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• W4214811474 abstract "Abstract Gaseous molecules have been increasingly explored for therapeutic development. Here, following an analytical background introduction, a systematic review of medical gas research is presented, focusing on tissue protections, mechanisms, data tangibility, and translational challenges. The pharmacological efficacies of carbon monoxide (CO) and xenon (Xe) are further examined with emphasis on intracellular messengers associated with cytoprotection and functional improvement for the CNS, heart, retina, liver, kidneys, lungs, etc. Overall, the outcome supports the hypothesis that readily deliverable “biological gas” (CO, H 2 , H 2 S, NO, O 2 , O 3 , and N 2 O) or “noble gas” (He, Ar, and Xe) treatment may preserve cells against common pathologies by regulating oxidative, inflammatory, apoptotic, survival, and/or repair processes. Specifically, CO, in safe dosages, elicits neurorestoration via igniting sGC/cGMP/MAPK signaling and crosstalk between HO‐CO, HIF‐1 α /VEGF, and NOS pathways. Xe rescues neurons through NMDA antagonism and PI3K/Akt/HIF‐1 α /ERK activation. Primary findings also reveal that the need to utilize cutting‐edge molecular and genetic tactics to validate mechanistic targets and optimize outcome consistency remains urgent; the number of neurotherapeutic investigations is limited, without published results from large in vivo models. Lastly, the broad‐spectrum, concurrent multimodal homeostatic actions of medical gases may represent a novel pharmaceutical approach to treating critical organ failure and neurotrauma." @default.
• W4214811474 created "2022-03-05" @default.
• W4214811474 creator A5015090281 @default.
• W4214811474 creator A5038804811 @default.
• W4214811474 creator A5077605804 @default.
• W4214811474 creator A5083475763 @default.
• W4214811474 creator A5090535008 @default.
• W4214811474 date "2022-03-04" @default.
• W4214811474 modified "2023-10-15" @default.
• W4214811474 title "Medical Gas Therapy for Tissue, Organ, and CNS Protection: A Systematic Review of Effects, Mechanisms, and Challenges" @default.
• W4214811474 cites W1044743974 @default.
• W4214811474 cites W146073362 @default.
• W4214811474 cites W1488628523 @default.
• W4214811474 cites W1491748969 @default.
• W4214811474 cites W1513688502 @default.
• W4214811474 cites W1522191426 @default.
• W4214811474 cites W1600618224 @default.
• W4214811474 cites W1633272553 @default.
• W4214811474 cites W1660684267 @default.
• W4214811474 cites W166790841 @default.
• W4214811474 cites W1677674744 @default.
• W4214811474 cites W1694753412 @default.
• W4214811474 cites W1729182783 @default.
• W4214811474 cites W1764016564 @default.
• W4214811474 cites W1812961065 @default.
• W4214811474 cites W1879029122 @default.
• W4214811474 cites W1927797304 @default.
• W4214811474 cites W1929009802 @default.
• W4214811474 cites W1960828910 @default.
• W4214811474 cites W1973272135 @default.
• W4214811474 cites W1973952682 @default.
• W4214811474 cites W1974361621 @default.
• W4214811474 cites W1975310796 @default.
• W4214811474 cites W1976398459 @default.
• W4214811474 cites W1977281486 @default.
• W4214811474 cites W1977909771 @default.
• W4214811474 cites W1978644822 @default.
• W4214811474 cites W1980812782 @default.
• W4214811474 cites W1981413499 @default.
• W4214811474 cites W1981822342 @default.
• W4214811474 cites W1984309244 @default.
• W4214811474 cites W1984347108 @default.
• W4214811474 cites W1985048387 @default.
• W4214811474 cites W1985140057 @default.
• W4214811474 cites W1987662138 @default.
• W4214811474 cites W1989721436 @default.
• W4214811474 cites W1989805864 @default.
• W4214811474 cites W1990464150 @default.
• W4214811474 cites W1993732825 @default.
• W4214811474 cites W1995613991 @default.
• W4214811474 cites W1995681173 @default.
• W4214811474 cites W1996828515 @default.
• W4214811474 cites W2000063865 @default.
• W4214811474 cites W2000917831 @default.
• W4214811474 cites W2001277810 @default.
• W4214811474 cites W2003880271 @default.
• W4214811474 cites W2005539486 @default.
• W4214811474 cites W2005614700 @default.
• W4214811474 cites W2005858206 @default.
• W4214811474 cites W2012399033 @default.
• W4214811474 cites W2014049944 @default.
• W4214811474 cites W2014114611 @default.
• W4214811474 cites W2014218547 @default.
• W4214811474 cites W2014789843 @default.
• W4214811474 cites W2017715658 @default.
• W4214811474 cites W2018695645 @default.
• W4214811474 cites W2020866868 @default.
• W4214811474 cites W2020941408 @default.
• W4214811474 cites W2022941394 @default.
• W4214811474 cites W2023881029 @default.
• W4214811474 cites W2027375453 @default.
• W4214811474 cites W2027893779 @default.
• W4214811474 cites W2028778467 @default.
• W4214811474 cites W2029850339 @default.
• W4214811474 cites W2031915872 @default.
• W4214811474 cites W2032760775 @default.
• W4214811474 cites W2033197778 @default.
• W4214811474 cites W2033691305 @default.
• W4214811474 cites W2038182595 @default.
• W4214811474 cites W2041745928 @default.
• W4214811474 cites W2042761370 @default.
• W4214811474 cites W2043094723 @default.
• W4214811474 cites W2046477467 @default.
• W4214811474 cites W2047474537 @default.
• W4214811474 cites W2048798186 @default.
• W4214811474 cites W2049187970 @default.
• W4214811474 cites W2049800847 @default.
• W4214811474 cites W2049842515 @default.
• W4214811474 cites W2049957139 @default.
• W4214811474 cites W2051876980 @default.
• W4214811474 cites W2054263057 @default.
• W4214811474 cites W2055207233 @default.
• W4214811474 cites W2055611204 @default.
• W4214811474 cites W2055747781 @default.
• W4214811474 cites W2060460101 @default.
• W4214811474 cites W2063915148 @default.
• W4214811474 cites W2065289753 @default.
• W4214811474 cites W2068000172 @default.
• W4214811474 cites W2070202199 @default.
• W4214811474 cites W2070280707 @default.

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