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• W4214808144 endingPage "103207" @default.
• W4214808144 startingPage "103207" @default.
• W4214808144 abstract "Over the last few decades, there has been an impressive progress on developing novel drug delivery systems and targeted therapies through the use of Nanotechnology. In particular, lipid-based nanosystems attracted attention due to their interesting biological properties and potential to improve safety, stability and delivery efficiency of susceptible drugs. Despite the technological breakthroughs and multiple advantages related to the lipid-based nanosystems, concerns regarding quality, efficacy, and safety have increased along with the widespread of these drug products. The complex and heterogeneous structure that cannot be fully quantitated, characterized, or described by physicochemical analytical methods, as well as, the nonstandard manufacturing process, makes it very hardly to comply with reproducibility requirements and quality standards in their pharmaceutical development. Therefore, the application of a more holistic approach, such as Quality by Design (QbD), may be an effective way of surpassing technical and quality challenges. QbD is a systematic approach to product development that begins with predefined objectives and emphasizes product and process understanding and process control, based on sound science and quality risk management. In this way, a deeper product and process understanding will be achieved, that will lead to more robust and consistent lipid-based nanosystems. The present work aims to map and provide a basic understanding concerning the current state of implementation of the QbD approach in the pharmaceutical development of lipid-based nanosystems. The survey methodology applied relied on the thorough analysis of the existing literature and databases regarding lipid-based nanosystems already approved by the regulatory authorities. This analysis discloses the most common material attributes, process parameters, quality attributes, and other variables that are critical for the quality, efficacy, and safety of lipid-based nanosystems. It also includes a brief survey of current trends of risk assessment tools, design of experiments (DoE) methodologies, and characterization techniques applied to the development of these products. This higher level of knowledge will have a definite contribution to facilitate pharmaceutical development and the increase of the number of lipid-based nanosystems reaching the market in the future." @default.
• W4214808144 created "2022-03-05" @default.
• W4214808144 creator A5005975846 @default.
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• W4214808144 creator A5064456553 @default.
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• W4214808144 creator A5078391390 @default.
• W4214808144 date "2022-04-01" @default.
• W4214808144 modified "2023-10-18" @default.
• W4214808144 title "A quality by design (QbD) approach in pharmaceutical development of lipid-based nanosystems: A systematic review" @default.
• W4214808144 cites W1004696513 @default.
• W4214808144 cites W1013145399 @default.
• W4214808144 cites W1195955210 @default.
• W4214808144 cites W1539484437 @default.
• W4214808144 cites W1771490914 @default.
• W4214808144 cites W1804724315 @default.
• W4214808144 cites W1915340955 @default.
• W4214808144 cites W1918017297 @default.
• W4214808144 cites W1937457842 @default.
• W4214808144 cites W1966952912 @default.
• W4214808144 cites W1969394176 @default.
• W4214808144 cites W1969626225 @default.
• W4214808144 cites W1972452921 @default.
• W4214808144 cites W1975157785 @default.
• W4214808144 cites W1975845832 @default.
• W4214808144 cites W1976075858 @default.
• W4214808144 cites W1977360324 @default.
• W4214808144 cites W1983439306 @default.
• W4214808144 cites W1987688990 @default.
• W4214808144 cites W1993527690 @default.
• W4214808144 cites W1996415777 @default.
• W4214808144 cites W1997044547 @default.
• W4214808144 cites W1999481657 @default.
• W4214808144 cites W2001730688 @default.
• W4214808144 cites W2002679849 @default.
• W4214808144 cites W2009919363 @default.
• W4214808144 cites W2012066956 @default.
• W4214808144 cites W2012485426 @default.
• W4214808144 cites W2012927871 @default.
• W4214808144 cites W2018211378 @default.
• W4214808144 cites W2019920328 @default.
• W4214808144 cites W2021139753 @default.
• W4214808144 cites W2027889438 @default.
• W4214808144 cites W2032439697 @default.
• W4214808144 cites W2037325342 @default.
• W4214808144 cites W2037749877 @default.
• W4214808144 cites W2038490464 @default.
• W4214808144 cites W2043329014 @default.
• W4214808144 cites W2048948729 @default.
• W4214808144 cites W2054655255 @default.
• W4214808144 cites W2054819537 @default.
• W4214808144 cites W2060758748 @default.
• W4214808144 cites W2062064077 @default.
• W4214808144 cites W2067407703 @default.
• W4214808144 cites W2069444430 @default.
• W4214808144 cites W2072405765 @default.
• W4214808144 cites W2074913968 @default.
• W4214808144 cites W2074968605 @default.
• W4214808144 cites W2077163059 @default.
• W4214808144 cites W2078269854 @default.
• W4214808144 cites W2084956669 @default.
• W4214808144 cites W2085692671 @default.
• W4214808144 cites W2085834057 @default.
• W4214808144 cites W2086438722 @default.
• W4214808144 cites W2095145481 @default.
• W4214808144 cites W2101225733 @default.
• W4214808144 cites W2121963092 @default.
• W4214808144 cites W2126209532 @default.
• W4214808144 cites W2142071841 @default.
• W4214808144 cites W2146162734 @default.
• W4214808144 cites W2147592064 @default.
• W4214808144 cites W2148465626 @default.
• W4214808144 cites W2175673889 @default.
• W4214808144 cites W2195593931 @default.
• W4214808144 cites W2198456947 @default.
• W4214808144 cites W2239727806 @default.
• W4214808144 cites W2260322660 @default.
• W4214808144 cites W2266575795 @default.
• W4214808144 cites W2297311793 @default.
• W4214808144 cites W2316119912 @default.
• W4214808144 cites W2318699384 @default.
• W4214808144 cites W2344128389 @default.
• W4214808144 cites W2388009875 @default.
• W4214808144 cites W2467068458 @default.
• W4214808144 cites W2505418923 @default.
• W4214808144 cites W2512140959 @default.
• W4214808144 cites W2518588461 @default.
• W4214808144 cites W2522509600 @default.
• W4214808144 cites W2531054900 @default.
• W4214808144 cites W2542203961 @default.
• W4214808144 cites W2545282995 @default.
• W4214808144 cites W2560468344 @default.
• W4214808144 cites W2563565179 @default.
• W4214808144 cites W2572223192 @default.
• W4214808144 cites W2579967207 @default.
• W4214808144 cites W2584301648 @default.
• W4214808144 cites W2586380775 @default.
• W4214808144 cites W2586751144 @default.

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