Matches in SemOpenAlex for { <https://semopenalex.org/work/W4214776080> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W4214776080 endingPage "7" @default.
- W4214776080 startingPage "7" @default.
- W4214776080 abstract "Tumor necrosis factor-α (TNF-α) plays an important role in the pathogenesis of inflammatory diseases. Excessive TNF-α expression induces tristetraprolin (TTP), an RNA-binding protein that regulates mRNA degradation, which in turn downregulates TNF and its downstream genes, thus resulting in anti-inflammatory effects. In order to better understand the TNF-α mediated molecular pathways in inflammatory diseases, embryonic fibroblast (MEF) cell lines derived from TTP-deficient (KO) or wild type (WT) mice were treated with TNF-α and gene expression differences between two cell lines were compared by a microarray essay of 9224 genes. We found that TTP-KO cells had higher expression levels of pro-inflammatory genes than TTP-WT cells, and inflammatory genes were differentially regulated by TNF-α between TTP-KO and TTP-WT cells. Through a study of 2-dimentional gene set matrix analysis, we also found the genes upregulated by TNF-α in TTP KO cells were correlated with the pathologic phenotypes in inflammation, joint, or bone diseases. Our study provided a detailed genetic roadmap for further understanding the regulatory effect of TTP in inflammatory pathways related to human diseases." @default.
- W4214776080 created "2022-03-02" @default.
- W4214776080 date "2007-05-01" @default.
- W4214776080 modified "2023-09-23" @default.
- W4214776080 title "Crane Co, USA" @default.
- W4214776080 doi "https://doi.org/10.1016/s1359-6128(07)70199-4" @default.
- W4214776080 hasPublicationYear "2007" @default.
- W4214776080 type Work @default.
- W4214776080 citedByCount "0" @default.
- W4214776080 crossrefType "journal-article" @default.
- W4214776080 hasConcept C104317684 @default.
- W4214776080 hasConcept C105580179 @default.
- W4214776080 hasConcept C127561419 @default.
- W4214776080 hasConcept C127716648 @default.
- W4214776080 hasConcept C150194340 @default.
- W4214776080 hasConcept C153911025 @default.
- W4214776080 hasConcept C164027704 @default.
- W4214776080 hasConcept C17991360 @default.
- W4214776080 hasConcept C186836561 @default.
- W4214776080 hasConcept C203014093 @default.
- W4214776080 hasConcept C2776914184 @default.
- W4214776080 hasConcept C2780381497 @default.
- W4214776080 hasConcept C2780942790 @default.
- W4214776080 hasConcept C2909367411 @default.
- W4214776080 hasConcept C41282012 @default.
- W4214776080 hasConcept C502942594 @default.
- W4214776080 hasConcept C54355233 @default.
- W4214776080 hasConcept C81885089 @default.
- W4214776080 hasConcept C8415881 @default.
- W4214776080 hasConcept C86803240 @default.
- W4214776080 hasConcept C95444343 @default.
- W4214776080 hasConceptScore W4214776080C104317684 @default.
- W4214776080 hasConceptScore W4214776080C105580179 @default.
- W4214776080 hasConceptScore W4214776080C127561419 @default.
- W4214776080 hasConceptScore W4214776080C127716648 @default.
- W4214776080 hasConceptScore W4214776080C150194340 @default.
- W4214776080 hasConceptScore W4214776080C153911025 @default.
- W4214776080 hasConceptScore W4214776080C164027704 @default.
- W4214776080 hasConceptScore W4214776080C17991360 @default.
- W4214776080 hasConceptScore W4214776080C186836561 @default.
- W4214776080 hasConceptScore W4214776080C203014093 @default.
- W4214776080 hasConceptScore W4214776080C2776914184 @default.
- W4214776080 hasConceptScore W4214776080C2780381497 @default.
- W4214776080 hasConceptScore W4214776080C2780942790 @default.
- W4214776080 hasConceptScore W4214776080C2909367411 @default.
- W4214776080 hasConceptScore W4214776080C41282012 @default.
- W4214776080 hasConceptScore W4214776080C502942594 @default.
- W4214776080 hasConceptScore W4214776080C54355233 @default.
- W4214776080 hasConceptScore W4214776080C81885089 @default.
- W4214776080 hasConceptScore W4214776080C8415881 @default.
- W4214776080 hasConceptScore W4214776080C86803240 @default.
- W4214776080 hasConceptScore W4214776080C95444343 @default.
- W4214776080 hasIssue "5" @default.
- W4214776080 hasLocation W42147760801 @default.
- W4214776080 hasOpenAccess W4214776080 @default.
- W4214776080 hasPrimaryLocation W42147760801 @default.
- W4214776080 hasRelatedWork W1983994322 @default.
- W4214776080 hasRelatedWork W2053053668 @default.
- W4214776080 hasRelatedWork W2114409792 @default.
- W4214776080 hasRelatedWork W2362238002 @default.
- W4214776080 hasRelatedWork W2374855950 @default.
- W4214776080 hasRelatedWork W2415025170 @default.
- W4214776080 hasRelatedWork W2900947575 @default.
- W4214776080 hasRelatedWork W2998765584 @default.
- W4214776080 hasRelatedWork W3028482498 @default.
- W4214776080 hasRelatedWork W74695042 @default.
- W4214776080 hasVolume "2007" @default.
- W4214776080 isParatext "false" @default.
- W4214776080 isRetracted "false" @default.
- W4214776080 workType "article" @default.