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• W4214741384 abstract "<sec> <title>BACKGROUND</title> Posttraumatic stress disorder (PTSD) is a debilitating, undertreated condition. The web-based delivery of cognitive behavioral therapy supplemented with mindfulness meditation and yoga is a viable treatment that emphasizes self-directed daily practice. </sec> <sec> <title>OBJECTIVE</title> This study aims to examine the effectiveness of a web-based cognitive behavioral therapy, mindfulness, and yoga (CBT-MY) program designed for daily use. </sec> <sec> <title>METHODS</title> We conducted an 8-week, single-arm, experimental, registered clinical trial on adults reporting PTSD symptoms (n=22; aged 18-35 years). Each participant received web-based CBT-MY content and an hour of web-based counseling each week. Pre-post outcomes included self-reported PTSD symptom severity, depression, anxiety, chronic pain, and mindfulness. Pre-post psychophysiological outcomes included peak pupil dilation (PPD) and heart rate variability (HRV). HRV and PPD were also compared with cross-sectional data from a non-PTSD comparison group without a history of clinical mental health diagnoses and CBT-MY exposure (n=46). </sec> <sec> <title>RESULTS</title> Pre-post intention-to-treat analyses revealed substantial improvements in PTSD severity (<i>d</i>=1.60), depression (<i>d</i>=0.83), anxiety (<i>d</i>=0.99), and mindfulness (<i>d</i>=0.88). Linear multilevel mixed models demonstrated a significant pre-post reduction in PPD (<i>B=</i>−0.06; SE=0.01; <i>P</i>&lt;.001; <i>d</i>=0.90) but no significant pre-post change in HRV (<i>P</i>=.87). Overall, participants spent an average of 11.53 (SD 22.76) min/day on self-directed mindfulness practice. </sec> <sec> <title>CONCLUSIONS</title> Web-based CBT-MY was associated with clinically significant symptom reductions and significant PPD changes, suggesting healthier autonomic functioning. Future randomized controlled trials are needed to further examine the gains apparent in this single-arm study. </sec> <sec> <title>CLINICALTRIAL</title> ClinicalTrials.gov NCT03684473; https://clinicaltrials.gov/ct2/show/NCT03684473 </sec>" @default.
• W4214741384 created "2022-03-02" @default.
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• W4214741384 date "2020-12-13" @default.
• W4214741384 modified "2023-09-25" @default.
• W4214741384 title "A Web-Based Cognitive Behavioral Therapy, Mindfulness Meditation, and Yoga Intervention for Posttraumatic Stress Disorder: Single-Arm Experimental Clinical Trial (Preprint)" @default.
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• W4214741384 doi "https://doi.org/10.2196/preprints.26479" @default.
• W4214741384 hasPublicationYear "2020" @default.
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