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• W4214719782 endingPage "1103" @default.
• W4214719782 startingPage "1103" @default.
• W4214719782 abstract "Thrombotic thrombocytopenic purpura (TTP) is a multiorgan disorder. Organ dysfunction occurs as a consequence of widespread microvascular thrombosis, especially in the heart, brain and kidney, causing transient or partial occlusion of vessels, resulting in organ ischemia. Intensive care unit (ICU) admission varies between 40% and 100% of patients with TTP, either because of severe organ failure or in order to initiate emergency plasma exchange (PEx). Severe neurologic manifestations and cardiac involvement have been associated with higher mortality. Acute kidney injury, although usually less severe than that in hemolytic and uremic syndrome, is common during TTP. Initial management in the ICU should always be considered in TTP patients. The current treatment of TTP in the acute phase is based on urgent PEx, combined with corticosteroid therapy, B-cell-targeted immunotherapy, rituximab and inhibition of the interaction between ultra-large Von Willebrand factor multimers and platelets, using caplacizumab, a monoclonal antibody. ICU management permits close monitoring and the rapid introduction of life-sustaining therapies. This review details the epidemiology of TTP in the ICU, organ failures of critically ill patients with TTP, and the initial management of TTP patients in the ICU." @default.
• W4214719782 created "2022-03-02" @default.
• W4214719782 creator A5031014988 @default.
• W4214719782 creator A5047396339 @default.
• W4214719782 date "2022-02-19" @default.
• W4214719782 modified "2023-10-06" @default.
• W4214719782 title "Severe Thrombotic Thrombocytopenic Purpura (TTP) with Organ Failure in Critically Ill Patients" @default.
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• W4214719782 doi "https://doi.org/10.3390/jcm11041103" @default.
• W4214719782 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35207375" @default.
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