Matches in SemOpenAlex for { <https://semopenalex.org/work/W4214754059> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W4214754059 abstract "Abstract Background: Psoriasis patients have obvious lipid metabolism disorders. The hyperlipidemia aggravates the development of psoriasis. In this study, we investigated that under the hyperlipidemia conditions, whether metformin could alleviate psoriasis via a Forkhead box O 3 (FOXO3)-driven pathway, as well as the mechanisms underlying. Methods: Wild type or FOXO3 knockdown HaCat cells were treated with free fatty acids (FFA) for 10 days and then co-treated with metformin for another 4 days. Triglyceride (TG) level, cell viability, proliferation, apoptosis, antioxidant enzymes, ROS levels, as well as the transcription activity of FOXO3 were analyzed. Results: Our data showed that FFA treatment promoted the proliferation and inhibited the apoptosis in HaCat cells. However, metformin could reversed all of these changes. Metformin treatment significantly increased the expressions and the activities of superoxide dismutase (SOD) and catalase (CAT), and reduced the reactive oxygen species (ROS) level, while FFA inhibited the antioxidant enzymes and increased the ROS level in HaCat cells. Metformin significantly promoted the autophagy and increase FOXO3 protein level in the nucleus under hyperlipidemia conditions, which was significantly inhibited by FFA treatment. However, all of the effects from metformin were partially blocked by FOXO3 knockdown. Conclusion: This study demonstrated that under the hyperlipidemia conditions, metformin has significant antiproliferation and proapoptosis effects by reducing ROS level as well as increasing autophagy. Both of these were responsible for the alleviation of psoriasis. All of these effects from metformin were through FOXO3-dependent pathway." @default.
- W4214754059 created "2022-03-02" @default.
- W4214754059 creator A5008579200 @default.
- W4214754059 creator A5024693945 @default.
- W4214754059 creator A5037414724 @default.
- W4214754059 creator A5046732096 @default.
- W4214754059 creator A5056587729 @default.
- W4214754059 creator A5066716873 @default.
- W4214754059 creator A5067636820 @default.
- W4214754059 creator A5070732604 @default.
- W4214754059 creator A5078829072 @default.
- W4214754059 creator A5080292813 @default.
- W4214754059 creator A5087485359 @default.
- W4214754059 creator A5091032982 @default.
- W4214754059 date "2022-02-28" @default.
- W4214754059 modified "2023-10-18" @default.
- W4214754059 title "Metformin prevents the psoriasis under hyperlipidemia via activation of the FOXO3" @default.
- W4214754059 doi "https://doi.org/10.21203/rs.3.rs-1389374/v1" @default.
- W4214754059 hasPublicationYear "2022" @default.
- W4214754059 type Work @default.
- W4214754059 citedByCount "0" @default.
- W4214754059 crossrefType "posted-content" @default.
- W4214754059 hasAuthorship W4214754059A5008579200 @default.
- W4214754059 hasAuthorship W4214754059A5024693945 @default.
- W4214754059 hasAuthorship W4214754059A5037414724 @default.
- W4214754059 hasAuthorship W4214754059A5046732096 @default.
- W4214754059 hasAuthorship W4214754059A5056587729 @default.
- W4214754059 hasAuthorship W4214754059A5066716873 @default.
- W4214754059 hasAuthorship W4214754059A5067636820 @default.
- W4214754059 hasAuthorship W4214754059A5070732604 @default.
- W4214754059 hasAuthorship W4214754059A5078829072 @default.
- W4214754059 hasAuthorship W4214754059A5080292813 @default.
- W4214754059 hasAuthorship W4214754059A5087485359 @default.
- W4214754059 hasAuthorship W4214754059A5091032982 @default.
- W4214754059 hasBestOaLocation W42147540591 @default.
- W4214754059 hasConcept C118995209 @default.
- W4214754059 hasConcept C126322002 @default.
- W4214754059 hasConcept C134018914 @default.
- W4214754059 hasConcept C168003608 @default.
- W4214754059 hasConcept C173396325 @default.
- W4214754059 hasConcept C185592680 @default.
- W4214754059 hasConcept C190283241 @default.
- W4214754059 hasConcept C202751555 @default.
- W4214754059 hasConcept C203014093 @default.
- W4214754059 hasConcept C2775838275 @default.
- W4214754059 hasConcept C2778004101 @default.
- W4214754059 hasConcept C2779091943 @default.
- W4214754059 hasConcept C2779306644 @default.
- W4214754059 hasConcept C2779719074 @default.
- W4214754059 hasConcept C2780323712 @default.
- W4214754059 hasConcept C2780564577 @default.
- W4214754059 hasConcept C48349386 @default.
- W4214754059 hasConcept C55493867 @default.
- W4214754059 hasConcept C555293320 @default.
- W4214754059 hasConcept C71924100 @default.
- W4214754059 hasConcept C75217442 @default.
- W4214754059 hasConcept C98274493 @default.
- W4214754059 hasConceptScore W4214754059C118995209 @default.
- W4214754059 hasConceptScore W4214754059C126322002 @default.
- W4214754059 hasConceptScore W4214754059C134018914 @default.
- W4214754059 hasConceptScore W4214754059C168003608 @default.
- W4214754059 hasConceptScore W4214754059C173396325 @default.
- W4214754059 hasConceptScore W4214754059C185592680 @default.
- W4214754059 hasConceptScore W4214754059C190283241 @default.
- W4214754059 hasConceptScore W4214754059C202751555 @default.
- W4214754059 hasConceptScore W4214754059C203014093 @default.
- W4214754059 hasConceptScore W4214754059C2775838275 @default.
- W4214754059 hasConceptScore W4214754059C2778004101 @default.
- W4214754059 hasConceptScore W4214754059C2779091943 @default.
- W4214754059 hasConceptScore W4214754059C2779306644 @default.
- W4214754059 hasConceptScore W4214754059C2779719074 @default.
- W4214754059 hasConceptScore W4214754059C2780323712 @default.
- W4214754059 hasConceptScore W4214754059C2780564577 @default.
- W4214754059 hasConceptScore W4214754059C48349386 @default.
- W4214754059 hasConceptScore W4214754059C55493867 @default.
- W4214754059 hasConceptScore W4214754059C555293320 @default.
- W4214754059 hasConceptScore W4214754059C71924100 @default.
- W4214754059 hasConceptScore W4214754059C75217442 @default.
- W4214754059 hasConceptScore W4214754059C98274493 @default.
- W4214754059 hasLocation W42147540591 @default.
- W4214754059 hasOpenAccess W4214754059 @default.
- W4214754059 hasPrimaryLocation W42147540591 @default.
- W4214754059 hasRelatedWork W1988357714 @default.
- W4214754059 hasRelatedWork W2005084305 @default.
- W4214754059 hasRelatedWork W2033313326 @default.
- W4214754059 hasRelatedWork W2070732543 @default.
- W4214754059 hasRelatedWork W2072752555 @default.
- W4214754059 hasRelatedWork W2107068945 @default.
- W4214754059 hasRelatedWork W2114615641 @default.
- W4214754059 hasRelatedWork W2744240433 @default.
- W4214754059 hasRelatedWork W4214754059 @default.
- W4214754059 hasRelatedWork W4286449159 @default.
- W4214754059 isParatext "false" @default.
- W4214754059 isRetracted "false" @default.
- W4214754059 workType "article" @default.