FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4214657633> ?p ?o ?g. }

• W4214657633 abstract "Copper modulates secondary metabolism in Streptomyces. Although the cytosolic copper concentration is controlled by several chaperones and transporters, the formation of copper nanoparticles (NPs) and its relation to the antibiotic production has never been established in the model Streptomyces coelicolor. In this work, state-of-the-art analytical tools are used to evaluate the incorporation of copper in individual spores of S. coelicolor at different exposure concentrations (40, 80, and 160 μM Cu). Among them, the use of single cell-inductively coupled plasma-mass spectrometry revealed incorporation levels in the range of 2 to 2.5 fg/spore (median) increasing up to 4.75 fg/spore at the upper exposure concentrations. The copper storage within the spores in the form of NPs was evaluated using a combination of single particle-inductively coupled plasma-mass spectrometry and transmission electron microscopy. The obtained data confirmed the presence of NPs in the range of 8 to 40 (mean size 21 nm) inside S. coelicolor spores. The presence of the NPs was correlated with the actinorhodin production in liquid non-sporulating cultures amended with up to 80 μM Cu. However, further increase to 160 μM Cu, yielded to a significant decrease in antibiotic production. Secondary metabolism is activated under stressful conditions and cytosolic copper seems to be one of the signals triggering antibiotic production. Particularly, NP formation might contribute to modulate the secondary metabolism and prevent for copper toxicity. This work describes, for first time, the formation of endogenous copper NPs in S. coelicolor and reveals their correlation with the secondary metabolism." @default.
• W4214657633 created "2022-03-02" @default.
• W4214657633 creator A5018570875 @default.
• W4214657633 creator A5022961900 @default.
• W4214657633 creator A5024488677 @default.
• W4214657633 creator A5048240570 @default.
• W4214657633 creator A5051793026 @default.
• W4214657633 creator A5055268064 @default.
• W4214657633 date "2022-03-01" @default.
• W4214657633 modified "2023-10-18" @default.
• W4214657633 title "Evaluation of copper uptake in individual spores of <i>Streptomyces coelicolor</i> and endogenic nanoparticles formation to modulate the secondary metabolism" @default.
• W4214657633 cites W1502003406 @default.
• W4214657633 cites W1571701196 @default.
• W4214657633 cites W1873047656 @default.
• W4214657633 cites W1973353568 @default.
• W4214657633 cites W1997549589 @default.
• W4214657633 cites W2035133853 @default.
• W4214657633 cites W2045930424 @default.
• W4214657633 cites W2047976781 @default.
• W4214657633 cites W2064477837 @default.
• W4214657633 cites W2073540735 @default.
• W4214657633 cites W2082717449 @default.
• W4214657633 cites W2142314320 @default.
• W4214657633 cites W2146294514 @default.
• W4214657633 cites W2149424333 @default.
• W4214657633 cites W2151582223 @default.
• W4214657633 cites W2153584471 @default.
• W4214657633 cites W2155967620 @default.
• W4214657633 cites W2555427031 @default.
• W4214657633 cites W2761135422 @default.
• W4214657633 cites W2775605161 @default.
• W4214657633 cites W2779959591 @default.
• W4214657633 cites W2792727010 @default.
• W4214657633 cites W2801550441 @default.
• W4214657633 cites W2804141990 @default.
• W4214657633 cites W2912208153 @default.
• W4214657633 cites W2921238743 @default.
• W4214657633 cites W2925065138 @default.
• W4214657633 cites W2952338578 @default.
• W4214657633 cites W2995792216 @default.
• W4214657633 cites W3041150331 @default.
• W4214657633 cites W3199555026 @default.
• W4214657633 cites W4211156923 @default.
• W4214657633 doi "https://doi.org/10.1093/mtomcs/mfac015" @default.
• W4214657633 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35238926" @default.
• W4214657633 hasPublicationYear "2022" @default.
• W4214657633 type Work @default.
• W4214657633 citedByCount "1" @default.
• W4214657633 countsByYear W42146576332022 @default.
• W4214657633 crossrefType "journal-article" @default.
• W4214657633 hasAuthorship W4214657633A5018570875 @default.
• W4214657633 hasAuthorship W4214657633A5022961900 @default.
• W4214657633 hasAuthorship W4214657633A5024488677 @default.
• W4214657633 hasAuthorship W4214657633A5048240570 @default.
• W4214657633 hasAuthorship W4214657633A5051793026 @default.
• W4214657633 hasAuthorship W4214657633A5055268064 @default.
• W4214657633 hasConcept C104317684 @default.
• W4214657633 hasConcept C12554922 @default.
• W4214657633 hasConcept C143065580 @default.
• W4214657633 hasConcept C155672457 @default.
• W4214657633 hasConcept C162356407 @default.
• W4214657633 hasConcept C165697059 @default.
• W4214657633 hasConcept C171250308 @default.
• W4214657633 hasConcept C174618031 @default.
• W4214657633 hasConcept C178790620 @default.
• W4214657633 hasConcept C181199279 @default.
• W4214657633 hasConcept C185592680 @default.
• W4214657633 hasConcept C192562407 @default.
• W4214657633 hasConcept C2777157883 @default.
• W4214657633 hasConcept C2778404011 @default.
• W4214657633 hasConcept C2780681812 @default.
• W4214657633 hasConcept C43617362 @default.
• W4214657633 hasConcept C544778455 @default.
• W4214657633 hasConcept C553450214 @default.
• W4214657633 hasConcept C55493867 @default.
• W4214657633 hasConcept C57409179 @default.
• W4214657633 hasConcept C62231903 @default.
• W4214657633 hasConcept C86803240 @default.
• W4214657633 hasConcept C89423630 @default.
• W4214657633 hasConceptScore W4214657633C104317684 @default.
• W4214657633 hasConceptScore W4214657633C12554922 @default.
• W4214657633 hasConceptScore W4214657633C143065580 @default.
• W4214657633 hasConceptScore W4214657633C155672457 @default.
• W4214657633 hasConceptScore W4214657633C162356407 @default.
• W4214657633 hasConceptScore W4214657633C165697059 @default.
• W4214657633 hasConceptScore W4214657633C171250308 @default.
• W4214657633 hasConceptScore W4214657633C174618031 @default.
• W4214657633 hasConceptScore W4214657633C178790620 @default.
• W4214657633 hasConceptScore W4214657633C181199279 @default.
• W4214657633 hasConceptScore W4214657633C185592680 @default.
• W4214657633 hasConceptScore W4214657633C192562407 @default.
• W4214657633 hasConceptScore W4214657633C2777157883 @default.
• W4214657633 hasConceptScore W4214657633C2778404011 @default.
• W4214657633 hasConceptScore W4214657633C2780681812 @default.
• W4214657633 hasConceptScore W4214657633C43617362 @default.
• W4214657633 hasConceptScore W4214657633C544778455 @default.
• W4214657633 hasConceptScore W4214657633C553450214 @default.
• W4214657633 hasConceptScore W4214657633C55493867 @default.
• W4214657633 hasConceptScore W4214657633C57409179 @default.
• W4214657633 hasConceptScore W4214657633C62231903 @default.

• next