FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4214654623> ?p ?o ?g. }

• W4214654623 endingPage "1164" @default.
• W4214654623 startingPage "1155" @default.
• W4214654623 abstract "Alemtuzumab, a monoclonal antibody that depletes CD52-bearing immune cells, is an effective drug for the treatment of severe or glucocorticoid-resistant acute kidney transplant rejection (AR). Patient-specific predictions on treatment response are, however, urgently needed, given the severe side effects of alemtuzumab. This study developed a multidimensional prediction model with the aim of generating clinically useful prognostic scores for the response to alemtuzumab. Clinical and histological characteristics were collected retrospectively from patients who were treated with alemtuzumab for AR. In addition, targeted gene expression profiling of AR biopsy tissues was performed. Least absolute shrinkage and selection operator (LASSO) logistic regression modeling was used to construct the ALEMtuzumab for Acute Rejection (ALEMAR) prognostic score. Response to alemtuzumab was defined as patient and allograft survival and at least once an estimated glomerular filtration rate (eGFR) > 30 mL/min/1.73 m2 during the first 6 months after treatment. One hundred fifteen patients were included, of which 84 (73%) had a response to alemtuzumab. The ALEMAR-score accurately predicted the chance of response. Gene expression analysis identified 13 differentially expressed genes between responders and nonresponders. The combination of the ALEMAR-score and selected genes resulted in improved predictions of treatment response. The present preliminary prediction model is potentially helpful for the development of stratified alemtuzumab treatment for acute kidney transplant rejection but requires validation." @default.
• W4214654623 created "2022-03-02" @default.
• W4214654623 creator A5003481032 @default.
• W4214654623 creator A5003727702 @default.
• W4214654623 creator A5030166115 @default.
• W4214654623 creator A5035752811 @default.
• W4214654623 creator A5038813258 @default.
• W4214654623 creator A5049316980 @default.
• W4214654623 creator A5071589826 @default.
• W4214654623 creator A5091596437 @default.
• W4214654623 date "2022-03-08" @default.
• W4214654623 modified "2023-09-27" @default.
• W4214654623 title "Clinical and Molecular Profiling to Develop a Potential Prediction Model for the Response to Alemtuzumab Therapy for Acute Kidney Transplant Rejection" @default.
• W4214654623 cites W1664088763 @default.
• W4214654623 cites W1930602146 @default.
• W4214654623 cites W1965018198 @default.
• W4214654623 cites W1977475714 @default.
• W4214654623 cites W1978925768 @default.
• W4214654623 cites W1994682257 @default.
• W4214654623 cites W2000354809 @default.
• W4214654623 cites W2002825563 @default.
• W4214654623 cites W2006632144 @default.
• W4214654623 cites W2010606148 @default.
• W4214654623 cites W2021724645 @default.
• W4214654623 cites W2053797842 @default.
• W4214654623 cites W2068536961 @default.
• W4214654623 cites W2076870975 @default.
• W4214654623 cites W2087764276 @default.
• W4214654623 cites W2088684372 @default.
• W4214654623 cites W2089125929 @default.
• W4214654623 cites W2099801548 @default.
• W4214654623 cites W2109325327 @default.
• W4214654623 cites W2124667190 @default.
• W4214654623 cites W2125959011 @default.
• W4214654623 cites W2127536951 @default.
• W4214654623 cites W2155965977 @default.
• W4214654623 cites W2177266035 @default.
• W4214654623 cites W2323204318 @default.
• W4214654623 cites W2497695869 @default.
• W4214654623 cites W2566626204 @default.
• W4214654623 cites W2588622997 @default.
• W4214654623 cites W2607031541 @default.
• W4214654623 cites W2727082787 @default.
• W4214654623 cites W2735356657 @default.
• W4214654623 cites W2774126255 @default.
• W4214654623 cites W2780003718 @default.
• W4214654623 cites W2803196213 @default.
• W4214654623 cites W2808825376 @default.
• W4214654623 cites W2907106394 @default.
• W4214654623 cites W2913505041 @default.
• W4214654623 cites W2923768067 @default.
• W4214654623 cites W2950972979 @default.
• W4214654623 cites W2951470721 @default.
• W4214654623 cites W2974347135 @default.
• W4214654623 cites W3016450513 @default.
• W4214654623 cites W3016543462 @default.
• W4214654623 cites W3018173909 @default.
• W4214654623 cites W3038616588 @default.
• W4214654623 cites W3045371098 @default.
• W4214654623 cites W3128582350 @default.
• W4214654623 cites W3164074759 @default.
• W4214654623 cites W85233391 @default.
• W4214654623 doi "https://doi.org/10.1002/cpt.2566" @default.
• W4214654623 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35202481" @default.
• W4214654623 hasPublicationYear "2022" @default.
• W4214654623 type Work @default.
• W4214654623 citedByCount "2" @default.
• W4214654623 countsByYear W42146546232022 @default.
• W4214654623 crossrefType "journal-article" @default.
• W4214654623 hasAuthorship W4214654623A5003481032 @default.
• W4214654623 hasAuthorship W4214654623A5003727702 @default.
• W4214654623 hasAuthorship W4214654623A5030166115 @default.
• W4214654623 hasAuthorship W4214654623A5035752811 @default.
• W4214654623 hasAuthorship W4214654623A5038813258 @default.
• W4214654623 hasAuthorship W4214654623A5049316980 @default.
• W4214654623 hasAuthorship W4214654623A5071589826 @default.
• W4214654623 hasAuthorship W4214654623A5091596437 @default.
• W4214654623 hasBestOaLocation W42146546231 @default.
• W4214654623 hasConcept C126322002 @default.
• W4214654623 hasConcept C143998085 @default.
• W4214654623 hasConcept C151956035 @default.
• W4214654623 hasConcept C159641895 @default.
• W4214654623 hasConcept C203014093 @default.
• W4214654623 hasConcept C2778384904 @default.
• W4214654623 hasConcept C2779015954 @default.
• W4214654623 hasConcept C2780091579 @default.
• W4214654623 hasConcept C2780303639 @default.
• W4214654623 hasConcept C2911091166 @default.
• W4214654623 hasConcept C71924100 @default.
• W4214654623 hasConceptScore W4214654623C126322002 @default.
• W4214654623 hasConceptScore W4214654623C143998085 @default.
• W4214654623 hasConceptScore W4214654623C151956035 @default.
• W4214654623 hasConceptScore W4214654623C159641895 @default.
• W4214654623 hasConceptScore W4214654623C203014093 @default.
• W4214654623 hasConceptScore W4214654623C2778384904 @default.
• W4214654623 hasConceptScore W4214654623C2779015954 @default.
• W4214654623 hasConceptScore W4214654623C2780091579 @default.
• W4214654623 hasConceptScore W4214654623C2780303639 @default.

• next