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- W4214756443 endingPage "1250" @default.
- W4214756443 startingPage "1250" @default.
- W4214756443 abstract "The extracellular matrix is a structure composed of many molecules, including fibrillar (types I, II, III, V, XI, XXIV, XXVII) and non-fibrillar collagens (mainly basement membrane collagens: types IV, VIII, X), non-collagenous glycoproteins (elastin, laminin, fibronectin, thrombospondin, tenascin, osteopontin, osteonectin, entactin, periostin) embedded in a gel of negatively charged water-retaining glycosaminoglycans (GAGs) such as non-sulfated hyaluronic acid (HA) and sulfated GAGs which are linked to a core protein to form proteoglycans (PGs). This highly dynamic molecular network provides critical biochemical and biomechanical cues that mediate the cell-cell and cell-matrix interactions, influence cell growth, migration and differentiation and serve as a reservoir of cytokines and growth factors' action. The breakdown of normal ECM and its replacement with tumor ECM modulate the tumor microenvironment (TME) composition and is an essential part of tumorigenesis and metastasis, acting as key driver for malignant progression. Abnormal ECM also deregulate behavior of stromal cells as well as facilitating tumor-associated angiogenesis and inflammation. Thus, the tumor matrix modulates each of the classically defined hallmarks of cancer promoting the growth, survival and invasion of the cancer. Moreover, various ECM-derived components modulate the immune response affecting T cells, tumor-associated macrophages (TAM), dendritic cells and cancer-associated fibroblasts (CAF). This review article considers the role that extracellular matrix play in breast cancer. Determining the detailed connections between the ECM and cellular processes has helped to identify novel disease markers and therapeutic targets." @default.
- W4214756443 created "2022-03-02" @default.
- W4214756443 creator A5000306101 @default.
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- W4214756443 creator A5018277490 @default.
- W4214756443 creator A5034896892 @default.
- W4214756443 creator A5076989282 @default.
- W4214756443 date "2022-02-25" @default.
- W4214756443 modified "2023-10-09" @default.
- W4214756443 title "The Role of Extracellular Matrix Proteins in Breast Cancer" @default.
- W4214756443 cites W109799418 @default.
- W4214756443 cites W1167031385 @default.
- W4214756443 cites W1481342123 @default.
- W4214756443 cites W1488814076 @default.
- W4214756443 cites W1513104527 @default.
- W4214756443 cites W1517397264 @default.
- W4214756443 cites W1523365630 @default.
- W4214756443 cites W153641409 @default.
- W4214756443 cites W1549738923 @default.
- W4214756443 cites W1552844509 @default.
- W4214756443 cites W1594566844 @default.
- W4214756443 cites W1600765527 @default.
- W4214756443 cites W1604095214 @default.
- W4214756443 cites W1607596966 @default.
- W4214756443 cites W1608048686 @default.
- W4214756443 cites W161836160 @default.
- W4214756443 cites W1778412215 @default.
- W4214756443 cites W1787080797 @default.
- W4214756443 cites W1813803829 @default.
- W4214756443 cites W1820186662 @default.
- W4214756443 cites W1835542206 @default.
- W4214756443 cites W186245066 @default.
- W4214756443 cites W1868626511 @default.
- W4214756443 cites W1879220818 @default.
- W4214756443 cites W1894435873 @default.
- W4214756443 cites W1924119154 @default.
- W4214756443 cites W1939982746 @default.
- W4214756443 cites W1964235021 @default.
- W4214756443 cites W1965940146 @default.
- W4214756443 cites W1966063402 @default.
- W4214756443 cites W1966498047 @default.
- W4214756443 cites W1967120404 @default.
- W4214756443 cites W1967605282 @default.
- W4214756443 cites W1967794479 @default.
- W4214756443 cites W1967895142 @default.
- W4214756443 cites W1968051889 @default.
- W4214756443 cites W1970069848 @default.
- W4214756443 cites W1970294740 @default.
- W4214756443 cites W1971992633 @default.
- W4214756443 cites W1973291656 @default.
- W4214756443 cites W1973387286 @default.
- W4214756443 cites W1973712471 @default.
- W4214756443 cites W1974140746 @default.
- W4214756443 cites W1974678207 @default.
- W4214756443 cites W1976348790 @default.
- W4214756443 cites W1976464671 @default.
- W4214756443 cites W1976766826 @default.
- W4214756443 cites W1977995106 @default.
- W4214756443 cites W1978414874 @default.
- W4214756443 cites W1978975562 @default.
- W4214756443 cites W1979281206 @default.
- W4214756443 cites W1980018706 @default.
- W4214756443 cites W1980209143 @default.
- W4214756443 cites W1980909734 @default.
- W4214756443 cites W1982066003 @default.
- W4214756443 cites W1982654262 @default.
- W4214756443 cites W1983420243 @default.
- W4214756443 cites W1984677655 @default.
- W4214756443 cites W1989418402 @default.
- W4214756443 cites W1989903747 @default.
- W4214756443 cites W1992203325 @default.
- W4214756443 cites W1993778132 @default.
- W4214756443 cites W1994149090 @default.
- W4214756443 cites W1995004906 @default.
- W4214756443 cites W1996131159 @default.
- W4214756443 cites W1997585674 @default.
- W4214756443 cites W1997716890 @default.
- W4214756443 cites W1999183225 @default.
- W4214756443 cites W2002579474 @default.
- W4214756443 cites W2002750345 @default.
- W4214756443 cites W2002757074 @default.
- W4214756443 cites W2003305541 @default.
- W4214756443 cites W2004630197 @default.
- W4214756443 cites W200485066 @default.
- W4214756443 cites W2005801434 @default.
- W4214756443 cites W2006628284 @default.
- W4214756443 cites W2006831658 @default.
- W4214756443 cites W2008135907 @default.
- W4214756443 cites W2008703159 @default.
- W4214756443 cites W2009523688 @default.
- W4214756443 cites W2010069724 @default.
- W4214756443 cites W2010500685 @default.
- W4214756443 cites W2010501457 @default.
- W4214756443 cites W2010690155 @default.
- W4214756443 cites W2011953153 @default.
- W4214756443 cites W2012162957 @default.
- W4214756443 cites W2013326206 @default.