FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4214671646> ?p ?o ?g. }

• W4214671646 endingPage "2516" @default.
• W4214671646 startingPage "2516" @default.
• W4214671646 abstract "Tumor viruses gain control of cellular functions when they infect and transform host cells. Alternative splicing is one of the cellular processes exploited by tumor viruses to benefit viral replication and support oncogenesis. Epstein-Barr virus (EBV) participates in a number of cancers, as reported mostly in nasopharyngeal carcinoma (NPC) and Burkitt lymphoma (BL). Using RT-nested-PCR and Northern blot analysis in NPC and BL cells, here we demonstrate that EBV promotes specific alternative splicing of TSG101 pre-mRNA, which generates the TSG101∆154-1054 variant though the agency of its viral proteins, such as EBNA-1, Zta and Rta. The level of TSG101∆154-1054 is particularly enhanced upon EBV entry into the lytic cycle, increasing protein stability of TSG101 and causing the cumulative synthesis of EBV late lytic proteins, such as VCA and gp350/220. TSG101∆154-1054-mediated production of VCA and gp350/220 is blocked by the overexpression of a translational mutant of TSG101∆154-1054 or by the depletion of full-length TSG101, which is consistent with the known role of the TSG101∆154-1054 protein in stabilizing the TSG101 protein. NPC patients whose tumor tissues express TSG101∆154-1054 have high serum levels of anti-VCA antibodies and high levels of viral DNA in their tumors. Our findings highlight the functional importance of TSG101∆154-1054 in allowing full completion of the EBV lytic cycle to produce viral particles. We propose that targeting EBV-induced TSG101 alternative splicing has broad potential as a therapeutic to treat EBV-associated malignancies." @default.
• W4214671646 created "2022-03-02" @default.
• W4214671646 creator A5039388027 @default.
• W4214671646 creator A5050753087 @default.
• W4214671646 creator A5053357007 @default.
• W4214671646 creator A5088193009 @default.
• W4214671646 date "2022-02-24" @default.
• W4214671646 modified "2023-10-05" @default.
• W4214671646 title "Epstein-Barr Virus Enhances Cancer-Specific Aberrant Splicing of TSG101 Pre-mRNA" @default.
• W4214671646 cites W1490865591 @default.
• W4214671646 cites W1576095764 @default.
• W4214671646 cites W1685741210 @default.
• W4214671646 cites W1813266103 @default.
• W4214671646 cites W1876148145 @default.
• W4214671646 cites W1972026365 @default.
• W4214671646 cites W1977297505 @default.
• W4214671646 cites W1988419855 @default.
• W4214671646 cites W1994477430 @default.
• W4214671646 cites W1996835624 @default.
• W4214671646 cites W1997868773 @default.
• W4214671646 cites W1998932993 @default.
• W4214671646 cites W2004007812 @default.
• W4214671646 cites W2013835447 @default.
• W4214671646 cites W2019355571 @default.
• W4214671646 cites W2020054696 @default.
• W4214671646 cites W2021740521 @default.
• W4214671646 cites W2026902839 @default.
• W4214671646 cites W2039974624 @default.
• W4214671646 cites W2051131460 @default.
• W4214671646 cites W2053622680 @default.
• W4214671646 cites W2054971075 @default.
• W4214671646 cites W2055592432 @default.
• W4214671646 cites W2066214482 @default.
• W4214671646 cites W2088786304 @default.
• W4214671646 cites W2090272598 @default.
• W4214671646 cites W2090763433 @default.
• W4214671646 cites W2095024877 @default.
• W4214671646 cites W2101035002 @default.
• W4214671646 cites W2102891026 @default.
• W4214671646 cites W2108131452 @default.
• W4214671646 cites W2110609296 @default.
• W4214671646 cites W2110958455 @default.
• W4214671646 cites W2119642082 @default.
• W4214671646 cites W2122883736 @default.
• W4214671646 cites W2124485816 @default.
• W4214671646 cites W2127362401 @default.
• W4214671646 cites W2128536543 @default.
• W4214671646 cites W2130227077 @default.
• W4214671646 cites W2130448025 @default.
• W4214671646 cites W2136080892 @default.
• W4214671646 cites W2141444757 @default.
• W4214671646 cites W2147198871 @default.
• W4214671646 cites W2164593562 @default.
• W4214671646 cites W2170800093 @default.
• W4214671646 cites W2229954731 @default.
• W4214671646 cites W2278547920 @default.
• W4214671646 cites W2324224266 @default.
• W4214671646 cites W2327027083 @default.
• W4214671646 cites W2534760591 @default.
• W4214671646 cites W2912233401 @default.
• W4214671646 cites W2928101672 @default.
• W4214671646 cites W3010085537 @default.
• W4214671646 cites W3086537988 @default.
• W4214671646 cites W3104145505 @default.
• W4214671646 cites W3123250852 @default.
• W4214671646 cites W3153784747 @default.
• W4214671646 cites W3160440547 @default.
• W4214671646 cites W3168984920 @default.
• W4214671646 doi "https://doi.org/10.3390/ijms23052516" @default.
• W4214671646 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35269659" @default.
• W4214671646 hasPublicationYear "2022" @default.
• W4214671646 type Work @default.
• W4214671646 citedByCount "2" @default.
• W4214671646 countsByYear W42146716462023 @default.
• W4214671646 crossrefType "journal-article" @default.
• W4214671646 hasAuthorship W4214671646A5039388027 @default.
• W4214671646 hasAuthorship W4214671646A5050753087 @default.
• W4214671646 hasAuthorship W4214671646A5053357007 @default.
• W4214671646 hasAuthorship W4214671646A5088193009 @default.
• W4214671646 hasBestOaLocation W42146716461 @default.
• W4214671646 hasConcept C102906071 @default.
• W4214671646 hasConcept C104317684 @default.
• W4214671646 hasConcept C121608353 @default.
• W4214671646 hasConcept C141231307 @default.
• W4214671646 hasConcept C145059251 @default.
• W4214671646 hasConcept C159047783 @default.
• W4214671646 hasConcept C182615771 @default.
• W4214671646 hasConcept C20518536 @default.
• W4214671646 hasConcept C2522874641 @default.
• W4214671646 hasConcept C2778283623 @default.
• W4214671646 hasConcept C502942594 @default.
• W4214671646 hasConcept C54355233 @default.
• W4214671646 hasConcept C54458228 @default.
• W4214671646 hasConcept C555283112 @default.
• W4214671646 hasConcept C67705224 @default.
• W4214671646 hasConcept C86803240 @default.
• W4214671646 hasConceptScore W4214671646C102906071 @default.
• W4214671646 hasConceptScore W4214671646C104317684 @default.

• next