Matches in SemOpenAlex for { <https://semopenalex.org/work/W4214811246> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W4214811246 abstract "Lipids constitute 70% of the myelin sheath, and autoantibodies against lipids may contribute to the demyelination that characterizes multiple sclerosis (MS). We used lipid antigen microarrays and lipid mass spectrometry to identify bona fide lipid targets of the autoimmune response in MS brain, and an animal model of MS to explore the role of the identified lipids in autoimmune demyelination. We found that autoantibodies in MS target a phosphate group in phosphatidylserine and oxidized phosphatidylcholine derivatives. Administration of these lipids ameliorated experimental autoimmune encephalomyelitis by suppressing activation and inducing apoptosis of autoreactive T cells, effects mediated by the lipids' saturated fatty acid side chains. Thus, phospholipids represent a natural anti-inflammatory class of compounds that have potential as therapeutics for MS. PMID: 22674551 Funding information This work was supported by: NIAID NIH HHS, United States Grant ID: T32 AI007290 NIA NIH HHS, United States Grant ID: R01 AG031675" @default.
- W4214811246 created "2022-03-05" @default.
- W4214811246 creator A5005416364 @default.
- W4214811246 date "2012-06-14" @default.
- W4214811246 modified "2023-10-05" @default.
- W4214811246 title "Faculty Opinions recommendation of Identification of naturally occurring fatty acids of the myelin sheath that resolve neuroinflammation." @default.
- W4214811246 doi "https://doi.org/10.3410/f.717197851.792452854" @default.
- W4214811246 hasPublicationYear "2012" @default.
- W4214811246 type Work @default.
- W4214811246 citedByCount "0" @default.
- W4214811246 crossrefType "dataset" @default.
- W4214811246 hasAuthorship W4214811246A5005416364 @default.
- W4214811246 hasBestOaLocation W42148112461 @default.
- W4214811246 hasConcept C104317684 @default.
- W4214811246 hasConcept C150194340 @default.
- W4214811246 hasConcept C159654299 @default.
- W4214811246 hasConcept C163764329 @default.
- W4214811246 hasConcept C169760540 @default.
- W4214811246 hasConcept C185592680 @default.
- W4214811246 hasConcept C186836561 @default.
- W4214811246 hasConcept C203014093 @default.
- W4214811246 hasConcept C2776330855 @default.
- W4214811246 hasConcept C2776914184 @default.
- W4214811246 hasConcept C2778486448 @default.
- W4214811246 hasConcept C2778609137 @default.
- W4214811246 hasConcept C2778918659 @default.
- W4214811246 hasConcept C2779637612 @default.
- W4214811246 hasConcept C2780640218 @default.
- W4214811246 hasConcept C41625074 @default.
- W4214811246 hasConcept C529278444 @default.
- W4214811246 hasConcept C55493867 @default.
- W4214811246 hasConcept C58017582 @default.
- W4214811246 hasConcept C71924100 @default.
- W4214811246 hasConcept C86803240 @default.
- W4214811246 hasConcept C87753298 @default.
- W4214811246 hasConceptScore W4214811246C104317684 @default.
- W4214811246 hasConceptScore W4214811246C150194340 @default.
- W4214811246 hasConceptScore W4214811246C159654299 @default.
- W4214811246 hasConceptScore W4214811246C163764329 @default.
- W4214811246 hasConceptScore W4214811246C169760540 @default.
- W4214811246 hasConceptScore W4214811246C185592680 @default.
- W4214811246 hasConceptScore W4214811246C186836561 @default.
- W4214811246 hasConceptScore W4214811246C203014093 @default.
- W4214811246 hasConceptScore W4214811246C2776330855 @default.
- W4214811246 hasConceptScore W4214811246C2776914184 @default.
- W4214811246 hasConceptScore W4214811246C2778486448 @default.
- W4214811246 hasConceptScore W4214811246C2778609137 @default.
- W4214811246 hasConceptScore W4214811246C2778918659 @default.
- W4214811246 hasConceptScore W4214811246C2779637612 @default.
- W4214811246 hasConceptScore W4214811246C2780640218 @default.
- W4214811246 hasConceptScore W4214811246C41625074 @default.
- W4214811246 hasConceptScore W4214811246C529278444 @default.
- W4214811246 hasConceptScore W4214811246C55493867 @default.
- W4214811246 hasConceptScore W4214811246C58017582 @default.
- W4214811246 hasConceptScore W4214811246C71924100 @default.
- W4214811246 hasConceptScore W4214811246C86803240 @default.
- W4214811246 hasConceptScore W4214811246C87753298 @default.
- W4214811246 hasLocation W42148112461 @default.
- W4214811246 hasOpenAccess W4214811246 @default.
- W4214811246 hasPrimaryLocation W42148112461 @default.
- W4214811246 hasRelatedWork W1520073414 @default.
- W4214811246 hasRelatedWork W1587662096 @default.
- W4214811246 hasRelatedWork W1980929094 @default.
- W4214811246 hasRelatedWork W2048465125 @default.
- W4214811246 hasRelatedWork W2082730917 @default.
- W4214811246 hasRelatedWork W2250218381 @default.
- W4214811246 hasRelatedWork W2317954243 @default.
- W4214811246 hasRelatedWork W3111192594 @default.
- W4214811246 hasRelatedWork W4386188628 @default.
- W4214811246 hasRelatedWork W950194781 @default.
- W4214811246 isParatext "false" @default.
- W4214811246 isRetracted "false" @default.
- W4214811246 workType "dataset" @default.