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- W4214591153 abstract "Genetic association results are often interpreted with the assumption that study participation does not affect downstream analyses. Understanding the genetic basis of participation bias is challenging since it requires the genotypes of unseen individuals. Here we demonstrate that it is possible to estimate comparative biases by performing a genome-wide association study contrasting one subgroup versus another. For example, we showed that sex exhibits artifactual autosomal heritability in the presence of sex-differential participation bias. By performing a genome-wide association study of sex in approximately 3.3 million males and females, we identified over 158 autosomal loci spuriously associated with sex and highlighted complex traits underpinning differences in study participation between the sexes. For example, the body mass index-increasing allele at FTO was observed at higher frequency in males compared to females (odds ratio = 1.02, P = 4.4 × 10-36). Finally, we demonstrated how these biases can potentially lead to incorrect inferences in downstream analyses and propose a conceptual framework for addressing such biases. Our findings highlight a new challenge that genetic studies may face as sample sizes continue to grow. PMID: 33888908 Funding information This work was supported by: Medical Research Council, United Kingdom Grant ID: MC_UU_12015/2" @default.
- W4214591153 created "2022-03-02" @default.
- W4214591153 creator A5036776618 @default.
- W4214591153 date "2021-05-16" @default.
- W4214591153 modified "2023-09-25" @default.
- W4214591153 title "Faculty Opinions recommendation of Genetic analyses identify widespread sex-differential participation bias." @default.
- W4214591153 doi "https://doi.org/10.3410/f.739980007.793585643" @default.
- W4214591153 hasPublicationYear "2021" @default.
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