FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4214616612> ?p ?o ?g. }

• W4214616612 endingPage "76" @default.
• W4214616612 startingPage "47" @default.
• W4214616612 abstract "Atherosclerotic cardiovascular disease (ASCVD) stands amongst the leading causes of mortality worldwide and has attracted the attention of world's leading pharmaceutical companies in order to tackle such mortalities. The low-density lipoprotein-cholesterol (LDL-C) is considered the most prominent biomarker for the assessment of ASCVD risk. Distinct inhibitors of 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMG-R), the chief hepatic cholesterogenic enzyme, are being used since last seven decades to manage hypercholesterolemia. On the other hand, discovery and the association of proprotein convertase subtilisin/kexin type-9 (PCSK-9) with increased ASCVD risk have established PCSK-9 as a novel therapeutic target in cardiovascular medicine. PCSK-9 is well reckoned to facilitate the LDL-receptor (LDL-R) degradation and compromised LDL-C clearance leading to the arterial atherosclerotic plaque formation. The currently available HMG-R inhibitors (statins) and PCSK-9 inhibitors (siRNA, anti-sense oligonucleotides, and monoclonal antibodies) have shown great promises in achieving LDL-C lowering goals, however, their life long prescriptions have raised significant concerns. These deficits associated with the synthetic HMG-R and PCSK-9 inhibitors called for the discovery of alternative therapeutic candidates with potential dual HMG-R and PCSK-9 inhibitory activities from natural origins. Therefore, this report firstly describes the mechanistic insights into the cholesterol homeostasis through HMG-R, PCSK-9, and LDL-R functionality and then compiles the pharmacological effects of natural secondary metabolites with special emphasis on their dual HMG-R and PCSK-9 inhibitory action. In conclusion, various natural products exhibit atheroprotective effects via targeting HMG-R and PCSK-9 activities and lipoprotein metabolism, however, further clinical assessments are still warranted prior their approval for ASCVD risk management in hypercholesterolemic patients." @default.
• W4214616612 created "2022-03-02" @default.
• W4214616612 creator A5033431592 @default.
• W4214616612 creator A5042185432 @default.
• W4214616612 creator A5073913285 @default.
• W4214616612 date "2022-01-01" @default.
• W4214616612 modified "2023-09-28" @default.
• W4214616612 title "Potential dual inhibitors of PCSK-9 and HMG-R from natural sources in cardiovascular risk management." @default.
• W4214616612 cites W1233848276 @default.
• W4214616612 cites W1235280006 @default.
• W4214616612 cites W1485528518 @default.
• W4214616612 cites W1489741616 @default.
• W4214616612 cites W1506805851 @default.
• W4214616612 cites W1585832101 @default.
• W4214616612 cites W1791438915 @default.
• W4214616612 cites W1852913314 @default.
• W4214616612 cites W1919798475 @default.
• W4214616612 cites W1953048298 @default.
• W4214616612 cites W1957108698 @default.
• W4214616612 cites W1965308849 @default.
• W4214616612 cites W1966653494 @default.
• W4214616612 cites W1969747282 @default.
• W4214616612 cites W1971705763 @default.
• W4214616612 cites W1972709924 @default.
• W4214616612 cites W1976194786 @default.
• W4214616612 cites W1976691226 @default.
• W4214616612 cites W1977777929 @default.
• W4214616612 cites W1979501382 @default.
• W4214616612 cites W1984985876 @default.
• W4214616612 cites W1987486422 @default.
• W4214616612 cites W1988271836 @default.
• W4214616612 cites W1988805720 @default.
• W4214616612 cites W1992731699 @default.
• W4214616612 cites W1995896589 @default.
• W4214616612 cites W1999897292 @default.
• W4214616612 cites W2000327944 @default.
• W4214616612 cites W2002602716 @default.
• W4214616612 cites W2003405740 @default.
• W4214616612 cites W2005966152 @default.
• W4214616612 cites W2006572302 @default.
• W4214616612 cites W2011113610 @default.
• W4214616612 cites W2011857098 @default.
• W4214616612 cites W2013847320 @default.
• W4214616612 cites W2016397148 @default.
• W4214616612 cites W2018740887 @default.
• W4214616612 cites W2019222155 @default.
• W4214616612 cites W2020253830 @default.
• W4214616612 cites W2022864291 @default.
• W4214616612 cites W2024552609 @default.
• W4214616612 cites W2027167684 @default.
• W4214616612 cites W2028743301 @default.
• W4214616612 cites W2034134526 @default.
• W4214616612 cites W2036218630 @default.
• W4214616612 cites W2036240047 @default.
• W4214616612 cites W2036283295 @default.
• W4214616612 cites W2036304437 @default.
• W4214616612 cites W2036779682 @default.
• W4214616612 cites W2036845233 @default.
• W4214616612 cites W2038053883 @default.
• W4214616612 cites W2040612932 @default.
• W4214616612 cites W2040930316 @default.
• W4214616612 cites W2043461445 @default.
• W4214616612 cites W2044940018 @default.
• W4214616612 cites W2050831937 @default.
• W4214616612 cites W2054610237 @default.
• W4214616612 cites W2055317640 @default.
• W4214616612 cites W2056805087 @default.
• W4214616612 cites W2062930966 @default.
• W4214616612 cites W2064877960 @default.
• W4214616612 cites W2065425798 @default.
• W4214616612 cites W2075284190 @default.
• W4214616612 cites W2075365571 @default.
• W4214616612 cites W2078320449 @default.
• W4214616612 cites W2079613002 @default.
• W4214616612 cites W2079628186 @default.
• W4214616612 cites W2082054121 @default.
• W4214616612 cites W2085938451 @default.
• W4214616612 cites W2090067784 @default.
• W4214616612 cites W2094222285 @default.
• W4214616612 cites W2094567706 @default.
• W4214616612 cites W2096102424 @default.
• W4214616612 cites W2098251276 @default.
• W4214616612 cites W2099654648 @default.
• W4214616612 cites W2099784932 @default.
• W4214616612 cites W2102097628 @default.
• W4214616612 cites W2106240274 @default.
• W4214616612 cites W2107841008 @default.
• W4214616612 cites W2110083155 @default.
• W4214616612 cites W2112623775 @default.
• W4214616612 cites W2116971716 @default.
• W4214616612 cites W2119708151 @default.
• W4214616612 cites W2120181084 @default.
• W4214616612 cites W2120866695 @default.
• W4214616612 cites W2121020498 @default.
• W4214616612 cites W2126229169 @default.
• W4214616612 cites W2129582474 @default.
• W4214616612 cites W2130060675 @default.
• W4214616612 cites W2130986416 @default.

• next