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- W4214685890 abstract "The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transmits information received from extracellular polypeptide signals, through transmembrane receptors, directly to transcription factors that bind target gene promoters in the nucleus. This process provides a mechanism for transcriptional regulation without second messengers. Evolutionarily conserved in eukaryotic organisms from slime molds to humans, JAK-STAT signaling appears to be an early adaptation to facilitate intercellular communication that has coevolved with myriad cellular signaling events. This coevolution has given rise to highly adapted, ligand-specific signaling pathways that control gene expression. In addition, the JAK-STAT signaling pathways are regulated by a vast array of intrinsic and environmental stimuli, which can add plasticity to the response of a cell or tissue. The Connections Map provides a generalized view of this JAK-STAT signaling, with additional Connections Maps highlighting the components that are activated by type I interferons (IFN-α/β), IFN-γ, and interleukins and growth factors that activate STAT3." @default.
- W4214685890 created "2022-03-02" @default.
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- W4214685890 date "2003-08-26" @default.
- W4214685890 modified "2023-09-25" @default.
- W4214685890 title "The JAK-STAT Pathway" @default.
- W4214685890 doi "https://doi.org/10.1126/scisignal.1972003cm11" @default.
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