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- W4214595215 abstract "Abstract The age‐associated decline in female fertility is largely ascribable to a decrease in oocyte quality. This phenomenon is multifaceted and influenced by numerous interconnected maternal and environmental factors. An increase in the rate of meiotic errors is the major cause of the decline in oocyte developmental competence. However, abnormalities in the ooplasm accumulating with age — including altered metabolism, organelle dysfunction, and aberrant gene regulation — progressively undermine oocyte quality. Stockpiling of maternal macromolecules during folliculogenesis is crucial, as oocyte competence to achieve maturation, fertilization, and the earliest phases of embryo development occur in absence of transcription. At the same time, crucial remodeling of oocyte epigenetics during oogenesis is potentially exposed to interfering factors, such as assisted reproduction technologies (ARTs) or environmental changes, whose impact may be enhanced by reproductive aging. As the effects of maternal aging on molecular mechanisms governing the function of the human oocyte remain poorly understood, studies in animal models are essential to deepen current understanding, with translational implications for human ARTs. The present mini review aims at offering an updated and consistent view of cytoplasmic alterations occurring in oocytes during aging, focusing particularly on gene and epigenetic regulation. Appreciation of these mechanisms could inspire solutions to mitigate/control the phenomenon, and thus benefit modern ARTs." @default.
- W4214595215 created "2022-03-02" @default.
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- W4214595215 creator A5051476729 @default.
- W4214595215 creator A5077634975 @default.
- W4214595215 date "2022-02-25" @default.
- W4214595215 modified "2023-10-17" @default.
- W4214595215 title "Oocyte aging: looking beyond chromosome segregation errors" @default.
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- W4214595215 doi "https://doi.org/10.1007/s10815-022-02441-z" @default.
- W4214595215 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35212880" @default.
- W4214595215 hasPublicationYear "2022" @default.
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