Matches in SemOpenAlex for { <https://semopenalex.org/work/W4214774032> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W4214774032 abstract "Abstract Background: Successful pregnancy inevitably depends on the implantation of a competent embryo into a receptive endometrium. Although a remarkable improvement of assisted reproductive technology (ART) has been achieved over the last few decades, there are still a number of infertile women experiencing frequent ART failure after repeated attempts due to many unsolved problems including repeated failure of implantation. Many substances have been suggested to improve the rates of embryo implantation by enhancing the endometrial receptivity for the patients who are suffering from repeated failure of implantation. However, despite these numerous extensive research work, there are currently no effective evidence-based treatments to prevent or cure this condition. Therefore, here we aim to suggest non-invasive intra-uterine administration of embryo-secreted chemokine CXCL12 as an effective therapeutic intervention to solve this problem. Results: We demonstrated that chemokine CXCL12 is derived from pre- and peri-implanting embryos and its interaction with endometrial CXCR4 and CXCR7 enhances endometrial receptivity and significantly promoted endothelial vessel formation and sprouting in vitro . Consistently, intra-uterine CXCL12 administration in vivo , which is a completely non-invasive treatment strategy, improved endometrial receptivity showing increased integrin b3 and its ligand osteopontin, and induced endometrial angiogenesis displaying increased numbers of vessel formation near the lining of endometrial epithelial layer with higher CD31 and CD34 expression. Furthermore, intra-uterine CXCL12 application dramatically promoted the rates of embryo implantation with no morphologically retarded embryos. Conclusions: Our present study provides a novel evidence that improved uterine endometrial receptivity and enhanced angiogenesis induced by embryo-derived chemokine CXCL12 may aid to develop a non-invasive therapeutic strategy for clinical treatment or supplement for the patients with repeated implantation failure with less risk." @default.
- W4214774032 created "2022-03-02" @default.
- W4214774032 creator A5013788963 @default.
- W4214774032 creator A5017879313 @default.
- W4214774032 creator A5027059674 @default.
- W4214774032 creator A5028493964 @default.
- W4214774032 creator A5034429234 @default.
- W4214774032 creator A5058077118 @default.
- W4214774032 creator A5063291122 @default.
- W4214774032 creator A5065605894 @default.
- W4214774032 creator A5081642037 @default.
- W4214774032 creator A5088056187 @default.
- W4214774032 creator A5089385842 @default.
- W4214774032 date "2020-07-28" @default.
- W4214774032 modified "2023-10-16" @default.
- W4214774032 title "Embryo-Derived Chemokine CXCL12 Enhances Pregnancy Outcome via Improvement of Endometrial Receptivity" @default.
- W4214774032 doi "https://doi.org/10.21203/rs.3.rs-41890/v1" @default.
- W4214774032 hasPublicationYear "2020" @default.
- W4214774032 type Work @default.
- W4214774032 citedByCount "0" @default.
- W4214774032 crossrefType "posted-content" @default.
- W4214774032 hasAuthorship W4214774032A5013788963 @default.
- W4214774032 hasAuthorship W4214774032A5017879313 @default.
- W4214774032 hasAuthorship W4214774032A5027059674 @default.
- W4214774032 hasAuthorship W4214774032A5028493964 @default.
- W4214774032 hasAuthorship W4214774032A5034429234 @default.
- W4214774032 hasAuthorship W4214774032A5058077118 @default.
- W4214774032 hasAuthorship W4214774032A5063291122 @default.
- W4214774032 hasAuthorship W4214774032A5065605894 @default.
- W4214774032 hasAuthorship W4214774032A5081642037 @default.
- W4214774032 hasAuthorship W4214774032A5088056187 @default.
- W4214774032 hasAuthorship W4214774032A5089385842 @default.
- W4214774032 hasBestOaLocation W42147740321 @default.
- W4214774032 hasConcept C126322002 @default.
- W4214774032 hasConcept C129470790 @default.
- W4214774032 hasConcept C13373296 @default.
- W4214774032 hasConcept C16685009 @default.
- W4214774032 hasConcept C196843134 @default.
- W4214774032 hasConcept C2776914184 @default.
- W4214774032 hasConcept C2777678268 @default.
- W4214774032 hasConcept C2778316770 @default.
- W4214774032 hasConcept C2779066055 @default.
- W4214774032 hasConcept C2779234561 @default.
- W4214774032 hasConcept C2779742232 @default.
- W4214774032 hasConcept C2780394083 @default.
- W4214774032 hasConcept C54355233 @default.
- W4214774032 hasConcept C71924100 @default.
- W4214774032 hasConcept C86803240 @default.
- W4214774032 hasConcept C95444343 @default.
- W4214774032 hasConceptScore W4214774032C126322002 @default.
- W4214774032 hasConceptScore W4214774032C129470790 @default.
- W4214774032 hasConceptScore W4214774032C13373296 @default.
- W4214774032 hasConceptScore W4214774032C16685009 @default.
- W4214774032 hasConceptScore W4214774032C196843134 @default.
- W4214774032 hasConceptScore W4214774032C2776914184 @default.
- W4214774032 hasConceptScore W4214774032C2777678268 @default.
- W4214774032 hasConceptScore W4214774032C2778316770 @default.
- W4214774032 hasConceptScore W4214774032C2779066055 @default.
- W4214774032 hasConceptScore W4214774032C2779234561 @default.
- W4214774032 hasConceptScore W4214774032C2779742232 @default.
- W4214774032 hasConceptScore W4214774032C2780394083 @default.
- W4214774032 hasConceptScore W4214774032C54355233 @default.
- W4214774032 hasConceptScore W4214774032C71924100 @default.
- W4214774032 hasConceptScore W4214774032C86803240 @default.
- W4214774032 hasConceptScore W4214774032C95444343 @default.
- W4214774032 hasLocation W42147740321 @default.
- W4214774032 hasOpenAccess W4214774032 @default.
- W4214774032 hasPrimaryLocation W42147740321 @default.
- W4214774032 hasRelatedWork W10305841 @default.
- W4214774032 hasRelatedWork W10854839 @default.
- W4214774032 hasRelatedWork W13233895 @default.
- W4214774032 hasRelatedWork W13512916 @default.
- W4214774032 hasRelatedWork W13610484 @default.
- W4214774032 hasRelatedWork W4350955 @default.
- W4214774032 hasRelatedWork W5483793 @default.
- W4214774032 hasRelatedWork W6264972 @default.
- W4214774032 hasRelatedWork W6416368 @default.
- W4214774032 hasRelatedWork W8033007 @default.
- W4214774032 isParatext "false" @default.
- W4214774032 isRetracted "false" @default.
- W4214774032 workType "article" @default.