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- W4214621974 abstract "This chapter discusses the microvascular patency in ischemia and reperfusion. A direct experimental approach to detect the existence of nonperfused capillaries is the intravenous injection of an intravascular perfusion marker and the analysis of the brain tissue taken after different circulation times of a few seconds to several minutes. If nonperfused capillaries exist in the brain, which open up from time to time, only a fraction of the existing capillaries show up as being perfused at circulation times of a few seconds. The theories of capillary cycling and of a recruitment of nonperfused capillaries and the experiments showing that these theories have to be refuted have been based on a kind of all-or-none approach: either capillaries are perfused or they are not perfused. This approach, although difficult enough in its experimental verification, is only a first step in the understanding of the dynamics of microvascular perfusion. The distribution of capillary flow can be verified from the amount of intravascular marker contained in the different capillaries 3 to 4 s after an intravenous bolus injection of the intravascular marker Evans blue. During forebrain ischemia, cerebral blood flow is drastically decreased in the forebrain; however, all capillaries remain perfused, although at a lowered velocity. During reperfusion, occasional perfusion deficits show up." @default.
- W4214621974 created "2022-03-02" @default.
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- W4214621974 date "1997-01-01" @default.
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- W4214621974 title "Microvascular Patency in Ischemia and Reperfusion" @default.
- W4214621974 doi "https://doi.org/10.1016/b978-012743170-3/50062-5" @default.
- W4214621974 hasPublicationYear "1997" @default.
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