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• W4214606444 startingPage "1077" @default.
• W4214606444 abstract "It is unclear whether the presence of minimal lung function impairment is an independent risk factor for the development of lung cancer in general populations.We conducted a population-based cohort study using nationally representative data from the Korean National Health and Nutrition Examination Survey and the Korean National Health Insurance Service.Of 20,553 participants, 169 were diagnosed with lung cancer during follow-up (median, 6.5 years). Participants with obstructive lung function impairment had increased risk of lung cancer (aHR: 2.51; 95% CI: 1.729-3.629) compared with those with normal lung function. The lower was the quartile or decile of forced expiratory volume in one second (FEV1) or the FEV1/forced vital capacity (FVC) ratio, the significantly higher was the incidence rate of lung cancer (p for trend < 0.0001). With FEV1 values in the lowest quartile (Q4), the incidence of lung cancer was significantly increased regardless of FVC (FEV1 Q4 and FVC values in the higher three quartiles Q1-3: aHR 1.754; 95% CI 1.084-2.847, FEV1 Q4 and FVC Q4: aHR 1.889; 95% CI 1.331-2.681).Our findings suggest that minimal lung function impairment, as expressed by lower FEV1 or FEV1/FVC value, may be associated with increased risk of lung cancer." @default.
• W4214606444 created "2022-03-02" @default.
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• W4214606444 date "2022-02-18" @default.
• W4214606444 modified "2023-09-26" @default.
• W4214606444 title "Impaired Lung Function and Lung Cancer Incidence: A Nationwide Population-Based Cohort Study" @default.
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• W4214606444 doi "https://doi.org/10.3390/jcm11041077" @default.
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