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• W4214738901 abstract "Traditional magnetic relaxation switching (MRS) biosensors suffer from poor sensitivity and unsatisfactory stability. In this study, a polydopamine (PDA) nanoparticles (NPs)-Cu2+ chelate complex mediated signal conversion system and a Cu+-catalyzed click chemistry triggered magnetic signal amplification system were evaluated and dynamically integrated into an MRS biosensor. Owing to abundant functional groups and a large surface area, PDA NPs enabled the absorption of a large amount of Cu2+ ions by chelation. The residual Cu2+ ions can be reduced with sodium ascorbate to Cu+, which could initiate the click reaction between azide-functionalized magnetic NPs (MNPs) and alkyne-functionalized MNPs that resulted in the production of aggregated nanoclusters. The transverse relaxation time (T2) depends on the degree of aggregation of MNPs; T2 is expressed as the magnetic signal readout. In addition, PDA NPs can be easily conjugated with antibodies by mixing, thus providing a straightforward bridge that integrates the immunoassay and magnetic signal readout. Combined with the high capacity of PDA NPs for chelating Cu2+ and high efficiency of click reaction for changing the T2 signals, the PDA-MRS biosensor enables the detection of chlorpyrifos with a limit of detection of 0.084 ng/mL, providing 22-fold enhancement than traditional enzyme-linked immunosorbent assay (1.86 ng/mL). This demonstrates its great potential for the detection of hazardous chemical molecules in a complex sample matrix." @default.
• W4214738901 created "2022-03-02" @default.
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• W4214738901 date "2022-07-01" @default.
• W4214738901 modified "2023-10-14" @default.
• W4214738901 title "Magnetic relaxation switching biosensor via polydopamine nanoparticle mediated click chemistry for detection of chlorpyrifos" @default.
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• W4214738901 doi "https://doi.org/10.1016/j.bios.2022.114127" @default.
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