FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4214824416> ?p ?o ?g. }

• W4214824416 endingPage "154012" @default.
• W4214824416 startingPage "154012" @default.
• W4214824416 abstract "Plant triterpenoids are major sources of nutraceuticals that provide many health benefits to humans. Lupeol is one of the pentacyclic dietary triterpenoids commonly found in many fruits and vegetables, which is highly investigated for its pharmacological effect and benefit to human health.This systematic review critically discussed the potential pharmacological benefits of lupeol and its derivatives as evidenced by various cellular and animal model studies. To gain insight into the pharmacological effects of lupeol, the network pharmacological approach is applied. Pharmacokinetics and recent developments in nanotechnology-based approaches to targeted delivery of lupeol along with its safety use are also discussed.This study is dependent on the systematic and non-exhaustive literature survey for related research articles, papers, and books on the chemistry, pharmacological benefits, pharmacokinetics, and safety of lupeol published between 2011 and 2021. For online materials, the popular academic search engines viz. Google Scholar, PubMed, Science Direct, Scopus, ResearchGate, Springer, as well as official websites were explored with selected keywords.Lupeol has shown promising benefits in the management of cancer and many other human diseases such as diabetes, obesity, cardiovascular diseases, kidney and liver problems, skin diseases, and neurological disorders. The pharmacological effects of lupeol primarily rely on its capacity to revitalize the cellular antioxidant, anti-inflammatory and anti-apoptotic mechanisms. Network pharmacological approach revealed some prospective molecular targets and pathways and presented some significant information that could help explain the pharmacological effects of lupeol and its derivatives. Despite significant progress in molecular pharmacology, the clinical application of lupeol is limited due to poor bioavailability and insufficient knowledge on its mode of action. Structural modification and nanotechnology-guided targeted delivery of lupeol improve the bioavailability and bioactivity of lupeol.The pentacyclic triterpene lupeol possesses numerous human health-benefiting properties. This review updates current knowledge and critically discusses the pharmacological effects and potential applications of lupeol and its derivatives in human health and diseases. Future studies are needed to evaluate the efficacies of lupeol and its derivatives in the management and pathobiology of human diseases." @default.
• W4214824416 created "2022-03-05" @default.
• W4214824416 creator A5003513047 @default.
• W4214824416 creator A5012594298 @default.
• W4214824416 creator A5027179277 @default.
• W4214824416 creator A5035196538 @default.
• W4214824416 creator A5037386652 @default.
• W4214824416 creator A5043160253 @default.
• W4214824416 creator A5048566776 @default.
• W4214824416 creator A5055340556 @default.
• W4214824416 creator A5063951087 @default.
• W4214824416 creator A5067406841 @default.
• W4214824416 creator A5068957917 @default.
• W4214824416 creator A5069819330 @default.
• W4214824416 creator A5072197791 @default.
• W4214824416 creator A5077717775 @default.
• W4214824416 creator A5085500023 @default.
• W4214824416 date "2022-05-01" @default.
• W4214824416 modified "2023-10-15" @default.
• W4214824416 title "Molecular pharmacology and therapeutic advances of the pentacyclic triterpene lupeol" @default.
• W4214824416 cites W1465495262 @default.
• W4214824416 cites W1810319096 @default.
• W4214824416 cites W1876269047 @default.
• W4214824416 cites W1954057958 @default.
• W4214824416 cites W1968161181 @default.
• W4214824416 cites W1980250100 @default.
• W4214824416 cites W1980481733 @default.
• W4214824416 cites W1981937975 @default.
• W4214824416 cites W1982415074 @default.
• W4214824416 cites W1986482685 @default.
• W4214824416 cites W1994862158 @default.
• W4214824416 cites W1995034379 @default.
• W4214824416 cites W1996023050 @default.
• W4214824416 cites W2000482000 @default.
• W4214824416 cites W2003537732 @default.
• W4214824416 cites W2005262157 @default.
• W4214824416 cites W2006013671 @default.
• W4214824416 cites W2006754373 @default.
• W4214824416 cites W2007227092 @default.
• W4214824416 cites W2013567877 @default.
• W4214824416 cites W2015502247 @default.
• W4214824416 cites W2018271393 @default.
• W4214824416 cites W2019728633 @default.
• W4214824416 cites W2022379734 @default.
• W4214824416 cites W2026327276 @default.
• W4214824416 cites W2027752180 @default.
• W4214824416 cites W2031130179 @default.
• W4214824416 cites W2031809651 @default.
• W4214824416 cites W2042180286 @default.
• W4214824416 cites W2048721788 @default.
• W4214824416 cites W2058233843 @default.
• W4214824416 cites W2059621414 @default.
• W4214824416 cites W2066390677 @default.
• W4214824416 cites W2073397664 @default.
• W4214824416 cites W2073803388 @default.
• W4214824416 cites W2079618076 @default.
• W4214824416 cites W2079979102 @default.
• W4214824416 cites W2080447135 @default.
• W4214824416 cites W2088836460 @default.
• W4214824416 cites W2092905413 @default.
• W4214824416 cites W2094722121 @default.
• W4214824416 cites W2099239115 @default.
• W4214824416 cites W2111016526 @default.
• W4214824416 cites W2111023674 @default.
• W4214824416 cites W2124085922 @default.
• W4214824416 cites W2124679671 @default.
• W4214824416 cites W2133630830 @default.
• W4214824416 cites W2135334331 @default.
• W4214824416 cites W2150811885 @default.
• W4214824416 cites W2163166380 @default.
• W4214824416 cites W2170869159 @default.
• W4214824416 cites W2284606198 @default.
• W4214824416 cites W2301790538 @default.
• W4214824416 cites W2337050167 @default.
• W4214824416 cites W2400274111 @default.
• W4214824416 cites W2566191205 @default.
• W4214824416 cites W2614634628 @default.
• W4214824416 cites W2620007374 @default.
• W4214824416 cites W2729335986 @default.
• W4214824416 cites W2729776863 @default.
• W4214824416 cites W2735527928 @default.
• W4214824416 cites W2736943476 @default.
• W4214824416 cites W2761836199 @default.
• W4214824416 cites W2786256302 @default.
• W4214824416 cites W2790298674 @default.
• W4214824416 cites W2792306782 @default.
• W4214824416 cites W2898577195 @default.
• W4214824416 cites W2899421833 @default.
• W4214824416 cites W2901107708 @default.
• W4214824416 cites W2902487177 @default.
• W4214824416 cites W2909426596 @default.
• W4214824416 cites W2912516733 @default.
• W4214824416 cites W2921188258 @default.
• W4214824416 cites W2928666462 @default.
• W4214824416 cites W2930242822 @default.
• W4214824416 cites W2934715256 @default.
• W4214824416 cites W2935024989 @default.
• W4214824416 cites W2939874894 @default.

• next