Matches in SemOpenAlex for { <https://semopenalex.org/work/W4214817725> ?p ?o ?g. }
- W4214817725 endingPage "858" @default.
- W4214817725 startingPage "858" @default.
- W4214817725 abstract "Chronological aging is defined as a time-dependent decline of tissue homeostasis which severely impacts skin. Understanding the mechanisms of skin aging is an active research area limited by the lack of relevant in vitro models. Being a component of aging, replicative or stress-induced senescence is repeatedly used to mimic skin aging in vitro, thus presenting only a partial view of the complexity of aging. Herein, we aimed to clarify whether primary normal human dermal fibroblasts retained age-related characteristics when cultured in 2D monolayer, and could be used as a relevant model for aging research. We compared three groups of fibroblasts isolated from different aged donors. We observed strongly decreased population doubling capacities, a reduced clonogenic ability, an impairment in extracellular matrix production together with modifications of respiratory metabolism with an increase in age. These disruptions were particularly marked when comparing fibroblasts isolated from old individuals (over 70 years old) to those isolated from young individuals (18-37 years old), while cells from middle-aged donors exhibited an intermediate profile. These alterations of cell features can be related to the signs of dermis aging, thus showing that cultured primary cells indeed retain some characteristics of the original tissue from which they were extracted." @default.
- W4214817725 created "2022-03-05" @default.
- W4214817725 creator A5009355071 @default.
- W4214817725 creator A5020062703 @default.
- W4214817725 creator A5023237364 @default.
- W4214817725 creator A5030879415 @default.
- W4214817725 creator A5032830495 @default.
- W4214817725 creator A5048405718 @default.
- W4214817725 creator A5065290880 @default.
- W4214817725 creator A5089453868 @default.
- W4214817725 date "2022-03-02" @default.
- W4214817725 modified "2023-10-17" @default.
- W4214817725 title "Maintenance of Chronological Aging Features in Culture of Normal Human Dermal Fibroblasts from Old Donors" @default.
- W4214817725 cites W1593918796 @default.
- W4214817725 cites W1631191622 @default.
- W4214817725 cites W1899095474 @default.
- W4214817725 cites W1904404779 @default.
- W4214817725 cites W1970266671 @default.
- W4214817725 cites W1972250033 @default.
- W4214817725 cites W1992687364 @default.
- W4214817725 cites W1998663807 @default.
- W4214817725 cites W2010345740 @default.
- W4214817725 cites W2021407576 @default.
- W4214817725 cites W2021703205 @default.
- W4214817725 cites W2034311985 @default.
- W4214817725 cites W2037734479 @default.
- W4214817725 cites W2039773944 @default.
- W4214817725 cites W2051146905 @default.
- W4214817725 cites W2052101576 @default.
- W4214817725 cites W2063087581 @default.
- W4214817725 cites W2065502996 @default.
- W4214817725 cites W2071419221 @default.
- W4214817725 cites W2081747986 @default.
- W4214817725 cites W2102867223 @default.
- W4214817725 cites W2106774689 @default.
- W4214817725 cites W2114951137 @default.
- W4214817725 cites W2123032632 @default.
- W4214817725 cites W2126525177 @default.
- W4214817725 cites W2129671660 @default.
- W4214817725 cites W2137874618 @default.
- W4214817725 cites W2150748567 @default.
- W4214817725 cites W2510899048 @default.
- W4214817725 cites W2531587677 @default.
- W4214817725 cites W2573540928 @default.
- W4214817725 cites W2788548733 @default.
- W4214817725 cites W2793032798 @default.
- W4214817725 cites W2803490690 @default.
- W4214817725 cites W2912918280 @default.
- W4214817725 cites W2925154616 @default.
- W4214817725 cites W2940564657 @default.
- W4214817725 cites W2954987929 @default.
- W4214817725 cites W2990644998 @default.
- W4214817725 cites W3017377629 @default.
- W4214817725 cites W3089994865 @default.
- W4214817725 cites W3111545648 @default.
- W4214817725 doi "https://doi.org/10.3390/cells11050858" @default.
- W4214817725 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35269480" @default.
- W4214817725 hasPublicationYear "2022" @default.
- W4214817725 type Work @default.
- W4214817725 citedByCount "7" @default.
- W4214817725 countsByYear W42148177252022 @default.
- W4214817725 countsByYear W42148177252023 @default.
- W4214817725 crossrefType "journal-article" @default.
- W4214817725 hasAuthorship W4214817725A5009355071 @default.
- W4214817725 hasAuthorship W4214817725A5020062703 @default.
- W4214817725 hasAuthorship W4214817725A5023237364 @default.
- W4214817725 hasAuthorship W4214817725A5030879415 @default.
- W4214817725 hasAuthorship W4214817725A5032830495 @default.
- W4214817725 hasAuthorship W4214817725A5048405718 @default.
- W4214817725 hasAuthorship W4214817725A5065290880 @default.
- W4214817725 hasAuthorship W4214817725A5089453868 @default.
- W4214817725 hasBestOaLocation W42148177251 @default.
- W4214817725 hasConcept C105702510 @default.
- W4214817725 hasConcept C117262875 @default.
- W4214817725 hasConcept C142724271 @default.
- W4214817725 hasConcept C16005928 @default.
- W4214817725 hasConcept C177336024 @default.
- W4214817725 hasConcept C189165786 @default.
- W4214817725 hasConcept C202751555 @default.
- W4214817725 hasConcept C2777624698 @default.
- W4214817725 hasConcept C2780381497 @default.
- W4214817725 hasConcept C2908647359 @default.
- W4214817725 hasConcept C2908780919 @default.
- W4214817725 hasConcept C2909910311 @default.
- W4214817725 hasConcept C522857546 @default.
- W4214817725 hasConcept C54355233 @default.
- W4214817725 hasConcept C552990157 @default.
- W4214817725 hasConcept C71924100 @default.
- W4214817725 hasConcept C86803240 @default.
- W4214817725 hasConcept C95444343 @default.
- W4214817725 hasConcept C99454951 @default.
- W4214817725 hasConceptScore W4214817725C105702510 @default.
- W4214817725 hasConceptScore W4214817725C117262875 @default.
- W4214817725 hasConceptScore W4214817725C142724271 @default.
- W4214817725 hasConceptScore W4214817725C16005928 @default.
- W4214817725 hasConceptScore W4214817725C177336024 @default.
- W4214817725 hasConceptScore W4214817725C189165786 @default.
- W4214817725 hasConceptScore W4214817725C202751555 @default.