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- W4214762500 abstract "In the nervous system, cell death is important during development, replacementof mitotic cells, and for remodeling. Cell death in response to traumatic,ischemic, or intrinsic events can lead to loss of normal function in diseases of thenervous system ranging from traumatic brain injury, stroke, neurodegenerativediseases, demyelinating diseases, and cancer. The pathways toward cell death inthe nervous system have been of scientific and medical interest. During devel-opment, there is programmed cell death that follows criteria originally describedby Lockshin and colleagues in insect cells (1) and subsequently extend intounderstanding the development of the mammalian nervous system. Outside ofdevelopment, it is not clear if programmed cell death continues to play a role.Apoptosis and necrosis were originally defined morphologically (2), and sub-sequently, biochemical pathways for apoptosis have been intensively studied anddefined. Activation of caspases is the defining biochemical feature of apoptosis.Apoptosis can occur in the nervous system in restricted settings, but in mostcases, cell death does not conform to the morphologic criteria of apoptosis and iscaspase independent. Autophagy, originally defined as a mechanism to recycleorganelles and proteins, has emerged as a potentially important response todiseases involving misfolded proteins and thus may be important in certainneurodegenerative diseases. Interference with the autophagic process can lead toneurodegenerative phenotypes in mice (3-5)." @default.
- W4214762500 created "2022-03-02" @default.
- W4214762500 creator A5001970748 @default.
- W4214762500 date "2008-09-19" @default.
- W4214762500 modified "2023-09-29" @default.
- W4214762500 title "Cellular Senescence and Its Effects on Carcinogenesis" @default.
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