FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4214718249> ?p ?o ?g. }

• W4214718249 endingPage "411" @default.
• W4214718249 startingPage "400" @default.
• W4214718249 abstract "Doxorubicin (DOXO) is a cytostatic agent used in the chemotherapy protocol of several cancers for more than 40 years, but usage of this drug in cancer treatment has been limited due to severe renal and cardiac tissue toxicities that may result in death in patients. Fluvastatin (FV) is a fully synthetic hydroxymethyl glutaryl coenzyme A (HMG-CoA) reductase inhibitor used as a cholesterol-lowering agent in patients with hypercholesterolemia. Previous studies revealed that FV also exhibits antioxidant, anti-inflammatory, and antitumor activity. Additionally, our previous study indicated that FV exerts a prophylactic effect on DOXO-induced testicular toxicity by preventing lipid peroxidation, supporting the antioxidant system, and regulating the blood-testis barrier-associated genes expression. Herein, we purposed to evaluate the possible therapeutic and the protective effects of FV on the DOXO-induced cardiac and renal toxicitiy model by histochemical, immunohistochemical, biochemical, and real-time polymerase chain reaction (real-time PCR) analyses. Results point out protective use of FV exerts a beneficial effect by repressing lipid peroxidation and by regulating the inducible nitric oxide synthase (iNOS), nitric oxide synthase endothelial (eNOS), nuclear factor kappa-B (NF-κB), and Caspase-3 (Casp3) protein and mRNA expressions, which play an important role in mediating DOXO-induced renal and cardiac toxicity mechanisms. In conclusion, FV may be a candidate agent for the prevention of renal and cardiac toxicities in cancer patients receiving DOXO chemotherapy." @default.
• W4214718249 created "2022-03-02" @default.
• W4214718249 creator A5011221995 @default.
• W4214718249 creator A5018050677 @default.
• W4214718249 creator A5031461736 @default.
• W4214718249 creator A5041527275 @default.
• W4214718249 creator A5055212996 @default.
• W4214718249 creator A5055215386 @default.
• W4214718249 creator A5070472267 @default.
• W4214718249 date "2022-02-24" @default.
• W4214718249 modified "2023-10-12" @default.
• W4214718249 title "Fluvastatin alleviates doxorubicin-induced cardiac and renal toxicity in rats via regulation of oxidative stress, inflammation, and apoptosis associated genes expressions" @default.
• W4214718249 cites W1971644907 @default.
• W4214718249 cites W1973440089 @default.
• W4214718249 cites W2001477445 @default.
• W4214718249 cites W2018526794 @default.
• W4214718249 cites W2030813163 @default.
• W4214718249 cites W2040300832 @default.
• W4214718249 cites W2048466854 @default.
• W4214718249 cites W2058263096 @default.
• W4214718249 cites W2059433774 @default.
• W4214718249 cites W2074006270 @default.
• W4214718249 cites W2081905071 @default.
• W4214718249 cites W2084304742 @default.
• W4214718249 cites W2107875451 @default.
• W4214718249 cites W2111945616 @default.
• W4214718249 cites W2118138409 @default.
• W4214718249 cites W2132424612 @default.
• W4214718249 cites W2132493831 @default.
• W4214718249 cites W2134242032 @default.
• W4214718249 cites W2151682626 @default.
• W4214718249 cites W2210237688 @default.
• W4214718249 cites W2258638262 @default.
• W4214718249 cites W2298070784 @default.
• W4214718249 cites W2327491744 @default.
• W4214718249 cites W2586262281 @default.
• W4214718249 cites W2605840862 @default.
• W4214718249 cites W2766261199 @default.
• W4214718249 cites W2898500311 @default.
• W4214718249 cites W2913049987 @default.
• W4214718249 cites W2914726163 @default.
• W4214718249 cites W2956025622 @default.
• W4214718249 cites W2966320189 @default.
• W4214718249 cites W2981595998 @default.
• W4214718249 cites W2983310990 @default.
• W4214718249 cites W2995655208 @default.
• W4214718249 cites W3018019957 @default.
• W4214718249 cites W3044177990 @default.
• W4214718249 cites W3092506414 @default.
• W4214718249 cites W3112738519 @default.
• W4214718249 cites W3125445003 @default.
• W4214718249 cites W3213782756 @default.
• W4214718249 cites W3216651426 @default.
• W4214718249 cites W4206372730 @default.
• W4214718249 cites W953089013 @default.
• W4214718249 doi "https://doi.org/10.1080/01480545.2022.2043351" @default.
• W4214718249 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35209778" @default.
• W4214718249 hasPublicationYear "2022" @default.
• W4214718249 type Work @default.
• W4214718249 citedByCount "2" @default.
• W4214718249 countsByYear W42147182492022 @default.
• W4214718249 countsByYear W42147182492023 @default.
• W4214718249 crossrefType "journal-article" @default.
• W4214718249 hasAuthorship W4214718249A5011221995 @default.
• W4214718249 hasAuthorship W4214718249A5018050677 @default.
• W4214718249 hasAuthorship W4214718249A5031461736 @default.
• W4214718249 hasAuthorship W4214718249A5041527275 @default.
• W4214718249 hasAuthorship W4214718249A5055212996 @default.
• W4214718249 hasAuthorship W4214718249A5055215386 @default.
• W4214718249 hasAuthorship W4214718249A5070472267 @default.
• W4214718249 hasConcept C126322002 @default.
• W4214718249 hasConcept C134018914 @default.
• W4214718249 hasConcept C2776151105 @default.
• W4214718249 hasConcept C2776694085 @default.
• W4214718249 hasConcept C2776914184 @default.
• W4214718249 hasConcept C2777622882 @default.
• W4214718249 hasConcept C2780829032 @default.
• W4214718249 hasConcept C2781303535 @default.
• W4214718249 hasConcept C29730261 @default.
• W4214718249 hasConcept C519581460 @default.
• W4214718249 hasConcept C71924100 @default.
• W4214718249 hasConcept C98274493 @default.
• W4214718249 hasConceptScore W4214718249C126322002 @default.
• W4214718249 hasConceptScore W4214718249C134018914 @default.
• W4214718249 hasConceptScore W4214718249C2776151105 @default.
• W4214718249 hasConceptScore W4214718249C2776694085 @default.
• W4214718249 hasConceptScore W4214718249C2776914184 @default.
• W4214718249 hasConceptScore W4214718249C2777622882 @default.
• W4214718249 hasConceptScore W4214718249C2780829032 @default.
• W4214718249 hasConceptScore W4214718249C2781303535 @default.
• W4214718249 hasConceptScore W4214718249C29730261 @default.
• W4214718249 hasConceptScore W4214718249C519581460 @default.
• W4214718249 hasConceptScore W4214718249C71924100 @default.
• W4214718249 hasConceptScore W4214718249C98274493 @default.
• W4214718249 hasIssue "2" @default.
• W4214718249 hasLocation W42147182491 @default.
• W4214718249 hasLocation W42147182492 @default.
• W4214718249 hasOpenAccess W4214718249 @default.

• next