FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4214687308> ?p ?o ?g. }

• W4214687308 endingPage "e0264548" @default.
• W4214687308 startingPage "e0264548" @default.
• W4214687308 abstract "Accurate assessment and monitoring of the Plasmodium falciparum Kelch 13 (pfk13) gene associated with artemisinin resistance is critical to understand the emergence and spread of drug-resistant parasites in malaria-endemic regions. In this study, we evaluated the genomic profile of the pfk13 gene associated with artemisinin resistance in P. falciparum in Nigerian children by targeted sequencing of the pfk13 gene. Genomic DNA was extracted from 332 dried blood (DBS) spot filter paper samples from three Nigerian States. The pfk13 gene was amplified by nested polymerase chain reaction (PCR), and amplicons were sequenced to detect known and novel polymorphisms across the gene. Consensus sequences of samples were mapped to the reference gene sequence obtained from the National Center for Biotechnology Information (NCBI). Out of the 13 single nucleotide polymorphisms (SNPs) detected in the pfk13 gene, five (F451L, N664I, V487E, V692G and Q661H) have not been reported in other endemic countries to the best of our knowledge. Three of these SNPs (V692G, N664I and Q661H) and a non-novel SNP, C469C, were consistent with late parasitological failure (LPF) in two States (Enugu and Plateau States). There was no validated mutation associated with artemisinin resistance in this study. However, a correlation of our study with in vivo and in vitro phenotypes is needed to establish the functional role of detected mutations as markers of artemisinin resistance in Nigeria. This baseline information will be essential in tracking and monitoring P. falciparum resistance to artemisinin in Nigeria." @default.
• W4214687308 created "2022-03-02" @default.
• W4214687308 creator A5002978479 @default.
• W4214687308 creator A5003481541 @default.
• W4214687308 creator A5005268160 @default.
• W4214687308 creator A5017089002 @default.
• W4214687308 creator A5030505658 @default.
• W4214687308 creator A5038752596 @default.
• W4214687308 creator A5040333999 @default.
• W4214687308 creator A5040416858 @default.
• W4214687308 creator A5041979455 @default.
• W4214687308 creator A5060013215 @default.
• W4214687308 creator A5067034828 @default.
• W4214687308 creator A5078539061 @default.
• W4214687308 creator A5087772806 @default.
• W4214687308 date "2022-02-28" @default.
• W4214687308 modified "2023-10-05" @default.
• W4214687308 title "Molecular profiling of the artemisinin resistance Kelch 13 gene in Plasmodium falciparum from Nigeria" @default.
• W4214687308 cites W1842557358 @default.
• W4214687308 cites W1972177048 @default.
• W4214687308 cites W1993347313 @default.
• W4214687308 cites W2001500896 @default.
• W4214687308 cites W2014186251 @default.
• W4214687308 cites W2040713555 @default.
• W4214687308 cites W2055641730 @default.
• W4214687308 cites W2055730063 @default.
• W4214687308 cites W2089878059 @default.
• W4214687308 cites W2090438527 @default.
• W4214687308 cites W2101842428 @default.
• W4214687308 cites W2119156545 @default.
• W4214687308 cites W2124634096 @default.
• W4214687308 cites W2128880918 @default.
• W4214687308 cites W2154213736 @default.
• W4214687308 cites W2161311583 @default.
• W4214687308 cites W2229864756 @default.
• W4214687308 cites W2397788564 @default.
• W4214687308 cites W2465778340 @default.
• W4214687308 cites W2507516857 @default.
• W4214687308 cites W2557591621 @default.
• W4214687308 cites W2571397745 @default.
• W4214687308 cites W2587549020 @default.
• W4214687308 cites W2608549546 @default.
• W4214687308 cites W2624911654 @default.
• W4214687308 cites W2742731343 @default.
• W4214687308 cites W2805807984 @default.
• W4214687308 cites W2885301399 @default.
• W4214687308 cites W2895693270 @default.
• W4214687308 cites W2912798358 @default.
• W4214687308 cites W2922347673 @default.
• W4214687308 cites W2937475087 @default.
• W4214687308 cites W2947127647 @default.
• W4214687308 cites W2972289672 @default.
• W4214687308 cites W2974494339 @default.
• W4214687308 cites W2981142560 @default.
• W4214687308 cites W2999491246 @default.
• W4214687308 cites W3006913511 @default.
• W4214687308 cites W3013513644 @default.
• W4214687308 cites W3025920658 @default.
• W4214687308 cites W3029748724 @default.
• W4214687308 cites W3046809066 @default.
• W4214687308 cites W3114689018 @default.
• W4214687308 cites W3164768305 @default.
• W4214687308 doi "https://doi.org/10.1371/journal.pone.0264548" @default.
• W4214687308 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35226694" @default.
• W4214687308 hasPublicationYear "2022" @default.
• W4214687308 type Work @default.
• W4214687308 citedByCount "6" @default.
• W4214687308 countsByYear W42146873082022 @default.
• W4214687308 countsByYear W42146873082023 @default.
• W4214687308 crossrefType "journal-article" @default.
• W4214687308 hasAuthorship W4214687308A5002978479 @default.
• W4214687308 hasAuthorship W4214687308A5003481541 @default.
• W4214687308 hasAuthorship W4214687308A5005268160 @default.
• W4214687308 hasAuthorship W4214687308A5017089002 @default.
• W4214687308 hasAuthorship W4214687308A5030505658 @default.
• W4214687308 hasAuthorship W4214687308A5038752596 @default.
• W4214687308 hasAuthorship W4214687308A5040333999 @default.
• W4214687308 hasAuthorship W4214687308A5040416858 @default.
• W4214687308 hasAuthorship W4214687308A5041979455 @default.
• W4214687308 hasAuthorship W4214687308A5060013215 @default.
• W4214687308 hasAuthorship W4214687308A5067034828 @default.
• W4214687308 hasAuthorship W4214687308A5078539061 @default.
• W4214687308 hasAuthorship W4214687308A5087772806 @default.
• W4214687308 hasBestOaLocation W42146873081 @default.
• W4214687308 hasConcept C104317684 @default.
• W4214687308 hasConcept C114851261 @default.
• W4214687308 hasConcept C135763542 @default.
• W4214687308 hasConcept C153209595 @default.
• W4214687308 hasConcept C159047783 @default.
• W4214687308 hasConcept C203014093 @default.
• W4214687308 hasConcept C2776120307 @default.
• W4214687308 hasConcept C2778048844 @default.
• W4214687308 hasConcept C2778371730 @default.
• W4214687308 hasConcept C49105822 @default.
• W4214687308 hasConcept C54355233 @default.
• W4214687308 hasConcept C8185291 @default.
• W4214687308 hasConcept C86803240 @default.
• W4214687308 hasConceptScore W4214687308C104317684 @default.

• next