Matches in SemOpenAlex for { <https://semopenalex.org/work/W4214651038> ?p ?o ?g. }
- W4214651038 endingPage "103844" @default.
- W4214651038 startingPage "103844" @default.
- W4214651038 abstract "Operational tolerance is the holy grail in solid organ transplantation. Previous reports showed that the urinary compartment of operationally tolerant recipients harbor a specific and unique profile. We hypothesized that spontaneous tolerant kidney transplanted recipients (KTR) would have a specific urinary metabolomic profile associated to operational tolerance.We performed metabolomic profiling on urine samples from healthy volunteers, stable KTR under standard and minimal immunosuppression and spontaneous tolerant KTR using liquid chromatography in tandem with mass spectrometry. Supervised and unsupervised multivariate computational analyses were used to highlight urinary metabolomic profile and metabolite identification thanks to workflow4metabolomic platform.The urinary metabolome was composed of approximately 2700 metabolites. Raw unsupervised clustering allowed us to separate healthy volunteers and tolerant KTR from others. We confirmed by two methods a specific urinary metabolomic signature in tolerant KTR mainly driven by kynurenic acid independent of immunosuppressive drugs, serum creatinine and gender.Kynurenic acid and tryptamine enrichment allowed the identification of putative pathways and metabolites associated with operational tolerance like IDO, GRP35 and AhR and indole alkaloids.This study was supported by the ANR, IRSRPL and CHU de Nantes." @default.
- W4214651038 created "2022-03-02" @default.
- W4214651038 creator A5039888642 @default.
- W4214651038 creator A5045996056 @default.
- W4214651038 creator A5047490177 @default.
- W4214651038 creator A5052099125 @default.
- W4214651038 creator A5052951076 @default.
- W4214651038 creator A5055192821 @default.
- W4214651038 creator A5065386977 @default.
- W4214651038 creator A5078064171 @default.
- W4214651038 creator A5080143909 @default.
- W4214651038 creator A5089422245 @default.
- W4214651038 date "2022-03-01" @default.
- W4214651038 modified "2023-10-18" @default.
- W4214651038 title "Urinary metabolomic profiling from spontaneous tolerant kidney transplanted recipients shows enrichment in tryptophan-derived metabolites" @default.
- W4214651038 cites W143096088 @default.
- W4214651038 cites W1535455654 @default.
- W4214651038 cites W1575032903 @default.
- W4214651038 cites W1582684391 @default.
- W4214651038 cites W1602285742 @default.
- W4214651038 cites W1964010911 @default.
- W4214651038 cites W1966714493 @default.
- W4214651038 cites W1968430975 @default.
- W4214651038 cites W1976566839 @default.
- W4214651038 cites W1982336014 @default.
- W4214651038 cites W1984584304 @default.
- W4214651038 cites W2006668452 @default.
- W4214651038 cites W2008343182 @default.
- W4214651038 cites W2013683935 @default.
- W4214651038 cites W2016907310 @default.
- W4214651038 cites W2018572283 @default.
- W4214651038 cites W2023535481 @default.
- W4214651038 cites W2035968282 @default.
- W4214651038 cites W2039239630 @default.
- W4214651038 cites W2054310494 @default.
- W4214651038 cites W2073503722 @default.
- W4214651038 cites W2082204867 @default.
- W4214651038 cites W2083931271 @default.
- W4214651038 cites W2089370088 @default.
- W4214651038 cites W2093999858 @default.
- W4214651038 cites W2097615954 @default.
- W4214651038 cites W2103145251 @default.
- W4214651038 cites W2114708984 @default.
- W4214651038 cites W2120171195 @default.
- W4214651038 cites W2136200837 @default.
- W4214651038 cites W2137442990 @default.
- W4214651038 cites W2145249725 @default.
- W4214651038 cites W2147557958 @default.
- W4214651038 cites W2147888063 @default.
- W4214651038 cites W2148001303 @default.
- W4214651038 cites W2149309843 @default.
- W4214651038 cites W2159950489 @default.
- W4214651038 cites W2183734263 @default.
- W4214651038 cites W2298020624 @default.
- W4214651038 cites W2341820027 @default.
- W4214651038 cites W2460856832 @default.
- W4214651038 cites W2555594290 @default.
- W4214651038 cites W2567980763 @default.
- W4214651038 cites W2580225045 @default.
- W4214651038 cites W2582977745 @default.
- W4214651038 cites W2591817769 @default.
- W4214651038 cites W2593533643 @default.
- W4214651038 cites W2613634859 @default.
- W4214651038 cites W2735452220 @default.
- W4214651038 cites W2773128019 @default.
- W4214651038 cites W2783132192 @default.
- W4214651038 cites W2787157979 @default.
- W4214651038 cites W2789740507 @default.
- W4214651038 cites W2799651670 @default.
- W4214651038 cites W2807316315 @default.
- W4214651038 cites W2941550481 @default.
- W4214651038 cites W2945344737 @default.
- W4214651038 cites W2965087799 @default.
- W4214651038 cites W2969552825 @default.
- W4214651038 cites W2987137992 @default.
- W4214651038 cites W2990820419 @default.
- W4214651038 cites W3013317600 @default.
- W4214651038 cites W3013530725 @default.
- W4214651038 cites W3044971709 @default.
- W4214651038 cites W746699443 @default.
- W4214651038 doi "https://doi.org/10.1016/j.ebiom.2022.103844" @default.
- W4214651038 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35241402" @default.
- W4214651038 hasPublicationYear "2022" @default.
- W4214651038 type Work @default.
- W4214651038 citedByCount "4" @default.
- W4214651038 countsByYear W42146510382022 @default.
- W4214651038 countsByYear W42146510382023 @default.
- W4214651038 crossrefType "journal-article" @default.
- W4214651038 hasAuthorship W4214651038A5039888642 @default.
- W4214651038 hasAuthorship W4214651038A5045996056 @default.
- W4214651038 hasAuthorship W4214651038A5047490177 @default.
- W4214651038 hasAuthorship W4214651038A5052099125 @default.
- W4214651038 hasAuthorship W4214651038A5052951076 @default.
- W4214651038 hasAuthorship W4214651038A5055192821 @default.
- W4214651038 hasAuthorship W4214651038A5065386977 @default.
- W4214651038 hasAuthorship W4214651038A5078064171 @default.
- W4214651038 hasAuthorship W4214651038A5080143909 @default.
- W4214651038 hasAuthorship W4214651038A5089422245 @default.