Matches in SemOpenAlex for { <https://semopenalex.org/work/W4214673657> ?p ?o ?g. }
- W4214673657 abstract "Diabetic nephropathy (DN) is one of the main causes of end-stage renal disease (ESRD). Existing treatments cannot control the progression of diabetic nephropathy very well. In diabetic nephropathy, Many monocytes and macrophages infiltrate kidney tissue. However, the role of these cells in the pathogenesis of diabetic nephropathy has not been fully elucidated. In this study, we analyzed patient kidney biopsy specimens, diabetic nephropathy model animals. Meanwhile, we cocultured cells and found that in diabetic nephropathy, damaged intrinsic renal cells (glomerular mesangial cells and renal tubular epithelial cells) recruited monocytes/macrophages to the area of tissue damage to defend against and clear cell damage. This process often involved the activation of different types of macrophages. Interestingly, the infiltrating macrophages were mainly M1 (CD68+iNOS+) macrophages. In diabetic nephropathy, crosstalk between the Notch pathway and NF-κB signaling in macrophages contributed to the polarization of macrophages. Hyperpolarized macrophages secreted large amounts of inflammatory cytokines and exacerbated the inflammatory response, extracellular matrix secretion, fibrosis, and necroptosis of intrinsic kidney cells. Additionally, macrophage depletion therapy with clodronate liposomes and inhibition of the Notch pathway in macrophages alleviated the pathological changes in kidney cells. This study provides new information regarding diabetic nephropathy-related renal inflammation, the causes of macrophage polarization, and therapeutic targets for diabetic nephropathy." @default.
- W4214673657 created "2022-03-02" @default.
- W4214673657 creator A5002169212 @default.
- W4214673657 creator A5016673493 @default.
- W4214673657 creator A5022526821 @default.
- W4214673657 creator A5023103908 @default.
- W4214673657 creator A5023848989 @default.
- W4214673657 creator A5030849116 @default.
- W4214673657 creator A5031578342 @default.
- W4214673657 creator A5049154686 @default.
- W4214673657 creator A5057349004 @default.
- W4214673657 creator A5062770849 @default.
- W4214673657 creator A5077157954 @default.
- W4214673657 creator A5090650583 @default.
- W4214673657 date "2022-02-25" @default.
- W4214673657 modified "2023-10-18" @default.
- W4214673657 title "Excessive Activation of Notch Signaling in Macrophages Promote Kidney Inflammation, Fibrosis, and Necroptosis" @default.
- W4214673657 cites W1508615665 @default.
- W4214673657 cites W1965227048 @default.
- W4214673657 cites W1965987169 @default.
- W4214673657 cites W1981774142 @default.
- W4214673657 cites W1984285951 @default.
- W4214673657 cites W1985231277 @default.
- W4214673657 cites W1991997670 @default.
- W4214673657 cites W1994530298 @default.
- W4214673657 cites W1999729259 @default.
- W4214673657 cites W2001717792 @default.
- W4214673657 cites W2005343249 @default.
- W4214673657 cites W2005928313 @default.
- W4214673657 cites W2007904774 @default.
- W4214673657 cites W2014763555 @default.
- W4214673657 cites W2023122823 @default.
- W4214673657 cites W2029870685 @default.
- W4214673657 cites W2035838779 @default.
- W4214673657 cites W2037466124 @default.
- W4214673657 cites W2039714220 @default.
- W4214673657 cites W2043873569 @default.
- W4214673657 cites W2046021057 @default.
- W4214673657 cites W2051772841 @default.
- W4214673657 cites W2065210647 @default.
- W4214673657 cites W2068828714 @default.
- W4214673657 cites W2070855360 @default.
- W4214673657 cites W2076321944 @default.
- W4214673657 cites W2076990941 @default.
- W4214673657 cites W2091263717 @default.
- W4214673657 cites W2095400574 @default.
- W4214673657 cites W2103412440 @default.
- W4214673657 cites W2117634556 @default.
- W4214673657 cites W2126106255 @default.
- W4214673657 cites W2145434871 @default.
- W4214673657 cites W2145639699 @default.
- W4214673657 cites W2152429535 @default.
- W4214673657 cites W2159662576 @default.
- W4214673657 cites W2230956746 @default.
- W4214673657 cites W2260963185 @default.
- W4214673657 cites W2402060186 @default.
- W4214673657 cites W2418107622 @default.
- W4214673657 cites W2467662596 @default.
- W4214673657 cites W2468375317 @default.
- W4214673657 cites W2525468862 @default.
- W4214673657 cites W2589392019 @default.
- W4214673657 cites W2611397450 @default.
- W4214673657 cites W2744829308 @default.
- W4214673657 cites W2756998230 @default.
- W4214673657 cites W2768079580 @default.
- W4214673657 cites W2770262779 @default.
- W4214673657 cites W2774743973 @default.
- W4214673657 cites W2888953943 @default.
- W4214673657 cites W2894299041 @default.
- W4214673657 cites W2913590717 @default.
- W4214673657 cites W2946524368 @default.
- W4214673657 cites W2954850953 @default.
- W4214673657 cites W2991704370 @default.
- W4214673657 cites W2997673391 @default.
- W4214673657 cites W3024085885 @default.
- W4214673657 cites W3024968315 @default.
- W4214673657 cites W3087790767 @default.
- W4214673657 cites W3132853059 @default.
- W4214673657 cites W4213245349 @default.
- W4214673657 cites W4242587027 @default.
- W4214673657 doi "https://doi.org/10.3389/fimmu.2022.835879" @default.
- W4214673657 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35280997" @default.
- W4214673657 hasPublicationYear "2022" @default.
- W4214673657 type Work @default.
- W4214673657 citedByCount "22" @default.
- W4214673657 countsByYear W42146736572022 @default.
- W4214673657 countsByYear W42146736572023 @default.
- W4214673657 crossrefType "journal-article" @default.
- W4214673657 hasAuthorship W4214673657A5002169212 @default.
- W4214673657 hasAuthorship W4214673657A5016673493 @default.
- W4214673657 hasAuthorship W4214673657A5022526821 @default.
- W4214673657 hasAuthorship W4214673657A5023103908 @default.
- W4214673657 hasAuthorship W4214673657A5023848989 @default.
- W4214673657 hasAuthorship W4214673657A5030849116 @default.
- W4214673657 hasAuthorship W4214673657A5031578342 @default.
- W4214673657 hasAuthorship W4214673657A5049154686 @default.
- W4214673657 hasAuthorship W4214673657A5057349004 @default.
- W4214673657 hasAuthorship W4214673657A5062770849 @default.
- W4214673657 hasAuthorship W4214673657A5077157954 @default.
- W4214673657 hasAuthorship W4214673657A5090650583 @default.