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- W4214769138 abstract "Abstract Salt taste sensation is multifaceted: NaCl at low or high concentrations is preferably or aversively perceived through distinct pathways. Cl − is thought to participate in taste sensation through an unknown mechanism. Here we describe Cl − ion binding and the response of taste receptor type 1 (T1r), a receptor family composing sweet/umami receptors. The T1r2a/T1r3 heterodimer from the medaka fish, currently the sole T1r amenable to structural analyses, exhibited a specific Cl − binding in the vicinity of the amino-acid-binding site in the ligand-binding domain (LBD) of T1r3, which is likely conserved across species, including human T1r3. The Cl − binding induced a conformational change in T1r2a/T1r3LBD at sub-to low-mM concentrations similar to canonical taste substances. Furthermore, oral Cl − application to mice increased impulse frequencies of taste nerves connected to T1r-expressing taste cells and promoted their behavioral preferences attenuated by a T1r-specific blocker or T1r3 knock-out. These results suggest that the Cl − evokes taste sensations by binding to T1r, thereby serving as another preferred salt taste pathway at a low concentration." @default.
- W4214769138 created "2022-03-02" @default.
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- W4214769138 date "2022-02-24" @default.
- W4214769138 modified "2023-09-23" @default.
- W4214769138 title "Chloride ions evoke taste sensations by binding to the extracellular ligand-binding domain of sweet/umami taste receptors" @default.
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- W4214769138 doi "https://doi.org/10.1101/2022.02.23.481615" @default.
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