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• W4214605016 abstract "Deregulation of micro(mi)-RNAs is a common mechanism in tumorigenesis. We investigated the expression of 2083 miRNAs in T-cell prolymphocytic leukemia (T-PLL). Compared to physiologic CD4+ and CD8+ T-cell subsets, 111 miRNAs were differentially expressed in T-PLL. Of these, 33 belonged to miRNA gene clusters linked to cancer. Genomic variants affecting miRNAs were infrequent with the notable exception of copy number aberrations. Remarkably, we found strong upregulation of the miR-200c/-141 cluster in T-PLL to be associated with DNA hypomethylation and active promoter marks. Our findings suggest that copy number aberrations and epigenetic changes could contribute to miRNA deregulation in T-PLL." @default.
• W4214605016 created "2022-03-02" @default.
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• W4214605016 date "2022-03-29" @default.
• W4214605016 modified "2023-10-15" @default.
• W4214605016 title "T‐cell prolymphocytic leukemia is associated with deregulation of oncogenic <scp>microRNAs</scp> on transcriptional and epigenetic level" @default.
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• W4214605016 doi "https://doi.org/10.1002/gcc.23034" @default.
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