Matches in SemOpenAlex for { <https://semopenalex.org/work/W4214726605> ?p ?o ?g. }
- W4214726605 endingPage "154014" @default.
- W4214726605 startingPage "154014" @default.
- W4214726605 abstract "Silymarin, a blend of flavonolignans isolated from plant Silybum marianum L., has long been used as an herbal medicine. Biogenic routes especially the plant-based synthesis of selenium nanoparticles (SeNPs) is safe, eco-friendly, nontoxic and being considered as one of the best strategies for treatment of cancer.Silymarin-mediated green synthesis of SeNPs and their possibility as an anticancer agent have not been reported to date. Therefore, our present study was aimed to synthesize and characterize the selenium mediated silymarin nanoparticles (Si-SeNPs) from silymarin and investigate their possibility as an anticancer agent.The physicochemical characteristics of Si-SeNPs were analyzed using various analytical techniques, such as HPLC, field emission-transmission electron microscope, energy-dispersive X-ray spectrometer, and thermogravimetric analysis. The underlying molecular mechanism were evaluated using AGS gastric cancer cells.Compared with silymarin, the Si-SeNPs exhibited significantly increased cytotoxic effect of AGS cells without exhibiting toxicity on normal cells. Real time PCR and western blotting analysis indicated that Si-SeNPs induced expression of Bax/Bcl-2, cytochrome c, and cleavage of caspase proteins, which is associated with mitochondria-mediated apoptosis signaling in AGS cells. Moreover, agonist assay using PI3K activator indicated that Si-SeNPs-inhibited PI3K/AKT/mTOR pathways were significantly associated as an autophagy and apoptosis signaling in AGS cells.Our study demonstrated the improved anticancer efficacy of Si-SeNPs- induced apoptosis and autophagy pathways, and therefore recommended Si-SeNPs as a novel anticancer agent after in vivo studies." @default.
- W4214726605 created "2022-03-02" @default.
- W4214726605 creator A5023682328 @default.
- W4214726605 creator A5055626179 @default.
- W4214726605 creator A5067352798 @default.
- W4214726605 creator A5068688729 @default.
- W4214726605 creator A5080758596 @default.
- W4214726605 creator A5082836093 @default.
- W4214726605 creator A5088194942 @default.
- W4214726605 date "2022-05-01" @default.
- W4214726605 modified "2023-10-16" @default.
- W4214726605 title "Biosynthesis and cytotoxic effect of silymarin-functionalized selenium nanoparticles induced autophagy mediated cellular apoptosis via downregulation of PI3K/Akt/mTOR pathway in gastric cancer" @default.
- W4214726605 cites W1969690844 @default.
- W4214726605 cites W1993544397 @default.
- W4214726605 cites W2005517353 @default.
- W4214726605 cites W2008090183 @default.
- W4214726605 cites W2044440155 @default.
- W4214726605 cites W2052117124 @default.
- W4214726605 cites W2059738518 @default.
- W4214726605 cites W2070224555 @default.
- W4214726605 cites W2071917878 @default.
- W4214726605 cites W2074305443 @default.
- W4214726605 cites W2077938783 @default.
- W4214726605 cites W2117890432 @default.
- W4214726605 cites W2130160735 @default.
- W4214726605 cites W2140675108 @default.
- W4214726605 cites W2149792725 @default.
- W4214726605 cites W2167656141 @default.
- W4214726605 cites W2183517002 @default.
- W4214726605 cites W2330192312 @default.
- W4214726605 cites W2551969174 @default.
- W4214726605 cites W2680829527 @default.
- W4214726605 cites W2743461224 @default.
- W4214726605 cites W2746091150 @default.
- W4214726605 cites W2762885063 @default.
- W4214726605 cites W2800444636 @default.
- W4214726605 cites W2883624339 @default.
- W4214726605 cites W2897204809 @default.
- W4214726605 cites W2897537410 @default.
- W4214726605 cites W2953425815 @default.
- W4214726605 cites W2955253758 @default.
- W4214726605 cites W2968462139 @default.
- W4214726605 cites W2979613684 @default.
- W4214726605 cites W2995813307 @default.
- W4214726605 cites W2995859967 @default.
- W4214726605 cites W2996498230 @default.
- W4214726605 cites W3006890695 @default.
- W4214726605 cites W3032714120 @default.
- W4214726605 cites W3093165153 @default.
- W4214726605 cites W3119707626 @default.
- W4214726605 doi "https://doi.org/10.1016/j.phymed.2022.154014" @default.
- W4214726605 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35247670" @default.
- W4214726605 hasPublicationYear "2022" @default.
- W4214726605 type Work @default.
- W4214726605 citedByCount "18" @default.
- W4214726605 countsByYear W42147266052022 @default.
- W4214726605 countsByYear W42147266052023 @default.
- W4214726605 crossrefType "journal-article" @default.
- W4214726605 hasAuthorship W4214726605A5023682328 @default.
- W4214726605 hasAuthorship W4214726605A5055626179 @default.
- W4214726605 hasAuthorship W4214726605A5067352798 @default.
- W4214726605 hasAuthorship W4214726605A5068688729 @default.
- W4214726605 hasAuthorship W4214726605A5080758596 @default.
- W4214726605 hasAuthorship W4214726605A5082836093 @default.
- W4214726605 hasAuthorship W4214726605A5088194942 @default.
- W4214726605 hasConcept C121608353 @default.
- W4214726605 hasConcept C154317977 @default.
- W4214726605 hasConcept C185592680 @default.
- W4214726605 hasConcept C190283241 @default.
- W4214726605 hasConcept C202751555 @default.
- W4214726605 hasConcept C203522944 @default.
- W4214726605 hasConcept C54355233 @default.
- W4214726605 hasConcept C55493867 @default.
- W4214726605 hasConcept C75217442 @default.
- W4214726605 hasConcept C86554907 @default.
- W4214726605 hasConcept C86803240 @default.
- W4214726605 hasConcept C96232424 @default.
- W4214726605 hasConcept C98274493 @default.
- W4214726605 hasConceptScore W4214726605C121608353 @default.
- W4214726605 hasConceptScore W4214726605C154317977 @default.
- W4214726605 hasConceptScore W4214726605C185592680 @default.
- W4214726605 hasConceptScore W4214726605C190283241 @default.
- W4214726605 hasConceptScore W4214726605C202751555 @default.
- W4214726605 hasConceptScore W4214726605C203522944 @default.
- W4214726605 hasConceptScore W4214726605C54355233 @default.
- W4214726605 hasConceptScore W4214726605C55493867 @default.
- W4214726605 hasConceptScore W4214726605C75217442 @default.
- W4214726605 hasConceptScore W4214726605C86554907 @default.
- W4214726605 hasConceptScore W4214726605C86803240 @default.
- W4214726605 hasConceptScore W4214726605C96232424 @default.
- W4214726605 hasConceptScore W4214726605C98274493 @default.
- W4214726605 hasFunder F4320321332 @default.
- W4214726605 hasFunder F4320321408 @default.
- W4214726605 hasFunder F4320322120 @default.
- W4214726605 hasLocation W42147266051 @default.
- W4214726605 hasLocation W42147266052 @default.
- W4214726605 hasOpenAccess W4214726605 @default.
- W4214726605 hasPrimaryLocation W42147266051 @default.