Matches in SemOpenAlex for { <https://semopenalex.org/work/W4214680421> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W4214680421 endingPage "39" @default.
- W4214680421 startingPage "32" @default.
- W4214680421 abstract "Background: Epilepsy is a constant neurological disorder influencing around 50 million individuals globally. However, most epileptic patients do not react to accessible medications and clinical treatments. This research work has been planned to produce novel 1,5-benzodiazepines from chalcone intermediates by ultrasonic irradiation method and perform the anticonvulsant activity by pentylenetetrazole incited seizures tests. Method: Chalcones are used as precursors for synthesizing 1, 5-benzodiazepines by a reaction with ophenylenediamine in absolute ethanol in the presence of glacial acetic acid as a catalyst. The proposed synthesized structures were characterized by melting point, TLC, FTIR, 1H & 13CNMR, and mass spectroscopy. All the molecules were assessed for anticonvulsant activity. Result: Anticonvulsant activity uncovered the fact that the mixes derived from dimethylamino, dimethoxy, hydroxy-substituted chalcones in the 1, 5-benzodiazepines can be used for seizures in mice. These pharmacological examinations have shown that these new subsidiaries can repress seizures incited by pentylenetetrazole in mice proficiently. Our molecular docking studies also supported probable effects. Conclusion: The results are promising, which on further assessments may provoke medicine particles against seizures in mice." @default.
- W4214680421 created "2022-03-02" @default.
- W4214680421 creator A5000765396 @default.
- W4214680421 creator A5015397635 @default.
- W4214680421 creator A5056837157 @default.
- W4214680421 date "2022-03-01" @default.
- W4214680421 modified "2023-10-14" @default.
- W4214680421 title "Ultrasonic Assisted Synthesis, Biological Evaluation, and Molecular Docking of Chalcone-based 1,5-benzodiazepine as Potential Anticonvulsant Agents" @default.
- W4214680421 cites W1516151893 @default.
- W4214680421 cites W1532788029 @default.
- W4214680421 cites W1964004644 @default.
- W4214680421 cites W1966406246 @default.
- W4214680421 cites W1980320018 @default.
- W4214680421 cites W1982371070 @default.
- W4214680421 cites W1988767853 @default.
- W4214680421 cites W2014858249 @default.
- W4214680421 cites W2042986088 @default.
- W4214680421 cites W2043668344 @default.
- W4214680421 cites W2052600692 @default.
- W4214680421 cites W2056927905 @default.
- W4214680421 cites W2059532469 @default.
- W4214680421 cites W2069444350 @default.
- W4214680421 cites W2109152065 @default.
- W4214680421 cites W2137976898 @default.
- W4214680421 cites W2151697120 @default.
- W4214680421 cites W2556543856 @default.
- W4214680421 cites W2556974535 @default.
- W4214680421 cites W2791736908 @default.
- W4214680421 cites W2804322560 @default.
- W4214680421 cites W2902225381 @default.
- W4214680421 cites W2909406575 @default.
- W4214680421 cites W2994873733 @default.
- W4214680421 cites W3003371107 @default.
- W4214680421 cites W3021945460 @default.
- W4214680421 cites W3085079004 @default.
- W4214680421 doi "https://doi.org/10.2174/1573408018666220224145245" @default.
- W4214680421 hasPublicationYear "2022" @default.
- W4214680421 type Work @default.
- W4214680421 citedByCount "0" @default.
- W4214680421 crossrefType "journal-article" @default.
- W4214680421 hasAuthorship W4214680421A5000765396 @default.
- W4214680421 hasAuthorship W4214680421A5015397635 @default.
- W4214680421 hasAuthorship W4214680421A5056837157 @default.
- W4214680421 hasConcept C118552586 @default.
- W4214680421 hasConcept C185592680 @default.
- W4214680421 hasConcept C21951064 @default.
- W4214680421 hasConcept C2775858608 @default.
- W4214680421 hasConcept C2776175493 @default.
- W4214680421 hasConcept C2778186239 @default.
- W4214680421 hasConcept C2780764945 @default.
- W4214680421 hasConcept C71240020 @default.
- W4214680421 hasConcept C71924100 @default.
- W4214680421 hasConcept C98274493 @default.
- W4214680421 hasConceptScore W4214680421C118552586 @default.
- W4214680421 hasConceptScore W4214680421C185592680 @default.
- W4214680421 hasConceptScore W4214680421C21951064 @default.
- W4214680421 hasConceptScore W4214680421C2775858608 @default.
- W4214680421 hasConceptScore W4214680421C2776175493 @default.
- W4214680421 hasConceptScore W4214680421C2778186239 @default.
- W4214680421 hasConceptScore W4214680421C2780764945 @default.
- W4214680421 hasConceptScore W4214680421C71240020 @default.
- W4214680421 hasConceptScore W4214680421C71924100 @default.
- W4214680421 hasConceptScore W4214680421C98274493 @default.
- W4214680421 hasIssue "1" @default.
- W4214680421 hasLocation W42146804211 @default.
- W4214680421 hasOpenAccess W4214680421 @default.
- W4214680421 hasPrimaryLocation W42146804211 @default.
- W4214680421 hasRelatedWork W157685416 @default.
- W4214680421 hasRelatedWork W2029356020 @default.
- W4214680421 hasRelatedWork W2052686354 @default.
- W4214680421 hasRelatedWork W2058274793 @default.
- W4214680421 hasRelatedWork W2395215145 @default.
- W4214680421 hasRelatedWork W2395293583 @default.
- W4214680421 hasRelatedWork W287767609 @default.
- W4214680421 hasRelatedWork W2921289179 @default.
- W4214680421 hasRelatedWork W3133927813 @default.
- W4214680421 hasRelatedWork W4236001271 @default.
- W4214680421 hasVolume "18" @default.
- W4214680421 isParatext "false" @default.
- W4214680421 isRetracted "false" @default.
- W4214680421 workType "article" @default.