- W4214575800 hasConcept C2777229759 @default.
- W4214575800 hasConcept C2777391703 @default.
- W4214575800 hasConcept C2777755479 @default.
- W4214575800 hasConcept C2780613262 @default.
- W4214575800 hasConcept C28859421 @default.
- W4214575800 hasConcept C511355011 @default.
- W4214575800 hasConcept C55493867 @default.
- W4214575800 hasConcept C555293320 @default.
- W4214575800 hasConcept C71924100 @default.
- W4214575800 hasConcept C86803240 @default.
- W4214575800 hasConcept C95444343 @default.
- W4214575800 hasConceptScore W4214575800C104317684 @default.
- W4214575800 hasConceptScore W4214575800C122927707 @default.
- W4214575800 hasConceptScore W4214575800C126322002 @default.
- W4214575800 hasConceptScore W4214575800C134018914 @default.
- W4214575800 hasConceptScore W4214575800C151955695 @default.
- W4214575800 hasConceptScore W4214575800C163950672 @default.
- W4214575800 hasConceptScore W4214575800C171089720 @default.
- W4214575800 hasConceptScore W4214575800C17619807 @default.
- W4214575800 hasConceptScore W4214575800C24586158 @default.
- W4214575800 hasConceptScore W4214575800C2776782570 @default.
- W4214575800 hasConceptScore W4214575800C2777092462 @default.
- W4214575800 hasConceptScore W4214575800C2777180221 @default.
- W4214575800 hasConceptScore W4214575800C2777229759 @default.
- W4214575800 hasConceptScore W4214575800C2777391703 @default.
- W4214575800 hasConceptScore W4214575800C2777755479 @default.
- W4214575800 hasConceptScore W4214575800C2780613262 @default.
- W4214575800 hasConceptScore W4214575800C28859421 @default.
- W4214575800 hasConceptScore W4214575800C511355011 @default.
- W4214575800 hasConceptScore W4214575800C55493867 @default.
- W4214575800 hasConceptScore W4214575800C555293320 @default.
- W4214575800 hasConceptScore W4214575800C71924100 @default.
- W4214575800 hasConceptScore W4214575800C86803240 @default.
- W4214575800 hasConceptScore W4214575800C95444343 @default.
- W4214575800 hasLocation W42145758001 @default.
- W4214575800 hasOpenAccess W4214575800 @default.
- W4214575800 hasPrimaryLocation W42145758001 @default.
- W4214575800 hasRelatedWork W2008460293 @default.
- W4214575800 hasRelatedWork W2594293682 @default.
- W4214575800 hasRelatedWork W2729162541 @default.
- W4214575800 hasRelatedWork W2766219070 @default.
- W4214575800 hasRelatedWork W2981431241 @default.
- W4214575800 hasRelatedWork W4296311848 @default.
- W4214575800 hasRelatedWork W4321003796 @default.
- W4214575800 hasRelatedWork W4360863522 @default.
- W4214575800 hasRelatedWork W650810029 @default.
- W4214575800 hasRelatedWork W2397878586 @default.
- W4214575800 isParatext "false" @default.
- W4214575800 isRetracted "false" @default.
- W4214575800 workType "article" @default.